ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 195/1154 423/7206 1.280040082e-51 ko04724 Glutamatergic synapse 87/1154 152/7206 8.06666714427e-32 ko05033 Nicotine addiction 48/1154 56/7206 1.08724843237e-30 ko05032 Morphine addiction 66/1154 110/7206 5.37068763459e-26 ko04713 Circadian entrainment 74/1154 136/7206 2.70377955235e-25 ko04727 GABAergic synapse 63/1154 110/7206 2.57878778836e-23 ko04721 Synaptic vesicle cycle 50/1154 80/7206 4.37586362886e-21 ko04728 Dopaminergic synapse 82/1154 185/7206 2.45310914687e-20 ko04725 Cholinergic synapse 73/1154 160/7206 4.2647228138e-19 ko04723 Retrograde endocannabinoid signaling 76/1154 175/7206 2.73604600668e-18 ko04024 cAMP signaling pathway 101/1154 279/7206 4.74538240883e-17 ko04020 Calcium signaling pathway 97/1154 265/7206 7.95577288097e-17 ko04726 Serotonergic synapse 62/1154 137/7206 3.53677753315e-16 ko04744 Phototransduction 26/1154 36/7206 8.07015643336e-14 ko04742 Taste transduction 35/1154 61/7206 1.5696574489e-13 ko04911 Insulin secretion 51/1154 117/7206 9.63642183438e-13 ko04921 Oxytocin signaling pathway 75/1154 209/7206 9.99045419255e-13 ko05031 Amphetamine addiction 41/1154 91/7206 4.70919301511e-11 ko04720 Long-term potentiation 42/1154 99/7206 2.85300981469e-10 ko04970 Salivary secretion 39/1154 95/7206 3.89253392718e-09 ko04261 Adrenergic signaling in cardiomyocytes 66/1154 205/7206 5.42796077184e-09 ko03040 Spliceosome 2/1154 145/7206 6.51546821723e-09 ko03010 Ribosome 1/1154 129/7206 6.72612799942e-09 ko05203 Viral carcinogenesis 14/1154 277/7206 2.09606363935e-08 ko05030 Cocaine addiction 30/1154 73/7206 2.38895800233e-07 ko04740 Olfactory transduction 31/1154 80/7206 7.15652633867e-07 ko04925 Aldosterone synthesis and secretion 37/1154 105/7206 1.20153869459e-06 ko04060 Cytokine-cytokine receptor interaction 9/1154 191/7206 1.77174896583e-06 ko03013 RNA transport 7/1154 166/7206 2.80263127794e-06 ko04360 Axon guidance 65/1154 233/7206 2.81799523722e-06 ko04971 Gastric acid secretion 34/1154 98/7206 4.72821349765e-06 ko05322 Systemic lupus erythematosus 6/1154 151/7206 4.94020105144e-06 ko05168 Herpes simplex infection 9/1154 182/7206 4.96480217708e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 28/1154 74/7206 6.54977266633e-06 ko04022 cGMP-PKG signaling pathway 60/1154 216/7206 7.7906154174e-06 ko04514 Cell adhesion molecules (CAMs) 41/1154 130/7206 8.98012836572e-06 ko05164 Influenza A 8/1154 167/7206 9.1261334674e-06 ko04070 Phosphatidylinositol signaling system 36/1154 112/7206 2.067983428e-05 ko04621 NOD-like receptor signaling pathway 8/1154 157/7206 3.65831281233e-05 ko04010 MAPK signaling pathway 79/1154 321/7206 4.64148100555e-05 ko04110 Cell cycle 7/1154 145/7206 4.81099018448e-05 ko04966 Collecting duct acid secretion 13/1154 26/7206 5.70392233651e-05 ko04730 Long-term depression 27/1154 78/7206 5.94113653282e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 27/1154 79/7206 6.86802960599e-05 ko04540 Gap junction 38/1154 128/7206 8.06030720272e-05 ko05169 Epstein-Barr virus infection 14/1154 206/7206 9.8317451209e-05 ko04745 Phototransduction - fly 16/1154 38/7206 0.000112159845618 ko04120 Ubiquitin mediated proteolysis 7/1154 138/7206 0.000139432025713 ko03008 Ribosome biogenesis in eukaryotes 2/1154 79/7206 0.000272799571917 ko04924 Renin secretion 27/1154 86/7206 0.000311985274034 ko04141 Protein processing in endoplasmic reticulum 13/1154 184/7206 0.000336726274693 ko05166 HTLV-I infection 26/1154 292/7206 0.000429283106144 ko05161 Hepatitis B 12/1154 173/7206 0.000477633978983 ko04972 Pancreatic secretion 32/1154 111/7206 0.000584416269828 ko04710 Circadian rhythm 16/1154 43/7206 0.000604917171563 ko05414 Dilated cardiomyopathy 32/1154 112/7206 0.000648535103648 ko04260 Cardiac muscle contraction 29/1154 98/7206 0.000705741597944 ko05110 Vibrio cholerae infection 21/1154 63/7206 0.00072799407778 ko04014 Ras signaling pathway 66/1154 279/7206 0.000808488182621 ko04626 Plant-pathogen interaction 9/1154 18/7206 0.00082478982126 ko05162 Measles 7/1154 120/7206 0.000996096399406 ko04610 Complement and coagulation cascades 3/1154 79/7206 0.00105496504581 ko04072 Phospholipase D signaling pathway 49/1154 197/7206 0.00108501590961 ko05205 Proteoglycans in cancer 25/1154 271/7206 0.00127470645787 ko04750 Inflammatory mediator regulation of TRP channels 33/1154 122/7206 0.00167431236042 ko04064 NF-kappa B signaling pathway 5/1154 96/7206 0.00184312986723 ko04961 Endocrine and other factor-regulated calcium reabsorption 19/1154 59/7206 0.00190456483551 ko05140 Leishmaniasis 3/1154 75/7206 0.0022339235024 ko04923 Regulation of lipolysis in adipocytes 23/1154 77/7206 0.00247307572816 ko04630 Jak-STAT signaling pathway 9/1154 132/7206 0.00249366390576 ko04330 Notch signaling pathway 2/1154 62/7206 0.00269399693431 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/1154 14/7206 0.00321989198343 ko04915 Estrogen signaling pathway 33/1154 131/7206 0.00559843221473 ko05321 Inflammatory bowel disease (IBD) 2/1154 56/7206 0.00579172319231 ko03022 Basal transcription factors 1/1154 44/7206 0.00672994931161 ko04371 Apelin signaling pathway 42/1154 177/7206 0.00673769357936 ko05144 Malaria 1/1154 45/7206 0.00681348137329 ko00071 Fatty acid degradation 1/1154 45/7206 0.00681348137329 ko04612 Antigen processing and presentation 4/1154 77/7206 0.00708717521874 ko04658 Th1 and Th2 cell differentiation 6/1154 96/7206 0.00709332420263 ko03420 Nucleotide excision repair 1/1154 46/7206 0.00713782057816 ko04976 Bile secretion 22/1154 80/7206 0.00840197023802 ko00280 Valine, leucine and isoleucine degradation 2/1154 54/7206 0.00842413155488 ko00480 Glutathione metabolism 2/1154 55/7206 0.00857177098383 ko00240 Pyrimidine metabolism 8/1154 110/7206 0.00857756839214 ko05410 Hypertrophic cardiomyopathy (HCM) 26/1154 100/7206 0.0088542364806 ko00310 Lysine degradation 4/1154 73/7206 0.00974516434635 ko00590 Arachidonic acid metabolism 2/1154 52/7206 0.0123514173287 ko04622 RIG-I-like receptor signaling pathway 3/1154 62/7206 0.0135588503133 ko04510 Focal adhesion 25/1154 240/7206 0.0153655803667 ko04668 TNF signaling pathway 10/1154 120/7206 0.0170412197204 ko04657 IL-17 signaling pathway 6/1154 87/7206 0.0177316735122 ko05133 Pertussis 6/1154 87/7206 0.0177316735122 ko00630 Glyoxylate and dicarboxylate metabolism 1/1154 38/7206 0.0234036858776 ko04210 Apoptosis 18/1154 180/7206 0.0234856367822 ko03018 RNA degradation 6/1154 84/7206 0.0239370257991 ko04930 Type II diabetes mellitus 15/1154 54/7206 0.0245386733735 ko04115 p53 signaling pathway 5/1154 74/7206 0.0253496537288 ko01524 Platinum drug resistance 5/1154 76/7206 0.0260638555825 ko05145 Toxoplasmosis 11/1154 126/7206 0.0264359946565 ko05219 Bladder cancer 2/1154 48/7206 0.0270305536734 ko04620 Toll-like receptor signaling pathway 8/1154 100/7206 0.0271803037349 ko00562 Inositol phosphate metabolism 22/1154 89/7206 0.0290688229359 ko04218 Cellular senescence 18/1154 177/7206 0.0293533026849 ko05131 Shigellosis 6/1154 82/7206 0.032568207947 ko00640 Propanoate metabolism 1/1154 34/7206 0.0334394612432 ko00860 Porphyrin and chlorophyll metabolism 1/1154 34/7206 0.0334394612432 ko04214 Apoptosis - fly 5/1154 72/7206 0.0346650860032 ko04640 Hematopoietic cell lineage 4/1154 64/7206 0.0376615333985 ko04964 Proximal tubule bicarbonate reclamation 9/1154 29/7206 0.0388549586976 ko04932 Non-alcoholic fatty liver disease (NAFLD) 19/1154 182/7206 0.0400364902393 ko04146 Peroxisome 7/1154 89/7206 0.0401419702986 ko04350 TGF-beta signaling pathway 9/1154 103/7206 0.0420075632602 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/1154 135/7206 0.0433107612919 ko04711 Circadian rhythm - fly 5/1154 13/7206 0.0438225271462 ko05120 Epithelial cell signaling in Helicobacter pylori infection 22/1154 92/7206 0.0445664755722 ko04912 GnRH signaling pathway 28/1154 122/7206 0.0452410077594 ko05418 Fluid shear stress and atherosclerosis 18/1154 173/7206 0.0454816263635 ko05215 Prostate cancer 10/1154 111/7206 0.0491118356457