ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	181/1078	423/7206	1.48018778512e-46
ko04724	Glutamatergic synapse	84/1078	152/7206	1.83725198338e-31
ko05033	Nicotine addiction	46/1078	56/7206	3.77576405627e-29
ko05032	Morphine addiction	65/1078	110/7206	7.93700635518e-27
ko04713	Circadian entrainment	73/1078	136/7206	2.24853837923e-26
ko04727	GABAergic synapse	61/1078	110/7206	3.33164232961e-23
ko04728	Dopaminergic synapse	81/1078	185/7206	1.27188177679e-21
ko04721	Synaptic vesicle cycle	49/1078	80/7206	1.86229078771e-21
ko04725	Cholinergic synapse	72/1078	160/7206	3.65386382016e-20
ko04723	Retrograde endocannabinoid signaling	76/1078	175/7206	4.36214646296e-20
ko04911	Insulin secretion	56/1078	117/7206	1.90378573627e-17
ko04024	cAMP signaling pathway	97/1078	279/7206	4.70465970468e-17
ko04742	Taste transduction	37/1078	61/7206	2.66655720295e-16
ko04020	Calcium signaling pathway	89/1078	265/7206	1.03906505885e-14
ko04921	Oxytocin signaling pathway	75/1078	209/7206	2.56572486538e-14
ko04726	Serotonergic synapse	54/1078	137/7206	1.61653528234e-12
ko04261	Adrenergic signaling in cardiomyocytes	69/1078	205/7206	1.06845313307e-11
ko04360	Axon guidance	74/1078	233/7206	6.32137662864e-11
ko05031	Amphetamine addiction	39/1078	91/7206	1.08741627399e-10
ko04970	Salivary secretion	39/1078	95/7206	5.12260568116e-10
ko04720	Long-term potentiation	39/1078	99/7206	2.14941218371e-09
ko03040	Spliceosome	1/1078	145/7206	2.18261674121e-09
ko04925	Aldosterone synthesis and secretion	40/1078	105/7206	4.25003986137e-09
ko04740	Olfactory transduction	33/1078	80/7206	9.62629406035e-09
ko05030	Cocaine addiction	30/1078	73/7206	5.02727843864e-08
ko04971	Gastric acid secretion	36/1078	98/7206	7.60540857502e-08
ko04744	Phototransduction	19/1078	36/7206	1.22619046268e-07
ko04022	cGMP-PKG signaling pathway	61/1078	216/7206	3.18364612117e-07
ko04060	Cytokine-cytokine receptor interaction	7/1078	191/7206	5.13772770759e-07
ko03013	RNA transport	5/1078	166/7206	7.21085666014e-07
ko05168	Herpes simplex infection	7/1078	182/7206	1.53160190389e-06
ko05203	Viral carcinogenesis	16/1078	277/7206	1.8146391579e-06
ko05164	Influenza A	6/1078	167/7206	2.6711127705e-06
ko04514	Cell adhesion molecules (CAMs)	40/1078	130/7206	4.49600378307e-06
ko05322	Systemic lupus erythematosus	5/1078	151/7206	4.55534533764e-06
ko04010	MAPK signaling pathway	78/1078	321/7206	6.29389205582e-06
ko04141	Protein processing in endoplasmic reticulum	9/1078	184/7206	2.17894607865e-05
ko04972	Pancreatic secretion	34/1078	111/7206	2.18013412211e-05
ko04120	Ubiquitin mediated proteolysis	5/1078	138/7206	2.94996381939e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1078	74/7206	4.50464938706e-05
ko04745	Phototransduction - fly	16/1078	38/7206	4.81447868918e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1078	79/7206	4.87273782413e-05
ko04371	Apelin signaling pathway	47/1078	177/7206	6.21133883457e-05
ko04260	Cardiac muscle contraction	30/1078	98/7206	7.77713784311e-05
ko04610	Complement and coagulation cascades	1/1078	79/7206	8.46940738028e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1078	79/7206	8.46940738028e-05
ko04014	Ras signaling pathway	66/1078	279/7206	0.000102656073301
ko04540	Gap junction	36/1078	128/7206	0.000132550350334
ko04966	Collecting duct acid secretion	12/1078	26/7206	0.00014878702776
ko04730	Long-term depression	25/1078	78/7206	0.000149647611064
ko04621	NOD-like receptor signaling pathway	8/1078	157/7206	0.000154937299087
ko04072	Phospholipase D signaling pathway	49/1078	197/7206	0.000229585010441
ko05110	Vibrio cholerae infection	21/1078	63/7206	0.000234261468678
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1078	59/7206	0.000284782397255
ko04924	Renin secretion	26/1078	86/7206	0.000331631136255
ko05414	Dilated cardiomyopathy	31/1078	112/7206	0.000432928822897
ko04750	Inflammatory mediator regulation of TRP channels	33/1078	122/7206	0.000463105069268
ko05169	Epstein-Barr virus infection	14/1078	206/7206	0.000465435085955
ko04110	Cell cycle	8/1078	145/7206	0.000564743686364
ko04612	Antigen processing and presentation	2/1078	77/7206	0.000612986720441
ko04976	Bile secretion	24/1078	80/7206	0.000689188539437
ko05205	Proteoglycans in cancer	22/1078	271/7206	0.000901667718114
ko05140	Leishmaniasis	2/1078	75/7206	0.000907808893852
ko05162	Measles	6/1078	120/7206	0.00106885201383
ko04915	Estrogen signaling pathway	34/1078	131/7206	0.00112442557018
ko04070	Phosphatidylinositol signaling system	30/1078	112/7206	0.00114009304291
ko04064	NF-kappa B signaling pathway	4/1078	96/7206	0.00129910472542
ko04630	Jak-STAT signaling pathway	8/1078	132/7206	0.00198783281498
ko00480	Glutathione metabolism	1/1078	55/7206	0.00211528065359
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1078	14/7206	0.00214807778917
ko04146	Peroxisome	4/1078	89/7206	0.00259752404881
ko00240	Pyrimidine metabolism	6/1078	110/7206	0.00278979073316
ko05161	Hepatitis B	13/1078	173/7206	0.00350291761416
ko04640	Hematopoietic cell lineage	2/1078	64/7206	0.00419214236262
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1078	182/7206	0.00422605543526
ko00590	Arachidonic acid metabolism	1/1078	52/7206	0.00503388962399
ko04930	Type II diabetes mellitus	16/1078	54/7206	0.00597622492964
ko00330	Arginine and proline metabolism	2/1078	61/7206	0.00608704067788
ko04214	Apoptosis - fly	3/1078	72/7206	0.00699237516886
ko05215	Prostate cancer	7/1078	111/7206	0.00700900140351
ko00260	Glycine, serine and threonine metabolism	1/1078	48/7206	0.00712314168794
ko05219	Bladder cancer	1/1078	48/7206	0.00712314168794
ko04964	Proximal tubule bicarbonate reclamation	10/1078	29/7206	0.0071638473313
ko04015	Rap1 signaling pathway	58/1078	278/7206	0.00759585433997
ko04916	Melanogenesis	33/1078	142/7206	0.00845002713086
ko04912	GnRH signaling pathway	29/1078	122/7206	0.0098105085094
ko03022	Basal transcription factors	1/1078	44/7206	0.0105463945399
ko00071	Fatty acid degradation	1/1078	45/7206	0.0105681173418
ko04217	Necroptosis	15/1078	178/7206	0.0105733358367
ko03420	Nucleotide excision repair	1/1078	46/7206	0.0108951518715
ko04626	Plant-pathogen interaction	7/1078	18/7206	0.0115479440164
ko05321	Inflammatory bowel disease (IBD)	2/1078	56/7206	0.0129832815951
ko04658	Th1 and Th2 cell differentiation	6/1078	96/7206	0.0135695040457
ko01524	Platinum drug resistance	4/1078	76/7206	0.0142970087197
ko04657	IL-17 signaling pathway	5/1078	87/7206	0.0143738171257
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1078	100/7206	0.0156346088471
ko00983	Drug metabolism - other enzymes	1/1078	42/7206	0.0156816483483
ko05131	Shigellosis	5/1078	82/7206	0.01920610844
ko00280	Valine, leucine and isoleucine degradation	2/1078	54/7206	0.0192831221033
ko04210	Apoptosis	16/1078	180/7206	0.0194968317743
ko04330	Notch signaling pathway	3/1078	62/7206	0.0196149824244
ko04622	RIG-I-like receptor signaling pathway	3/1078	62/7206	0.0196149824244
ko03018	RNA degradation	5/1078	84/7206	0.0196363712151
ko00310	Lysine degradation	4/1078	73/7206	0.0198341648562
ko05145	Toxoplasmosis	10/1078	126/7206	0.0230257584645
ko04620	Toll-like receptor signaling pathway	7/1078	100/7206	0.0230543388605
ko04923	Regulation of lipolysis in adipocytes	19/1078	77/7206	0.0232897812081
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1078	40/7206	0.0236481249076
ko00140	Steroid hormone biosynthesis	1/1078	41/7206	0.0246566371084
ko00380	Tryptophan metabolism	2/1078	50/7206	0.0267975841375
ko04510	Focal adhesion	24/1078	240/7206	0.0270224993046
ko03320	PPAR signaling pathway	4/1078	69/7206	0.0273182836313
ko04114	Oocyte meiosis	30/1078	139/7206	0.0307785640611
ko05133	Pertussis	6/1078	87/7206	0.0332783449112
ko00982	Drug metabolism - cytochrome P450	1/1078	37/7206	0.0348397552322
ko00620	Pyruvate metabolism	2/1078	46/7206	0.0381937767416
ko04668	TNF signaling pathway	10/1078	120/7206	0.0386785643172
ko04218	Cellular senescence	17/1078	177/7206	0.0424878198754
ko05212	Pancreatic cancer	6/1078	83/7206	0.0443871914948
ko01200	Carbon metabolism	11/1078	128/7206	0.0445210016424
ko04918	Thyroid hormone synthesis	20/1078	86/7206	0.0460041679904
ko04115	p53 signaling pathway	5/1078	74/7206	0.0482680816315
ko04973	Carbohydrate digestion and absorption	11/1078	42/7206	0.0497815818247