ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 134/672 423/7206 3.66786150458e-41 ko04724 Glutamatergic synapse 69/672 152/7206 4.13879488672e-32 ko05033 Nicotine addiction 41/672 56/7206 7.76716437259e-31 ko04727 GABAergic synapse 47/672 110/7206 9.1922240799e-21 ko05032 Morphine addiction 46/672 110/7206 7.01758731062e-20 ko04728 Dopaminergic synapse 60/672 185/7206 5.21439450269e-19 ko04723 Retrograde endocannabinoid signaling 57/672 175/7206 3.33117195909e-18 ko04713 Circadian entrainment 49/672 136/7206 7.55255625619e-18 ko04024 cAMP signaling pathway 69/672 279/7206 9.26651904727e-15 ko04020 Calcium signaling pathway 66/672 265/7206 2.57579127035e-14 ko04911 Insulin secretion 40/672 117/7206 6.72405726361e-14 ko04725 Cholinergic synapse 47/672 160/7206 2.6829851775e-13 ko05031 Amphetamine addiction 32/672 91/7206 9.58524080819e-12 ko05030 Cocaine addiction 28/672 73/7206 1.75062870485e-11 ko04742 Taste transduction 25/672 61/7206 3.90604197528e-11 ko04726 Serotonergic synapse 39/672 137/7206 8.79877967027e-11 ko04261 Adrenergic signaling in cardiomyocytes 50/672 205/7206 9.46948256683e-11 ko04720 Long-term potentiation 32/672 99/7206 1.21823681088e-10 ko04010 MAPK signaling pathway 66/672 321/7206 3.6237930005e-10 ko04921 Oxytocin signaling pathway 47/672 209/7206 7.14803908925e-09 ko04721 Synaptic vesicle cycle 25/672 80/7206 2.89215003551e-08 ko04060 Cytokine-cytokine receptor interaction 1/672 191/7206 2.03933714015e-07 ko04925 Aldosterone synthesis and secretion 27/672 105/7206 7.03304065676e-07 ko04970 Salivary secretion 24/672 95/7206 4.08792735647e-06 ko04072 Phospholipase D signaling pathway 39/672 197/7206 4.63558487204e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 20/672 74/7206 8.68190528299e-06 ko04514 Cell adhesion molecules (CAMs) 29/672 130/7206 8.86879094024e-06 ko04972 Pancreatic secretion 25/672 111/7206 2.27358930095e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/672 79/7206 2.49696189845e-05 ko04730 Long-term depression 19/672 78/7206 7.03250502576e-05 ko04915 Estrogen signaling pathway 27/672 131/7206 9.30224768591e-05 ko05414 Dilated cardiomyopathy 24/672 112/7206 9.3368723267e-05 ko04022 cGMP-PKG signaling pathway 38/672 216/7206 0.000112189396234 ko04260 Cardiac muscle contraction 21/672 98/7206 0.000278156585177 ko05203 Viral carcinogenesis 10/672 277/7206 0.000304520982594 ko04360 Axon guidance 39/672 233/7206 0.000318400454303 ko04971 Gastric acid secretion 20/672 98/7206 0.000653924402779 ko05168 Herpes simplex infection 5/672 182/7206 0.00069392120993 ko04110 Cell cycle 3/672 145/7206 0.000758814720883 ko04930 Type II diabetes mellitus 13/672 54/7206 0.00108492527256 ko04070 Phosphatidylinositol signaling system 21/672 112/7206 0.00158458282088 ko05322 Systemic lupus erythematosus 4/672 151/7206 0.00254982809234 ko00240 Pyrimidine metabolism 2/672 110/7206 0.00259475632348 ko00190 Oxidative phosphorylation 3/672 127/7206 0.00308572063828 ko05410 Hypertrophic cardiomyopathy (HCM) 18/672 100/7206 0.0052651516676 ko04350 TGF-beta signaling pathway 2/672 103/7206 0.00546017271294 ko03008 Ribosome biogenesis in eukaryotes 1/672 79/7206 0.00606660504928 ko05034 Alcoholism 35/672 238/7206 0.00617470363003 ko04320 Dorso-ventral axis formation 8/672 31/7206 0.00622717615663 ko00515 Mannose type O-glycan biosynthesis 7/672 25/7206 0.00640546939618 ko04932 Non-alcoholic fatty liver disease (NAFLD) 7/672 182/7206 0.00647334152157 ko03013 RNA transport 6/672 166/7206 0.00665308801528 ko04142 Lysosome 5/672 151/7206 0.00671775785387 ko04540 Gap junction 21/672 128/7206 0.00878680231202 ko04630 Jak-STAT signaling pathway 4/672 132/7206 0.00927305474043 ko04740 Olfactory transduction 15/672 80/7206 0.00993087109266 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/672 59/7206 0.0103274312156 ko04621 NOD-like receptor signaling pathway 6/672 157/7206 0.0121195193301 ko05205 Proteoglycans in cancer 14/672 271/7206 0.013983575994 ko00512 Mucin type O-glycan biosynthesis 7/672 29/7206 0.0149986288425 ko04146 Peroxisome 2/672 89/7206 0.0157126530089 ko05231 Choline metabolism in cancer 21/672 134/7206 0.0157493843207 ko03320 PPAR signaling pathway 1/672 69/7206 0.0195231357321 ko05164 Influenza A 7/672 167/7206 0.0209074028045 ko03018 RNA degradation 2/672 84/7206 0.0222006719092 ko00562 Inositol phosphate metabolism 15/672 89/7206 0.0250253729951 ko04940 Type I diabetes mellitus 7/672 32/7206 0.0253540472625 ko04923 Regulation of lipolysis in adipocytes 13/672 77/7206 0.029285664826 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/672 14/7206 0.0351615978072 ko00430 Taurine and hypotaurine metabolism 4/672 14/7206 0.0351615978072 ko04918 Thyroid hormone synthesis 14/672 86/7206 0.0373773041579 ko04120 Ubiquitin mediated proteolysis 6/672 138/7206 0.0383969955014 ko04141 Protein processing in endoplasmic reticulum 9/672 184/7206 0.0386496043743 ko04071 Sphingolipid signaling pathway 23/672 162/7206 0.0392561016625 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 6/672 28/7206 0.0409517219072 ko01212 Fatty acid metabolism 1/672 60/7206 0.041103093144 ko00330 Arginine and proline metabolism 1/672 61/7206 0.0420776446425 ko02024 Quorum sensing 4/672 15/7206 0.0445140492349 ko04015 Rap1 signaling pathway 36/672 278/7206 0.0446898107978 ko04670 Leukocyte transendothelial migration 7/672 151/7206 0.0465547352856