ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 168/1071 423/7206 2.39248010931e-38 ko05033 Nicotine addiction 46/1071 56/7206 2.81117366626e-29 ko04724 Glutamatergic synapse 81/1071 152/7206 4.37379101037e-29 ko05032 Morphine addiction 62/1071 110/7206 3.04970596133e-24 ko04727 GABAergic synapse 60/1071 110/7206 1.7272703983e-22 ko04713 Circadian entrainment 68/1071 136/7206 1.79051787844e-22 ko04728 Dopaminergic synapse 80/1071 185/7206 3.90482733979e-21 ko04725 Cholinergic synapse 70/1071 160/7206 5.86646409166e-19 ko04723 Retrograde endocannabinoid signaling 71/1071 175/7206 4.90745102087e-17 ko04024 cAMP signaling pathway 95/1071 279/7206 2.48981023579e-16 ko04721 Synaptic vesicle cycle 42/1071 80/7206 2.61901605283e-15 ko04921 Oxytocin signaling pathway 76/1071 209/7206 6.43808606427e-15 ko04020 Calcium signaling pathway 87/1071 265/7206 8.32348981495e-14 ko04726 Serotonergic synapse 54/1071 137/7206 1.23645333265e-12 ko04744 Phototransduction 24/1071 36/7206 2.22134244602e-12 ko04911 Insulin secretion 48/1071 117/7206 4.04504328221e-12 ko04261 Adrenergic signaling in cardiomyocytes 68/1071 205/7206 2.22439964062e-11 ko05031 Amphetamine addiction 39/1071 91/7206 8.89194432183e-11 ko04742 Taste transduction 30/1071 61/7206 2.20331110632e-10 ko04360 Axon guidance 70/1071 233/7206 1.71429436427e-09 ko03040 Spliceosome 1/1071 145/7206 2.22614983069e-09 ko04720 Long-term potentiation 38/1071 99/7206 6.76435404658e-09 ko04022 cGMP-PKG signaling pathway 64/1071 216/7206 1.64141901822e-08 ko03010 Ribosome 1/1071 129/7206 2.84297065616e-08 ko04970 Salivary secretion 35/1071 95/7206 8.97988319897e-08 ko04070 Phosphatidylinositol signaling system 38/1071 112/7206 3.20464169968e-07 ko04010 MAPK signaling pathway 81/1071 321/7206 7.30144721218e-07 ko05322 Systemic lupus erythematosus 4/1071 151/7206 1.18129920339e-06 ko04925 Aldosterone synthesis and secretion 35/1071 105/7206 2.23381575562e-06 ko05030 Cocaine addiction 27/1071 73/7206 2.43780026728e-06 ko05203 Viral carcinogenesis 16/1071 277/7206 2.54202628826e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 27/1071 74/7206 3.30348689443e-06 ko04740 Olfactory transduction 28/1071 80/7206 7.95757832734e-06 ko04514 Cell adhesion molecules (CAMs) 39/1071 130/7206 8.52448473315e-06 ko04060 Cytokine-cytokine receptor interaction 9/1071 191/7206 1.12098460133e-05 ko04621 NOD-like receptor signaling pathway 6/1071 157/7206 1.15730837244e-05 ko03013 RNA transport 7/1071 166/7206 1.31604324098e-05 ko04730 Long-term depression 27/1071 78/7206 1.36436335157e-05 ko04971 Gastric acid secretion 31/1071 98/7206 2.12921219103e-05 ko04014 Ras signaling pathway 68/1071 279/7206 2.16600656715e-05 ko04072 Phospholipase D signaling pathway 51/1071 197/7206 4.02106897766e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 26/1071 79/7206 4.39814627078e-05 ko04745 Phototransduction - fly 16/1071 38/7206 4.43584812639e-05 ko05168 Herpes simplex infection 10/1071 182/7206 0.000119147050577 ko04064 NF-kappa B signaling pathway 3/1071 96/7206 0.000256821317129 ko04972 Pancreatic secretion 31/1071 111/7206 0.000368679938146 ko04371 Apelin signaling pathway 44/1071 177/7206 0.000374706871224 ko04915 Estrogen signaling pathway 35/1071 131/7206 0.000423369380379 ko04260 Cardiac muscle contraction 28/1071 98/7206 0.000462350719998 ko05164 Influenza A 10/1071 167/7206 0.000562712654088 ko04540 Gap junction 34/1071 128/7206 0.000588164796614 ko04924 Renin secretion 25/1071 86/7206 0.000632008889254 ko03008 Ribosome biogenesis in eukaryotes 2/1071 79/7206 0.000634015599329 ko04141 Protein processing in endoplasmic reticulum 12/1071 184/7206 0.000697851384394 ko04710 Circadian rhythm 15/1071 43/7206 0.000871216469621 ko05140 Leishmaniasis 2/1071 75/7206 0.000908321112904 ko04612 Antigen processing and presentation 2/1071 77/7206 0.000969007295033 ko05414 Dilated cardiomyopathy 30/1071 112/7206 0.00109489344651 ko04750 Inflammatory mediator regulation of TRP channels 32/1071 122/7206 0.00112944482552 ko00562 Inositol phosphate metabolism 25/1071 89/7206 0.00132064422882 ko05169 Epstein-Barr virus infection 15/1071 206/7206 0.00134908748988 ko04120 Ubiquitin mediated proteolysis 8/1071 138/7206 0.00148884740943 ko04110 Cell cycle 9/1071 145/7206 0.00195720352314 ko04015 Rap1 signaling pathway 60/1071 278/7206 0.00248318871931 ko04626 Plant-pathogen interaction 8/1071 18/7206 0.00252671580389 ko04966 Collecting duct acid secretion 10/1071 26/7206 0.00276122953356 ko00480 Glutathione metabolism 1/1071 55/7206 0.00336776333313 ko04610 Complement and coagulation cascades 3/1071 79/7206 0.00354919063481 ko04146 Peroxisome 4/1071 89/7206 0.00381335571828 ko05410 Hypertrophic cardiomyopathy (HCM) 26/1071 100/7206 0.00407778530278 ko05161 Hepatitis B 13/1071 173/7206 0.00463620350849 ko00590 Arachidonic acid metabolism 1/1071 52/7206 0.00496343102001 ko04923 Regulation of lipolysis in adipocytes 21/1071 77/7206 0.00530001353035 ko04930 Type II diabetes mellitus 16/1071 54/7206 0.0057902818865 ko00330 Arginine and proline metabolism 2/1071 61/7206 0.00609123933281 ko04964 Proximal tubule bicarbonate reclamation 10/1071 29/7206 0.00683757763189 ko04711 Circadian rhythm - fly 6/1071 13/7206 0.00714122410102 ko04973 Carbohydrate digestion and absorption 13/1071 42/7206 0.00731700316051 ko04722 Neurotrophin signaling pathway 36/1071 160/7206 0.00929493555973 ko00240 Pyrimidine metabolism 7/1071 110/7206 0.00962303991504 ko00071 Fatty acid degradation 1/1071 45/7206 0.0105724948432 ko03420 Nucleotide excision repair 1/1071 46/7206 0.0108088833731 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1071 14/7206 0.0109477101648 ko05110 Vibrio cholerae infection 17/1071 63/7206 0.0115261642039 ko04657 IL-17 signaling pathway 5/1071 87/7206 0.0142408636574 ko04960 Aldosterone-regulated sodium reabsorption 12/1071 41/7206 0.0147711834597 ko05214 Glioma 20/1071 79/7206 0.0156081669658 ko03022 Basal transcription factors 1/1071 44/7206 0.0166431329372 ko04922 Glucagon signaling pathway 29/1071 128/7206 0.0167325103123 ko05205 Proteoglycans in cancer 27/1071 271/7206 0.0187097825928 ko00280 Valine, leucine and isoleucine degradation 2/1071 54/7206 0.0190895006255 ko05231 Choline metabolism in cancer 30/1071 134/7206 0.0191012180535 ko05016 Huntington's disease 20/1071 215/7206 0.0191205306697 ko04622 RIG-I-like receptor signaling pathway 3/1071 62/7206 0.0197218592176 ko00980 Metabolism of xenobiotics by cytochrome P450 1/1071 40/7206 0.0235651436569 ko00380 Tryptophan metabolism 2/1071 50/7206 0.0267555049998 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/1071 59/7206 0.0275939924065 ko04214 Apoptosis - fly 4/1071 72/7206 0.0284050537743 ko04114 Oocyte meiosis 30/1071 139/7206 0.0297931519546 ko04071 Sphingolipid signaling pathway 34/1071 162/7206 0.0331597548631 ko00982 Drug metabolism - cytochrome P450 1/1071 37/7206 0.0347731575265 ko00270 Cysteine and methionine metabolism 2/1071 47/7206 0.0383365206578 ko03320 PPAR signaling pathway 4/1071 69/7206 0.0389593951212 ko00260 Glycine, serine and threonine metabolism 2/1071 48/7206 0.0390014766878 ko05230 Central carbon metabolism in cancer 19/1071 81/7206 0.0394098117639 ko04217 Necroptosis 17/1071 178/7206 0.0425892961933 ko03018 RNA degradation 6/1071 84/7206 0.0444847330828 ko04115 p53 signaling pathway 5/1071 74/7206 0.0482873841258 ko04350 TGF-beta signaling pathway 8/1071 103/7206 0.0491673305936