ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 172/944 423/7206 5.35404699741e-49 ko05033 Nicotine addiction 42/944 56/7206 3.47703592314e-26 ko04724 Glutamatergic synapse 73/944 152/7206 3.72095315519e-26 ko05032 Morphine addiction 54/944 110/7206 3.60373026985e-20 ko04727 GABAergic synapse 53/944 110/7206 2.39330049394e-19 ko04713 Circadian entrainment 59/944 136/7206 1.31755540549e-18 ko04728 Dopaminergic synapse 68/944 185/7206 1.17020179023e-16 ko04721 Synaptic vesicle cycle 40/944 80/7206 1.32460799275e-15 ko04725 Cholinergic synapse 60/944 160/7206 2.70637061221e-15 ko04911 Insulin secretion 49/944 117/7206 6.55134210838e-15 ko04024 cAMP signaling pathway 85/944 279/7206 1.1655884732e-14 ko04723 Retrograde endocannabinoid signaling 62/944 175/7206 2.02661375602e-14 ko04020 Calcium signaling pathway 78/944 265/7206 1.19176506944e-12 ko04921 Oxytocin signaling pathway 66/944 209/7206 1.559329409e-12 ko04742 Taste transduction 29/944 61/7206 5.61007979807e-11 ko04726 Serotonergic synapse 47/944 137/7206 1.13692533047e-10 ko04261 Adrenergic signaling in cardiomyocytes 61/944 205/7206 2.76534306008e-10 ko05031 Amphetamine addiction 34/944 91/7206 3.60441280607e-09 ko05203 Viral carcinogenesis 9/944 277/7206 1.71487533228e-08 ko04720 Long-term potentiation 34/944 99/7206 4.27239957084e-08 ko04970 Salivary secretion 33/944 95/7206 4.92891444327e-08 ko03040 Spliceosome 1/944 145/7206 5.97755605019e-08 ko04010 MAPK signaling pathway 76/944 321/7206 1.10015859847e-07 ko04360 Axon guidance 60/944 233/7206 1.61625451906e-07 ko05030 Cocaine addiction 27/944 73/7206 1.88902415267e-07 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 28/944 79/7206 3.16508294152e-07 ko04260 Cardiac muscle contraction 32/944 98/7206 4.00287906891e-07 ko04730 Long-term depression 27/944 78/7206 8.82741464286e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 26/944 74/7206 1.01286933005e-06 ko05168 Herpes simplex infection 5/944 182/7206 1.84939181067e-06 ko04060 Cytokine-cytokine receptor interaction 6/944 191/7206 3.31164586163e-06 ko04022 cGMP-PKG signaling pathway 53/944 216/7206 4.60381174471e-06 ko04971 Gastric acid secretion 30/944 98/7206 5.1279022934e-06 ko04514 Cell adhesion molecules (CAMs) 36/944 130/7206 8.50619690576e-06 ko04120 Ubiquitin mediated proteolysis 3/944 138/7206 9.76934319289e-06 ko05164 Influenza A 5/944 167/7206 1.18935397947e-05 ko05322 Systemic lupus erythematosus 4/944 151/7206 1.33597708923e-05 ko04925 Aldosterone synthesis and secretion 30/944 105/7206 2.51729570193e-05 ko04924 Renin secretion 26/944 86/7206 2.84046235631e-05 ko03013 RNA transport 6/944 166/7206 5.72555046326e-05 ko04540 Gap junction 33/944 128/7206 9.31977503134e-05 ko04621 NOD-like receptor signaling pathway 6/944 157/7206 0.000110760283353 ko05169 Epstein-Barr virus infection 10/944 206/7206 0.000134824806124 ko04950 Maturity onset diabetes of the young 12/944 29/7206 0.000145106195402 ko04740 Olfactory transduction 23/944 80/7206 0.000171191241791 ko04972 Pancreatic secretion 29/944 111/7206 0.000179179934481 ko04966 Collecting duct acid secretion 11/944 26/7206 0.000217300704632 ko03008 Ribosome biogenesis in eukaryotes 1/944 79/7206 0.00031509162956 ko04141 Protein processing in endoplasmic reticulum 9/944 184/7206 0.000341146752409 ko05414 Dilated cardiomyopathy 28/944 112/7206 0.000568688736623 ko04976 Bile secretion 22/944 80/7206 0.000600998062188 ko04964 Proximal tubule bicarbonate reclamation 11/944 29/7206 0.00066981509492 ko04214 Apoptosis - fly 1/944 72/7206 0.000704974888885 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/944 14/7206 0.000961246886407 ko05110 Vibrio cholerae infection 18/944 63/7206 0.00100751816587 ko04072 Phospholipase D signaling pathway 42/944 197/7206 0.00119273413575 ko04978 Mineral absorption 13/944 40/7206 0.00121997044309 ko04744 Phototransduction 12/944 36/7206 0.00145786212353 ko00240 Pyrimidine metabolism 4/944 110/7206 0.00146257195758 ko04014 Ras signaling pathway 55/944 279/7206 0.00146825967999 ko05162 Measles 5/944 120/7206 0.00154603988068 ko04610 Complement and coagulation cascades 2/944 79/7206 0.00216173790352 ko01200 Carbon metabolism 6/944 128/7206 0.00222048141151 ko05140 Leishmaniasis 2/944 75/7206 0.0031334781958 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/944 59/7206 0.00322843818696 ko04974 Protein digestion and absorption 23/944 96/7206 0.00333597991209 ko04930 Type II diabetes mellitus 15/944 54/7206 0.00359151534943 ko04146 Peroxisome 3/944 89/7206 0.00379889248293 ko04064 NF-kappa B signaling pathway 4/944 96/7206 0.00563624506885 ko04015 Rap1 signaling pathway 52/944 278/7206 0.00643165540018 ko05410 Hypertrophic cardiomyopathy (HCM) 23/944 100/7206 0.00643965418992 ko04512 ECM-receptor interaction 19/944 79/7206 0.00673662575115 ko00280 Valine, leucine and isoleucine degradation 1/944 54/7206 0.00764929646354 ko04916 Melanogenesis 30/944 142/7206 0.00773633601616 ko00480 Glutathione metabolism 1/944 55/7206 0.00777214671655 ko05321 Inflammatory bowel disease (IBD) 1/944 56/7206 0.00806686362283 ko04915 Estrogen signaling pathway 28/944 131/7206 0.00829744954101 ko04217 Necroptosis 12/944 178/7206 0.00925132868393 ko04612 Antigen processing and presentation 3/944 77/7206 0.0105354282754 ko00590 Arachidonic acid metabolism 1/944 52/7206 0.0115471474568 ko04110 Cell cycle 9/944 145/7206 0.0121598795731 ko04140 Autophagy - animal 11/944 164/7206 0.0133070805532 ko00561 Glycerolipid metabolism 2/944 63/7206 0.0137284430058 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/944 182/7206 0.0139462655549 ko04640 Hematopoietic cell lineage 2/944 64/7206 0.0139616672879 ko05166 HTLV-I infection 25/944 292/7206 0.0167323473543 ko05204 Chemical carcinogenesis 1/944 48/7206 0.0167833308031 ko00380 Tryptophan metabolism 1/944 50/7206 0.0178265536394 ko04371 Apelin signaling pathway 34/944 177/7206 0.017853782295 ko05131 Shigellosis 4/944 82/7206 0.0209947302344 ko03018 RNA degradation 4/944 84/7206 0.0213080470169 ko05205 Proteoglycans in cancer 23/944 271/7206 0.0213917355344 ko03022 Basal transcription factors 1/944 44/7206 0.0247230371205 ko05144 Malaria 1/944 45/7206 0.0248071038367 ko00071 Fatty acid degradation 1/944 45/7206 0.0248071038367 ko03420 Nucleotide excision repair 1/944 46/7206 0.0253742864919 ko04923 Regulation of lipolysis in adipocytes 17/944 77/7206 0.0260938946278 ko04630 Jak-STAT signaling pathway 9/944 132/7206 0.026880181321 ko05161 Hepatitis B 13/944 173/7206 0.0293568495402 ko04138 Autophagy - yeast 4/944 81/7206 0.0294715544507 ko00564 Glycerophospholipid metabolism 6/944 99/7206 0.0349913283205 ko00983 Drug metabolism - other enzymes 1/944 42/7206 0.0366059348178 ko04142 Lysosome 11/944 151/7206 0.0370686330578 ko04657 IL-17 signaling pathway 5/944 87/7206 0.0374933014536 ko05133 Pertussis 5/944 87/7206 0.0374933014536 ko04668 TNF signaling pathway 8/944 120/7206 0.0392681133331 ko04270 Vascular smooth muscle contraction 29/944 154/7206 0.0395474789756 ko01524 Platinum drug resistance 4/944 76/7206 0.039596211274 ko04750 Inflammatory mediator regulation of TRP channels 24/944 122/7206 0.0409067861179 ko04962 Vasopressin-regulated water reabsorption 13/944 58/7206 0.0477904201784