ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 47/878 191/7206 1.51433684859e-06 ko03013 RNA transport 3/878 166/7206 1.59719585809e-06 ko03010 Ribosome 1/878 129/7206 1.79487650981e-06 ko03040 Spliceosome 2/878 145/7206 2.16914866612e-06 ko00120 Primary bile acid biosynthesis 11/878 20/7206 4.88666513643e-06 ko04710 Circadian rhythm 16/878 43/7206 2.22357322479e-05 ko04070 Phosphatidylinositol signaling system 29/878 112/7206 5.66767009115e-05 ko04650 Natural killer cell mediated cytotoxicity 26/878 97/7206 6.7195512868e-05 ko04110 Cell cycle 4/878 145/7206 8.99960755512e-05 ko04020 Calcium signaling pathway 54/878 265/7206 0.000111180498458 ko05322 Systemic lupus erythematosus 5/878 151/7206 0.000213742584323 ko04610 Complement and coagulation cascades 21/878 79/7206 0.00039229179853 ko04380 Osteoclast differentiation 31/878 134/7206 0.000413390390731 ko04146 Peroxisome 23/878 89/7206 0.000419927963091 ko05340 Primary immunodeficiency 11/878 30/7206 0.000500060320486 ko04072 Phospholipase D signaling pathway 40/878 197/7206 0.000869884370786 ko04022 cGMP-PKG signaling pathway 43/878 216/7206 0.000964393415888 ko03015 mRNA surveillance pathway 2/878 93/7206 0.0011079409984 ko04922 Glucagon signaling pathway 28/878 128/7206 0.00158638797495 ko02010 ABC transporters 12/878 39/7206 0.00168145369923 ko04137 Mitophagy - animal 20/878 82/7206 0.00186550986715 ko00360 Phenylalanine metabolism 7/878 17/7206 0.00250420737661 ko00950 Isoquinoline alkaloid biosynthesis 5/878 10/7206 0.00394753850487 ko03320 PPAR signaling pathway 17/878 69/7206 0.00439973633914 ko00350 Tyrosine metabolism 10/878 33/7206 0.00455707354911 ko00592 alpha-Linolenic acid metabolism 7/878 19/7206 0.00521236038069 ko04640 Hematopoietic cell lineage 16/878 64/7206 0.00580987308926 ko05034 Alcoholism 16/878 238/7206 0.00642175107591 ko05224 Breast cancer 10/878 174/7206 0.0065945807414 ko04630 Jak-STAT signaling pathway 27/878 132/7206 0.00659671568047 ko04014 Ras signaling pathway 49/878 279/7206 0.00861859636413 ko05150 Staphylococcus aureus infection 10/878 36/7206 0.00892219442978 ko04080 Neuroactive ligand-receptor interaction 69/878 423/7206 0.00915048007601 ko05230 Central carbon metabolism in cancer 18/878 81/7206 0.00954766452822 ko04921 Oxytocin signaling pathway 38/878 209/7206 0.00980438267055 ko04113 Meiosis - yeast 2/878 70/7206 0.00987771692075 ko04611 Platelet activation 31/878 163/7206 0.0105048046536 ko04662 B cell receptor signaling pathway 19/878 88/7206 0.0125157969117 ko04725 Cholinergic synapse 30/878 160/7206 0.0141080854866 ko00051 Fructose and mannose metabolism 11/878 42/7206 0.0141511418494 ko05203 Viral carcinogenesis 21/878 277/7206 0.0147146185569 ko04711 Circadian rhythm - fly 5/878 13/7206 0.0147442973482 ko05162 Measles 24/878 120/7206 0.0155790267714 ko04066 HIF-1 signaling pathway 24/878 123/7206 0.0173755514151 ko00680 Methane metabolism 9/878 34/7206 0.0176964622944 ko04621 NOD-like receptor signaling pathway 29/878 157/7206 0.0188709042887 ko00564 Glycerophospholipid metabolism 20/878 99/7206 0.0195782157843 ko04371 Apelin signaling pathway 32/878 177/7206 0.019583966257 ko00071 Fatty acid degradation 11/878 45/7206 0.0196532409111 ko05321 Inflammatory bowel disease (IBD) 13/878 56/7206 0.0210682370734 ko04111 Cell cycle - yeast 4/878 90/7206 0.0218315947949 ko04391 Hippo signaling pathway - fly 4/878 90/7206 0.0218315947949 ko04925 Aldosterone synthesis and secretion 21/878 105/7206 0.0226053157187 ko04659 Th17 cell differentiation 21/878 106/7206 0.0234535088984 ko00362 Benzoate degradation 3/878 6/7206 0.0271348744083 ko00140 Steroid hormone biosynthesis 10/878 41/7206 0.0272544107718 ko05152 Tuberculosis 33/878 187/7206 0.030424274313 ko05231 Choline metabolism in cancer 25/878 134/7206 0.0315324642551 ko05323 Rheumatoid arthritis 18/878 89/7206 0.0318413338938 ko04270 Vascular smooth muscle contraction 28/878 154/7206 0.0330517592003 ko04666 Fc gamma R-mediated phagocytosis 23/878 122/7206 0.0346735856076 ko00970 Aminoacyl-tRNA biosynthesis 1/878 44/7206 0.0373112565761 ko04130 SNARE interactions in vesicular transport 1/878 44/7206 0.0373112565761 ko00982 Drug metabolism - cytochrome P450 9/878 37/7206 0.0381964103152 ko00260 Glycine, serine and threonine metabolism 11/878 48/7206 0.0414727810892 ko04390 Hippo signaling pathway 14/878 188/7206 0.042032266559 ko00330 Arginine and proline metabolism 13/878 61/7206 0.0455843432336 ko00010 Glycolysis / Gluconeogenesis 15/878 74/7206 0.0466013236606 ko00380 Tryptophan metabolism 11/878 50/7206 0.047072346664 ko05140 Leishmaniasis 15/878 75/7206 0.0487951518961 ko04530 Tight junction 18/878 228/7206 0.0497574676925