ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	26/590	56/7206	2.07262648978e-14
ko04080	Neuroactive ligand-receptor interaction	76/590	423/7206	2.40508836748e-11
ko04724	Glutamatergic synapse	37/590	152/7206	8.39154084315e-10
ko04727	GABAergic synapse	30/590	110/7206	1.93005446116e-09
ko04728	Dopaminergic synapse	40/590	185/7206	7.15277196925e-09
ko04260	Cardiac muscle contraction	27/590	98/7206	9.90686204286e-09
ko04721	Synaptic vesicle cycle	22/590	80/7206	2.43114563072e-07
ko04950	Maturity onset diabetes of the young	12/590	29/7206	1.15067647213e-06
ko05032	Morphine addiction	25/590	110/7206	1.91022853624e-06
ko04713	Circadian entrainment	28/590	136/7206	3.76833904574e-06
ko05030	Cocaine addiction	19/590	73/7206	3.97954746835e-06
ko04723	Retrograde endocannabinoid signaling	33/590	175/7206	4.28083336725e-06
ko05168	Herpes simplex infection	1/590	182/7206	6.10763789797e-06
ko04911	Insulin secretion	25/590	117/7206	6.24432712782e-06
ko04261	Adrenergic signaling in cardiomyocytes	36/590	205/7206	1.18255980466e-05
ko04725	Cholinergic synapse	29/590	160/7206	4.90462714503e-05
ko04512	ECM-receptor interaction	18/590	79/7206	5.063513194e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	17/590	74/7206	7.30401849002e-05
ko04974	Protein digestion and absorption	20/590	96/7206	7.67178441085e-05
ko03040	Spliceosome	1/590	145/7206	9.03106665989e-05
ko05031	Amphetamine addiction	19/590	91/7206	0.000111850450152
ko04514	Cell adhesion molecules (CAMs)	24/590	130/7206	0.000131150514862
ko05410	Hypertrophic cardiomyopathy (HCM)	20/590	100/7206	0.000139350845246
ko04151	PI3K-Akt signaling pathway	53/590	390/7206	0.000189370883078
ko04740	Olfactory transduction	17/590	80/7206	0.000203142070205
ko04621	NOD-like receptor signaling pathway	2/590	157/7206	0.000308221836962
ko05203	Viral carcinogenesis	8/590	277/7206	0.000452951104481
ko00230	Purine metabolism	4/590	194/7206	0.000469728947116
ko04010	MAPK signaling pathway	44/590	321/7206	0.000545228569625
ko05162	Measles	1/590	120/7206	0.000633007203883
ko04060	Cytokine-cytokine receptor interaction	4/590	191/7206	0.000678384347609
ko04726	Serotonergic synapse	23/590	137/7206	0.000774491173536
ko04611	Platelet activation	3/590	163/7206	0.00119963944397
ko04217	Necroptosis	4/590	178/7206	0.00130264885672
ko04964	Proximal tubule bicarbonate reclamation	8/590	29/7206	0.00175891129635
ko04360	Axon guidance	33/590	233/7206	0.00211958502759
ko05322	Systemic lupus erythematosus	3/590	151/7206	0.00231780429965
ko05414	Dilated cardiomyopathy	19/590	112/7206	0.00242377038385
ko05169	Epstein-Barr virus infection	6/590	206/7206	0.00276559544893
ko04914	Progesterone-mediated oocyte maturation	1/590	104/7206	0.00311867875495
ko04742	Taste transduction	12/590	61/7206	0.00340521772393
ko04140	Autophagy - animal	4/590	164/7206	0.00356382874981
ko03013	RNA transport	4/590	166/7206	0.00365581873817
ko04141	Protein processing in endoplasmic reticulum	5/590	184/7206	0.00378154420536
ko00430	Taurine and hypotaurine metabolism	5/590	14/7206	0.00387959101041
ko04668	TNF signaling pathway	2/590	120/7206	0.00390743656076
ko00564	Glycerophospholipid metabolism	1/590	99/7206	0.00455076570371
ko04120	Ubiquitin mediated proteolysis	3/590	138/7206	0.0045515916843
ko04024	cAMP signaling pathway	36/590	279/7206	0.00523863565553
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	14/590	79/7206	0.00556600460418
ko04976	Bile secretion	14/590	80/7206	0.00602155711443
ko04744	Phototransduction	8/590	36/7206	0.00745359602595
ko04657	IL-17 signaling pathway	1/590	87/7206	0.00931083005707
ko04146	Peroxisome	1/590	89/7206	0.00965815525248
ko05224	Breast cancer	24/590	174/7206	0.0109082097808
ko04211	Longevity regulating pathway	3/590	123/7206	0.0124974100618
ko04138	Autophagy - yeast	1/590	81/7206	0.0134802106577
ko04137	Mitophagy - animal	1/590	82/7206	0.0135660270847
ko04978	Mineral absorption	8/590	40/7206	0.014191288452
ko05218	Melanoma	14/590	85/7206	0.014438345464
ko00350	Tyrosine metabolism	7/590	33/7206	0.0155535538263
ko05216	Thyroid cancer	7/590	34/7206	0.0182456135166
ko03008	Ribosome biogenesis in eukaryotes	1/590	79/7206	0.0203922333206
ko04064	NF-kappa B signaling pathway	2/590	96/7206	0.022977391404
ko04144	Endocytosis	17/590	342/7206	0.0256764851141
ko04921	Oxytocin signaling pathway	26/590	209/7206	0.0288754270769
ko05166	HTLV-I infection	14/590	292/7206	0.0289241809489
ko00310	Lysine degradation	1/590	73/7206	0.0290115432579
ko04145	Phagosome	21/590	162/7206	0.0297599596138
ko05140	Leishmaniasis	1/590	75/7206	0.0303117131012
ko00562	Inositol phosphate metabolism	2/590	89/7206	0.0322664832308
ko05145	Toxoplasmosis	4/590	126/7206	0.0328917478069
ko00240	Pyrimidine metabolism	3/590	110/7206	0.0336412295091
ko04070	Phosphatidylinositol signaling system	3/590	112/7206	0.0345258416677
ko04210	Apoptosis	7/590	180/7206	0.0372529654511
ko04720	Long-term potentiation	14/590	99/7206	0.0400034338676
ko04940	Type I diabetes mellitus	6/590	32/7206	0.0426069936507
ko03018	RNA degradation	2/590	84/7206	0.0453727187009
ko05161	Hepatitis B	7/590	173/7206	0.0478727843939
ko04540	Gap junction	17/590	128/7206	0.0483169128727