ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 50/543 145/7206 2.67039701337e-21 ko04110 Cell cycle 43/543 145/7206 1.05817459565e-15 ko04111 Cell cycle - yeast 32/543 90/7206 1.85026524202e-14 ko04080 Neuroactive ligand-receptor interaction 2/543 423/7206 1.67049443265e-12 ko03410 Base excision repair 17/543 38/7206 4.129506483e-10 ko03030 DNA replication 17/543 38/7206 4.129506483e-10 ko03013 RNA transport 36/543 166/7206 4.25023931827e-09 ko05202 Transcriptional misregulation in cancer 38/543 188/7206 1.23604983165e-08 ko04550 Signaling pathways regulating pluripotency of stem cells 35/543 165/7206 1.29135790856e-08 ko03015 mRNA surveillance pathway 24/543 93/7206 5.32367722136e-08 ko04020 Calcium signaling pathway 2/543 265/7206 3.20797788957e-07 ko05217 Basal cell carcinoma 19/543 68/7206 3.44882417596e-07 ko04113 Meiosis - yeast 19/543 70/7206 5.66269869882e-07 ko05166 HTLV-I infection 47/543 292/7206 5.95075105875e-07 ko03430 Mismatch repair 10/543 22/7206 1.5345001094e-06 ko04330 Notch signaling pathway 17/543 62/7206 1.91752096834e-06 ko05322 Systemic lupus erythematosus 29/543 151/7206 2.0704868824e-06 ko04310 Wnt signaling pathway 32/543 181/7206 4.59483929773e-06 ko03008 Ribosome biogenesis in eukaryotes 18/543 79/7206 1.6598143159e-05 ko04921 Oxytocin signaling pathway 2/543 209/7206 2.36261832537e-05 ko04723 Retrograde endocannabinoid signaling 1/543 175/7206 2.97406639274e-05 ko04062 Chemokine signaling pathway 2/543 201/7206 3.29339814671e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/543 182/7206 0.000154145224331 ko04072 Phospholipase D signaling pathway 3/543 197/7206 0.000290058957057 ko04144 Endocytosis 10/543 342/7206 0.000325926248463 ko04022 cGMP-PKG signaling pathway 4/543 216/7206 0.000342650106127 ko05224 Breast cancer 27/543 174/7206 0.00035283831659 ko04060 Cytokine-cytokine receptor interaction 3/543 191/7206 0.000411084362173 ko04071 Sphingolipid signaling pathway 2/543 162/7206 0.00045150227382 ko03420 Nucleotide excision repair 11/543 46/7206 0.000471922893786 ko04141 Protein processing in endoplasmic reticulum 3/543 184/7206 0.000579474338146 ko04725 Cholinergic synapse 2/543 160/7206 0.000670099009534 ko04261 Adrenergic signaling in cardiomyocytes 4/543 205/7206 0.000680622185817 ko00310 Lysine degradation 14/543 73/7206 0.000936509441668 ko04670 Leukocyte transendothelial migration 2/543 151/7206 0.000942625292831 ko04270 Vascular smooth muscle contraction 2/543 154/7206 0.000956793837159 ko04390 Hippo signaling pathway 27/543 188/7206 0.00106398916935 ko04024 cAMP signaling pathway 8/543 279/7206 0.00112072173385 ko04611 Platelet activation 3/543 163/7206 0.00235576211877 ko05034 Alcoholism 31/543 238/7206 0.00246296682273 ko04810 Regulation of actin cytoskeleton 8/543 264/7206 0.00275440868494 ko03440 Homologous recombination 9/543 41/7206 0.00289575515134 ko04340 Hedgehog signaling pathway 11/543 58/7206 0.00353134927633 ko04915 Estrogen signaling pathway 2/543 131/7206 0.00401478350462 ko04142 Lysosome 3/543 151/7206 0.00465354624284 ko05160 Hepatitis C 3/543 153/7206 0.00471371835308 ko03018 RNA degradation 14/543 84/7206 0.00506941542909 ko04971 Gastric acid secretion 1/543 98/7206 0.0064813985118 ko05146 Amoebiasis 1/543 99/7206 0.00648930042011 ko04620 Toll-like receptor signaling pathway 1/543 100/7206 0.00654071077763 ko04151 PI3K-Akt signaling pathway 16/543 390/7206 0.00738480380521 ko04912 GnRH signaling pathway 2/543 122/7206 0.0083280117234 ko04120 Ubiquitin mediated proteolysis 19/543 138/7206 0.00871789130868 ko05206 MicroRNAs in cancer 23/543 177/7206 0.00891047581872 ko04970 Salivary secretion 1/543 95/7206 0.0095747782929 ko00240 Pyrimidine metabolism 16/543 110/7206 0.00963252917064 ko04650 Natural killer cell mediated cytotoxicity 1/543 97/7206 0.00995201369637 ko04712 Circadian rhythm - plant 3/543 7/7206 0.0118369130257 ko04911 Insulin secretion 2/543 117/7206 0.0119159598984 ko03460 Fanconi anemia pathway 9/543 51/7206 0.0128525653285 ko04621 NOD-like receptor signaling pathway 4/543 157/7206 0.0133583168393 ko04114 Oocyte meiosis 19/543 139/7206 0.0134018150174 ko05133 Pertussis 1/543 87/7206 0.0137664563071 ko05203 Viral carcinogenesis 32/543 277/7206 0.01422893702 ko05200 Pathways in cancer 51/543 492/7206 0.0167524631526 ko05414 Dilated cardiomyopathy 2/543 112/7206 0.0170147158018 ko04514 Cell adhesion molecules (CAMs) 3/543 130/7206 0.0177845680962 ko04139 Mitophagy - yeast 7/543 37/7206 0.0187871133933 ko04014 Ras signaling pathway 11/543 279/7206 0.0198934154866 ko04728 Dopaminergic synapse 6/543 185/7206 0.0228920090462 ko04660 T cell receptor signaling pathway 3/543 124/7206 0.0245796039533 ko05145 Toxoplasmosis 3/543 126/7206 0.0249784798344 ko04370 VEGF signaling pathway 1/543 77/7206 0.0289792191209 ko04923 Regulation of lipolysis in adipocytes 1/543 77/7206 0.0289792191209 ko04010 MAPK signaling pathway 14/543 321/7206 0.0296258828987 ko04740 Olfactory transduction 1/543 80/7206 0.029835842602 ko04371 Apelin signaling pathway 6/543 177/7206 0.0301495530517 ko05168 Herpes simplex infection 22/543 182/7206 0.0311771619563 ko04722 Neurotrophin signaling pathway 5/543 160/7206 0.0323919481062 ko05132 Salmonella infection 2/543 98/7206 0.0328046736288 ko05100 Bacterial invasion of epithelial cells 2/543 99/7206 0.0329932677331 ko00564 Glycerophospholipid metabolism 2/543 99/7206 0.0329932677331 ko05410 Hypertrophic cardiomyopathy (HCM) 2/543 100/7206 0.0333267647189 ko04668 TNF signaling pathway 3/543 120/7206 0.0342970394531 ko04520 Adherens junction 14/543 103/7206 0.0351969498726 ko04750 Inflammatory mediator regulation of TRP channels 3/543 122/7206 0.0352147406493 ko04914 Progesterone-mediated oocyte maturation 14/543 104/7206 0.036111003338 ko05216 Thyroid cancer 6/543 34/7206 0.0392087439566 ko04530 Tight junction 9/543 228/7206 0.0400318783343 ko05014 Amyotrophic lateral sclerosis (ALS) 1/543 74/7206 0.0427299293987 ko04380 Osteoclast differentiation 4/543 134/7206 0.0455329283769 ko05120 Epithelial cell signaling in Helicobacter pylori infection 2/543 92/7206 0.0460169315776 ko04713 Circadian entrainment 4/543 136/7206 0.0464609871196 ko04070 Phosphatidylinositol signaling system 3/543 112/7206 0.0465241024607 ko05152 Tuberculosis 7/543 187/7206 0.0481759580376