ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 14/388 30/7206 9.02702251999e-11 ko05150 Staphylococcus aureus infection 13/388 36/7206 1.95047929768e-08 ko04060 Cytokine-cytokine receptor interaction 31/388 191/7206 2.41620772511e-08 ko04610 Complement and coagulation cascades 16/388 79/7206 3.46925961359e-06 ko04380 Osteoclast differentiation 21/388 134/7206 8.24251885799e-06 ko05140 Leishmaniasis 15/388 75/7206 8.26171709719e-06 ko05034 Alcoholism 1/388 238/7206 5.00275896507e-05 ko04612 Antigen processing and presentation 14/388 77/7206 5.09313207908e-05 ko04146 Peroxisome 15/388 89/7206 6.91949816477e-05 ko04672 Intestinal immune network for IgA production 9/388 37/7206 0.000112095771638 ko05145 Toxoplasmosis 18/388 126/7206 0.000126759703736 ko04659 Th17 cell differentiation 16/388 106/7206 0.000155616159021 ko05321 Inflammatory bowel disease (IBD) 11/388 56/7206 0.000158625609307 ko04650 Natural killer cell mediated cytotoxicity 15/388 97/7206 0.000189047459756 ko05152 Tuberculosis 23/388 187/7206 0.000189514130404 ko04137 Mitophagy - animal 13/388 82/7206 0.000391534803428 ko04621 NOD-like receptor signaling pathway 20/388 157/7206 0.000421208819544 ko00120 Primary bile acid biosynthesis 6/388 20/7206 0.000476399334486 ko04360 Axon guidance 2/388 233/7206 0.000520900039791 ko05144 Malaria 9/388 45/7206 0.00054449204031 ko00071 Fatty acid degradation 9/388 45/7206 0.00054449204031 ko05164 Influenza A 20/388 167/7206 0.000694419130946 ko04620 Toll-like receptor signaling pathway 14/388 100/7206 0.000865178056653 ko04660 T cell receptor signaling pathway 16/388 124/7206 0.000943073560528 ko05330 Allograft rejection 6/388 24/7206 0.00137713102947 ko00360 Phenylalanine metabolism 5/388 17/7206 0.00159221833316 ko05310 Asthma 5/388 17/7206 0.00159221833316 ko04658 Th1 and Th2 cell differentiation 13/388 96/7206 0.00178854575408 ko05162 Measles 15/388 120/7206 0.00186445938068 ko04640 Hematopoietic cell lineage 10/388 64/7206 0.00202806055654 ko03050 Proteasome 9/388 54/7206 0.00212840429348 ko00500 Starch and sucrose metabolism 7/388 35/7206 0.00225081061701 ko05133 Pertussis 12/388 87/7206 0.00226675004848 ko00592 alpha-Linolenic acid metabolism 5/388 19/7206 0.00273669399724 ko00362 Benzoate degradation 3/388 6/7206 0.00274219939461 ko05323 Rheumatoid arthritis 12/388 89/7206 0.00275366976323 ko05320 Autoimmune thyroid disease 6/388 29/7206 0.00386888479844 ko04141 Protein processing in endoplasmic reticulum 2/388 184/7206 0.00431758871047 ko04728 Dopaminergic synapse 2/388 185/7206 0.00434981547433 ko03040 Spliceosome 1/388 145/7206 0.00477316924322 ko05224 Breast cancer 2/388 174/7206 0.00610736800774 ko04723 Retrograde endocannabinoid signaling 2/388 175/7206 0.00611153229797 ko05168 Herpes simplex infection 19/388 182/7206 0.00661232534785 ko04666 Fc gamma R-mediated phagocytosis 14/388 122/7206 0.00681864452494 ko04916 Melanogenesis 1/388 142/7206 0.0071860191533 ko00350 Tyrosine metabolism 6/388 33/7206 0.00752307337063 ko03013 RNA transport 2/388 166/7206 0.00867739774421 ko04915 Estrogen signaling pathway 1/388 131/7206 0.0100931081283 ko04713 Circadian entrainment 1/388 136/7206 0.0106757219181 ko03320 PPAR signaling pathway 9/388 69/7206 0.011162128408 ko04722 Neurotrophin signaling pathway 2/388 160/7206 0.0122986709316 ko04725 Cholinergic synapse 2/388 160/7206 0.0122986709316 ko04550 Signaling pathways regulating pluripotency of stem cells 2/388 165/7206 0.0128410797583 ko05203 Viral carcinogenesis 6/388 277/7206 0.0135629110851 ko05332 Graft-versus-host disease 4/388 18/7206 0.0138693267695 ko00950 Isoquinoline alkaloid biosynthesis 3/388 10/7206 0.013998011387 ko01212 Fatty acid metabolism 8/388 60/7206 0.0144039273932 ko03010 Ribosome 1/388 129/7206 0.0155764850104 ko00330 Arginine and proline metabolism 8/388 61/7206 0.0158262533539 ko04514 Cell adhesion molecules (CAMs) 14/388 130/7206 0.015900211261 ko04630 Jak-STAT signaling pathway 14/388 132/7206 0.0166897437455 ko00380 Tryptophan metabolism 7/388 50/7206 0.0167462026416 ko04622 RIG-I-like receptor signaling pathway 8/388 62/7206 0.0173475040152 ko00590 Arachidonic acid metabolism 7/388 52/7206 0.0204706264934 ko04911 Insulin secretion 1/388 117/7206 0.0212446422982 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/388 5/7206 0.0259442908131 ko00281 Geraniol degradation 2/388 5/7206 0.0259442908131 ko05416 Viral myocarditis 7/388 55/7206 0.0270823670454 ko04012 ErbB signaling pathway 1/388 109/7206 0.0305768919083 ko05032 Morphine addiction 1/388 110/7206 0.0307593716365 ko04145 Phagosome 15/388 162/7206 0.0339956856414 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/388 135/7206 0.0341064977106 ko05167 Kaposi's sarcoma-associated herpesvirus infection 17/388 191/7206 0.0346895412701 ko04611 Platelet activation 15/388 163/7206 0.0350854573545 ko00220 Arginine biosynthesis 4/388 24/7206 0.0373882684158 ko04064 NF-kappa B signaling pathway 10/388 96/7206 0.0378398489543 ko01040 Biosynthesis of unsaturated fatty acids 4/388 25/7206 0.0426843264025 ko04914 Progesterone-mediated oocyte maturation 1/388 104/7206 0.0448976917731 ko04925 Aldosterone synthesis and secretion 1/388 105/7206 0.0454486989918 ko00982 Drug metabolism - cytochrome P450 5/388 37/7206 0.0465390644033 ko04150 mTOR signaling pathway 4/388 184/7206 0.0467944544637 ko04390 Hippo signaling pathway 4/388 188/7206 0.0473258299012