ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 77/766 152/7206 6.06539719794e-36 ko05033 Nicotine addiction 45/766 56/7206 2.28391624645e-34 ko04080 Neuroactive ligand-receptor interaction 126/766 423/7206 1.68858947185e-29 ko05032 Morphine addiction 57/766 110/7206 1.88844671762e-27 ko04727 GABAergic synapse 54/766 110/7206 1.46387558824e-24 ko04723 Retrograde endocannabinoid signaling 64/766 175/7206 2.55503366396e-20 ko04713 Circadian entrainment 55/766 136/7206 5.66501554878e-20 ko04728 Dopaminergic synapse 64/766 185/7206 7.27522431587e-19 ko04024 cAMP signaling pathway 81/766 279/7206 2.94631062422e-18 ko05030 Cocaine addiction 35/766 73/7206 6.54312965823e-16 ko04725 Cholinergic synapse 52/766 160/7206 2.99734000735e-14 ko04911 Insulin secretion 40/766 117/7206 4.95395461078e-12 ko04261 Adrenergic signaling in cardiomyocytes 56/766 205/7206 9.8407722376e-12 ko04921 Oxytocin signaling pathway 55/766 209/7206 1.17881612813e-10 ko04721 Synaptic vesicle cycle 30/766 80/7206 1.77906361775e-10 ko05031 Amphetamine addiction 32/766 91/7206 3.04650463733e-10 ko04726 Serotonergic synapse 41/766 137/7206 3.11829840244e-10 ko04020 Calcium signaling pathway 63/766 265/7206 3.47941459532e-10 ko04720 Long-term potentiation 32/766 99/7206 3.46478020097e-09 ko04360 Axon guidance 55/766 233/7206 6.96879417349e-09 ko04010 MAPK signaling pathway 68/766 321/7206 1.4268420196e-08 ko04072 Phospholipase D signaling pathway 47/766 197/7206 5.86172504027e-08 ko04970 Salivary secretion 29/766 95/7206 7.88925901967e-08 ko04742 Taste transduction 21/766 61/7206 5.3629352257e-07 ko04514 Cell adhesion molecules (CAMs) 33/766 130/7206 1.62027090868e-06 ko04915 Estrogen signaling pathway 33/766 131/7206 1.82839761955e-06 ko03040 Spliceosome 1/766 145/7206 2.0321567688e-06 ko04972 Pancreatic secretion 29/766 111/7206 2.90575665754e-06 ko04022 cGMP-PKG signaling pathway 45/766 216/7206 8.29403143554e-06 ko04925 Aldosterone synthesis and secretion 27/766 105/7206 8.78511916955e-06 ko04730 Long-term depression 22/766 78/7206 1.22547047438e-05 ko05414 Dilated cardiomyopathy 28/766 112/7206 1.38153646528e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/766 79/7206 1.53153433808e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 21/766 74/7206 1.73830486378e-05 ko03013 RNA transport 3/766 166/7206 1.79171699171e-05 ko05203 Viral carcinogenesis 10/766 277/7206 2.35548486242e-05 ko04540 Gap junction 30/766 128/7206 2.87964772902e-05 ko04971 Gastric acid secretion 24/766 98/7206 8.007636838e-05 ko04961 Endocrine and other factor-regulated calcium reabsorption 17/766 59/7206 8.83615043251e-05 ko04015 Rap1 signaling pathway 49/766 278/7206 0.00031479451755 ko05322 Systemic lupus erythematosus 4/766 151/7206 0.00041932863159 ko04923 Regulation of lipolysis in adipocytes 19/766 77/7206 0.000497187670579 ko04260 Cardiac muscle contraction 22/766 98/7206 0.000683762023337 ko04060 Cytokine-cytokine receptor interaction 7/766 191/7206 0.000739758426707 ko04141 Protein processing in endoplasmic reticulum 7/766 184/7206 0.000982778751123 ko05168 Herpes simplex infection 7/766 182/7206 0.00136297449117 ko04217 Necroptosis 7/766 178/7206 0.0018600169832 ko03018 RNA degradation 1/766 84/7206 0.00188629378946 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/766 14/7206 0.00200498485058 ko04014 Ras signaling pathway 46/766 279/7206 0.00205977006561 ko04918 Thyroid hormone synthesis 19/766 86/7206 0.00209725436082 ko04110 Cell cycle 5/766 145/7206 0.00245350166298 ko05231 Choline metabolism in cancer 26/766 134/7206 0.00253240955964 ko04666 Fc gamma R-mediated phagocytosis 24/766 122/7206 0.00263896134182 ko03008 Ribosome biogenesis in eukaryotes 1/766 79/7206 0.00268392893606 ko00190 Oxidative phosphorylation 4/766 127/7206 0.00324609607388 ko01200 Carbon metabolism 4/766 128/7206 0.0033094028644 ko04744 Phototransduction 10/766 36/7206 0.00336593966928 ko05205 Proteoglycans in cancer 15/766 271/7206 0.00463005680093 ko04070 Phosphatidylinositol signaling system 22/766 112/7206 0.00464930623551 ko05410 Hypertrophic cardiomyopathy (HCM) 20/766 100/7206 0.00479694130766 ko04976 Bile secretion 17/766 80/7206 0.00507425186925 ko04930 Type II diabetes mellitus 13/766 54/7206 0.00580223424088 ko04371 Apelin signaling pathway 30/766 177/7206 0.00905202221282 ko04914 Progesterone-mediated oocyte maturation 20/766 104/7206 0.00913288834074 ko05034 Alcoholism 38/766 238/7206 0.00987621717097 ko04932 Non-alcoholic fatty liver disease (NAFLD) 9/766 182/7206 0.00993978925607 ko05164 Influenza A 8/766 167/7206 0.0105429215166 ko05169 Epstein-Barr virus infection 11/766 206/7206 0.0110694802577 ko04640 Hematopoietic cell lineage 1/766 64/7206 0.0126603846547 ko00515 Mannose type O-glycan biosynthesis 7/766 25/7206 0.0129264152528 ko04612 Antigen processing and presentation 2/766 77/7206 0.0149370629645 ko04142 Lysosome 7/766 151/7206 0.0152992439396 ko04270 Vascular smooth muscle contraction 26/766 154/7206 0.0165052625375 ko04621 NOD-like receptor signaling pathway 8/766 157/7206 0.018343565969 ko04916 Melanogenesis 24/766 142/7206 0.0190060878523 ko04144 Endocytosis 50/766 342/7206 0.0190089526815 ko04071 Sphingolipid signaling pathway 27/766 162/7206 0.019233015567 ko00010 Glycolysis / Gluconeogenesis 2/766 74/7206 0.0214092361074 ko04213 Longevity regulating pathway - multiple species 16/766 86/7206 0.0216204064181 ko04146 Peroxisome 3/766 89/7206 0.022830907667 ko04350 TGF-beta signaling pathway 4/766 103/7206 0.0228421579092 ko04750 Inflammatory mediator regulation of TRP channels 21/766 122/7206 0.0249761987977 ko04740 Olfactory transduction 15/766 80/7206 0.0266134992515 ko05321 Inflammatory bowel disease (IBD) 1/766 56/7206 0.0269700129522 ko01230 Biosynthesis of amino acids 3/766 85/7206 0.0317221230614 ko04120 Ubiquitin mediated proteolysis 7/766 138/7206 0.0349740370453 ko04064 NF-kappa B signaling pathway 4/766 96/7206 0.0431147115456 ko04138 Autophagy - yeast 3/766 81/7206 0.0439041885643 ko04137 Mitophagy - animal 3/766 82/7206 0.0446274000966