ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	169/1066	423/7206	2.88127214385e-39
ko05033	Nicotine addiction	45/1066	56/7206	5.73606739721e-28
ko04724	Glutamatergic synapse	79/1066	152/7206	1.47051856324e-27
ko04721	Synaptic vesicle cycle	52/1066	80/7206	1.03595596537e-24
ko04727	GABAergic synapse	59/1066	110/7206	9.63919016926e-22
ko05032	Morphine addiction	58/1066	110/7206	6.64740036414e-21
ko04713	Circadian entrainment	62/1066	136/7206	4.14309961827e-18
ko04728	Dopaminergic synapse	73/1066	185/7206	8.26051044234e-17
ko04742	Taste transduction	37/1066	61/7206	1.83112746416e-16
ko04723	Retrograde endocannabinoid signaling	67/1066	175/7206	9.49287662648e-15
ko04744	Phototransduction	26/1066	36/7206	1.15034521698e-14
ko04725	Cholinergic synapse	62/1066	160/7206	5.11373635188e-14
ko04911	Insulin secretion	49/1066	117/7206	7.93315494512e-13
ko04024	cAMP signaling pathway	87/1066	279/7206	1.45715840049e-12
ko04726	Serotonergic synapse	52/1066	137/7206	1.49104912756e-11
ko04740	Olfactory transduction	36/1066	80/7206	7.64421884704e-11
ko05203	Viral carcinogenesis	10/1066	277/7206	1.24799342288e-09
ko05031	Amphetamine addiction	36/1066	91/7206	5.77814248471e-09
ko04020	Calcium signaling pathway	75/1066	265/7206	8.81817374446e-09
ko04970	Salivary secretion	36/1066	95/7206	2.21483214881e-08
ko04921	Oxytocin signaling pathway	62/1066	209/7206	2.61146524611e-08
ko04261	Adrenergic signaling in cardiomyocytes	61/1066	205/7206	3.42283452649e-08
ko03040	Spliceosome	2/1066	145/7206	4.09490034022e-08
ko04720	Long-term potentiation	35/1066	99/7206	3.75198731522e-07
ko05030	Cocaine addiction	28/1066	73/7206	6.09805576901e-07
ko05164	Influenza A	5/1066	167/7206	7.15232982603e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1066	74/7206	8.44741426965e-07
ko04120	Ubiquitin mediated proteolysis	3/1066	138/7206	1.2219128012e-06
ko04360	Axon guidance	62/1066	233/7206	1.94821415394e-06
ko05168	Herpes simplex infection	7/1066	182/7206	2.23877161481e-06
ko04966	Collecting duct acid secretion	14/1066	26/7206	3.73112352123e-06
ko04060	Cytokine-cytokine receptor interaction	8/1066	191/7206	3.76874098858e-06
ko03013	RNA transport	6/1066	166/7206	3.91980900619e-06
ko04971	Gastric acid secretion	32/1066	98/7206	8.51424485285e-06
ko05162	Measles	3/1066	120/7206	1.21662644e-05
ko05322	Systemic lupus erythematosus	6/1066	151/7206	2.364725932e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/1066	182/7206	3.06620007792e-05
ko04141	Protein processing in endoplasmic reticulum	9/1066	184/7206	3.15700313451e-05
ko04010	MAPK signaling pathway	74/1066	321/7206	5.28797235124e-05
ko04621	NOD-like receptor signaling pathway	7/1066	157/7206	5.3825452223e-05
ko04610	Complement and coagulation cascades	1/1066	79/7206	8.23807697418e-05
ko04924	Renin secretion	27/1066	86/7206	8.43526516451e-05
ko04022	cGMP-PKG signaling pathway	53/1066	216/7206	0.000127909403641
ko04925	Aldosterone synthesis and secretion	31/1066	105/7206	0.00013012988922
ko05169	Epstein-Barr virus infection	13/1066	206/7206	0.000202497552268
ko04514	Cell adhesion molecules (CAMs)	35/1066	130/7206	0.000258635856929
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1066	59/7206	0.000261866980716
ko03018	RNA degradation	2/1066	84/7206	0.000285684894396
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1066	14/7206	0.00029190962573
ko04730	Long-term depression	24/1066	78/7206	0.000294274843112
ko04214	Apoptosis - fly	1/1066	72/7206	0.000301325325085
ko04972	Pancreatic secretion	31/1066	111/7206	0.000355774243
ko04260	Cardiac muscle contraction	28/1066	98/7206	0.00044555454765
ko03008	Ribosome biogenesis in eukaryotes	2/1066	79/7206	0.00062913618523
ko04745	Phototransduction - fly	14/1066	38/7206	0.000656851389218
ko04146	Peroxisome	3/1066	89/7206	0.000788279291332
ko05140	Leishmaniasis	2/1066	75/7206	0.000912207550141
ko04540	Gap junction	33/1066	128/7206	0.000969731770238
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1066	79/7206	0.00110619752056
ko05205	Proteoglycans in cancer	22/1066	271/7206	0.00116820688496
ko04064	NF-kappa B signaling pathway	4/1066	96/7206	0.00129983407436
ko05110	Vibrio cholerae infection	19/1066	63/7206	0.00184986878195
ko04964	Proximal tubule bicarbonate reclamation	11/1066	29/7206	0.00187681858343
ko04110	Cell cycle	9/1066	145/7206	0.00194512896527
ko04974	Protein digestion and absorption	26/1066	96/7206	0.00198892427039
ko05161	Hepatitis B	12/1066	173/7206	0.00221615613272
ko00280	Valine, leucine and isoleucine degradation	1/1066	54/7206	0.00321096046898
ko00520	Amino sugar and nucleotide sugar metabolism	1/1066	55/7206	0.00333247648428
ko04014	Ras signaling pathway	59/1066	279/7206	0.00336601757495
ko04976	Bile secretion	22/1066	80/7206	0.00367975607781
ko01200	Carbon metabolism	8/1066	128/7206	0.0036910667385
ko04657	IL-17 signaling pathway	4/1066	87/7206	0.00370602728951
ko00240	Pyrimidine metabolism	6/1066	110/7206	0.00400577020885
ko04640	Hematopoietic cell lineage	2/1066	64/7206	0.00419395831338
ko00590	Arachidonic acid metabolism	1/1066	52/7206	0.00492327866065
ko05145	Toxoplasmosis	8/1066	126/7206	0.00500637508803
ko00330	Arginine and proline metabolism	2/1066	61/7206	0.00610791641623
ko00310	Lysine degradation	3/1066	73/7206	0.00708340307733
ko00260	Glycine, serine and threonine metabolism	1/1066	48/7206	0.00711526195294
ko05166	HTLV-I infection	28/1066	292/7206	0.00897503690685
ko04140	Autophagy - animal	13/1066	164/7206	0.010180668096
ko05144	Malaria	1/1066	45/7206	0.0105909350642
ko00071	Fatty acid degradation	1/1066	45/7206	0.0105909350642
ko04915	Estrogen signaling pathway	30/1066	131/7206	0.0124188324214
ko00480	Glutathione metabolism	2/1066	55/7206	0.0128757387615
ko05321	Inflammatory bowel disease (IBD)	2/1066	56/7206	0.01290555267
ko01524	Platinum drug resistance	4/1066	76/7206	0.0142837963975
ko04612	Antigen processing and presentation	4/1066	77/7206	0.0144202443058
ko00983	Drug metabolism - other enzymes	1/1066	42/7206	0.0157552275177
ko03022	Basal transcription factors	1/1066	44/7206	0.0165101136636
ko04011	MAPK signaling pathway - yeast	2/1066	53/7206	0.0186081101345
ko04668	TNF signaling pathway	9/1066	120/7206	0.0194950556037
ko00561	Glycerolipid metabolism	3/1066	63/7206	0.0197328452901
ko00600	Sphingolipid metabolism	3/1066	63/7206	0.0197328452901
ko04115	p53 signaling pathway	4/1066	74/7206	0.0199974273216
ko05215	Prostate cancer	8/1066	111/7206	0.0213305179736
ko04620	Toll-like receptor signaling pathway	7/1066	100/7206	0.0230986615053
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1066	40/7206	0.0235307194541
ko04138	Autophagy - yeast	5/1066	81/7206	0.0264709168798
ko05131	Shigellosis	5/1066	82/7206	0.0269172536227
ko04750	Inflammatory mediator regulation of TRP channels	27/1066	122/7206	0.027966007246
ko04622	RIG-I-like receptor signaling pathway	3/1066	62/7206	0.0287712014009
ko04950	Maturity onset diabetes of the young	9/1066	29/7206	0.0298607140662
ko05414	Dilated cardiomyopathy	25/1066	112/7206	0.0309368420255
ko00564	Glycerophospholipid metabolism	7/1066	99/7206	0.0311718916924
ko05034	Alcoholism	47/1066	238/7206	0.0325654499376
ko00982	Drug metabolism - cytochrome P450	1/1066	37/7206	0.0347555734113
ko04139	Mitophagy - yeast	1/1066	37/7206	0.0347555734113
ko00630	Glyoxylate and dicarboxylate metabolism	1/1066	38/7206	0.0356205305852
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1066	92/7206	0.0373645428076
ko05204	Chemical carcinogenesis	2/1066	48/7206	0.0388666219422
ko05418	Fluid shear stress and atherosclerosis	16/1066	173/7206	0.038871835061
ko04626	Plant-pathogen interaction	6/1066	18/7206	0.0392584653669
ko05012	Parkinson's disease	14/1066	155/7206	0.0394738643837
ko04978	Mineral absorption	11/1066	40/7206	0.0399081129288
ko04973	Carbohydrate digestion and absorption	11/1066	42/7206	0.0476442570044
ko04350	TGF-beta signaling pathway	8/1066	103/7206	0.0488828477742