ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 45/661 191/7206 1.64984373969e-09 ko04512 ECM-receptor interaction 22/661 79/7206 1.35596001814e-06 ko04020 Calcium signaling pathway 47/661 265/7206 1.00520722578e-05 ko04510 Focal adhesion 42/661 240/7206 3.305366951e-05 ko00643 Styrene degradation 4/661 4/7206 7.02168497908e-05 ko03010 Ribosome 1/661 129/7206 8.43223607972e-05 ko00350 Tyrosine metabolism 11/661 33/7206 0.000104828825309 ko03013 RNA transport 3/661 166/7206 0.000183466241219 ko03040 Spliceosome 2/661 145/7206 0.000201739130995 ko04380 Osteoclast differentiation 26/661 134/7206 0.000203928416857 ko05034 Alcoholism 7/661 238/7206 0.000216130632973 ko00120 Primary bile acid biosynthesis 8/661 20/7206 0.000222821651712 ko05146 Amoebiasis 21/661 99/7206 0.000266100124734 ko04974 Protein digestion and absorption 19/661 96/7206 0.00106321505584 ko04110 Cell cycle 3/661 145/7206 0.00112760501207 ko05145 Toxoplasmosis 23/661 126/7206 0.00144932034175 ko04022 cGMP-PKG signaling pathway 34/661 216/7206 0.00165884602186 ko05203 Viral carcinogenesis 12/661 277/7206 0.00279306663335 ko04111 Cell cycle - yeast 1/661 90/7206 0.00282922973112 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/661 4/7206 0.00286395108612 ko00360 Phenylalanine metabolism 6/661 17/7206 0.00298057392477 ko00140 Steroid hormone biosynthesis 10/661 41/7206 0.00320178566818 ko04933 AGE-RAGE signaling pathway in diabetic complications 23/661 135/7206 0.00362397545122 ko00565 Ether lipid metabolism 10/661 42/7206 0.00386518624072 ko04068 FoxO signaling pathway 27/661 167/7206 0.00387564335189 ko04270 Vascular smooth muscle contraction 25/661 154/7206 0.00433496292133 ko04810 Regulation of actin cytoskeleton 38/661 264/7206 0.00453259893563 ko04710 Circadian rhythm 10/661 43/7206 0.004632789294 ko00380 Tryptophan metabolism 11/661 50/7206 0.00479292840728 ko04672 Intestinal immune network for IgA production 9/661 37/7206 0.00518231448917 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/661 5/7206 0.00667168439139 ko00281 Geraniol degradation 3/661 5/7206 0.00667168439139 ko04064 NF-kappa B signaling pathway 17/661 96/7206 0.0068987067989 ko03008 Ribosome biogenesis in eukaryotes 1/661 79/7206 0.00920722647267 ko00950 Isoquinoline alkaloid biosynthesis 4/661 10/7206 0.0093941526134 ko05322 Systemic lupus erythematosus 5/661 151/7206 0.00944440668367 ko03015 mRNA surveillance pathway 2/661 93/7206 0.0110096028037 ko00051 Fructose and mannose metabolism 9/661 42/7206 0.0122994013842 ko00362 Benzoate degradation 3/661 6/7206 0.0124380129142 ko05410 Hypertrophic cardiomyopathy (HCM) 17/661 100/7206 0.0128418748667 ko04630 Jak-STAT signaling pathway 21/661 132/7206 0.0135397142351 ko04921 Oxytocin signaling pathway 30/661 209/7206 0.0141875770304 ko04640 Hematopoietic cell lineage 12/661 64/7206 0.0144033273052 ko04391 Hippo signaling pathway - fly 2/661 90/7206 0.0157185154157 ko05321 Inflammatory bowel disease (IBD) 11/661 56/7206 0.0160268683293 ko04610 Complement and coagulation cascades 14/661 79/7206 0.0161525196522 ko00982 Drug metabolism - cytochrome P450 8/661 37/7206 0.0169243172944 ko04611 Platelet activation 24/661 163/7206 0.0187689795354 ko04922 Glucagon signaling pathway 20/661 128/7206 0.0188627708648 ko05414 Dilated cardiomyopathy 18/661 112/7206 0.0190600728291 ko05144 Malaria 9/661 45/7206 0.0191128894907 ko05323 Rheumatoid arthritis 15/661 89/7206 0.0238765130839 ko00590 Arachidonic acid metabolism 10/661 52/7206 0.0246920242388 ko04666 Fc gamma R-mediated phagocytosis 19/661 122/7206 0.0248340165371 ko00592 alpha-Linolenic acid metabolism 5/661 19/7206 0.0251063202376 ko05164 Influenza A 24/661 167/7206 0.028533636183 ko04930 Type II diabetes mellitus 10/661 54/7206 0.0286435751862 ko04151 PI3K-Akt signaling pathway 48/661 390/7206 0.0304451679445 ko00480 Glutathione metabolism 10/661 55/7206 0.0310569369435 ko00620 Pyruvate metabolism 9/661 46/7206 0.0336880503748 ko04668 TNF signaling pathway 18/661 120/7206 0.0361890025479 ko05150 Staphylococcus aureus infection 7/661 36/7206 0.0422192640764 ko04658 Th1 and Th2 cell differentiation 15/661 96/7206 0.0470272755949 ko04621 NOD-like receptor signaling pathway 22/661 157/7206 0.0484081065312 ko05230 Central carbon metabolism in cancer 13/661 81/7206 0.0489004619551 ko04960 Aldosterone-regulated sodium reabsorption 8/661 41/7206 0.0494575400704