ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 172/1026 423/7206 1.28720261563e-43 ko04724 Glutamatergic synapse 89/1026 152/7206 9.08078802074e-38 ko05033 Nicotine addiction 48/1026 56/7206 3.99899102059e-33 ko05032 Morphine addiction 68/1026 110/7206 4.48229494125e-31 ko04727 GABAergic synapse 67/1026 110/7206 4.55582364742e-30 ko04713 Circadian entrainment 73/1026 136/7206 9.04467211899e-28 ko04728 Dopaminergic synapse 85/1026 185/7206 6.08768942573e-26 ko04725 Cholinergic synapse 75/1026 160/7206 1.16675716643e-23 ko04723 Retrograde endocannabinoid signaling 79/1026 175/7206 1.49774510434e-23 ko04721 Synaptic vesicle cycle 49/1026 80/7206 2.01505734538e-22 ko04911 Insulin secretion 54/1026 117/7206 5.83043808434e-17 ko04024 cAMP signaling pathway 93/1026 279/7206 1.39918208987e-16 ko04726 Serotonergic synapse 57/1026 137/7206 2.5589064014e-15 ko04261 Adrenergic signaling in cardiomyocytes 72/1026 205/7206 3.4827618328e-14 ko05031 Amphetamine addiction 42/1026 91/7206 1.81107217355e-13 ko04921 Oxytocin signaling pathway 71/1026 209/7206 2.32894888616e-13 ko04020 Calcium signaling pathway 83/1026 265/7206 5.17188657886e-13 ko04720 Long-term potentiation 43/1026 99/7206 1.24619764986e-12 ko04742 Taste transduction 32/1026 61/7206 1.78028324615e-12 ko04925 Aldosterone synthesis and secretion 42/1026 105/7206 5.89218249684e-11 ko04744 Phototransduction 22/1026 36/7206 9.98543701544e-11 ko04971 Gastric acid secretion 38/1026 98/7206 1.40705771646e-09 ko04970 Salivary secretion 37/1026 95/7206 2.00667890056e-09 ko03040 Spliceosome 1/1026 145/7206 9.36617219404e-09 ko05030 Cocaine addiction 29/1026 73/7206 6.74634664912e-08 ko04060 Cytokine-cytokine receptor interaction 5/1026 191/7206 7.86110493668e-08 ko04360 Axon guidance 63/1026 233/7206 1.77250016436e-07 ko04010 MAPK signaling pathway 80/1026 321/7206 1.93136477493e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 28/1026 74/7206 3.79260633433e-07 ko04972 Pancreatic secretion 36/1026 111/7206 7.85591562874e-07 ko04961 Endocrine and other factor-regulated calcium reabsorption 23/1026 59/7206 2.27645924218e-06 ko05203 Viral carcinogenesis 15/1026 277/7206 2.69790102018e-06 ko04022 cGMP-PKG signaling pathway 56/1026 216/7206 4.05474271515e-06 ko05168 Herpes simplex infection 7/1026 182/7206 4.86360966417e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 27/1026 79/7206 5.99959975175e-06 ko04072 Phospholipase D signaling pathway 52/1026 197/7206 6.15553564672e-06 ko05322 Systemic lupus erythematosus 5/1026 151/7206 1.54002853517e-05 ko04260 Cardiac muscle contraction 30/1026 98/7206 2.70173229855e-05 ko04070 Phosphatidylinositol signaling system 33/1026 112/7206 2.72908470234e-05 ko04740 Olfactory transduction 26/1026 80/7206 2.89208246322e-05 ko05110 Vibrio cholerae infection 22/1026 63/7206 2.95224734672e-05 ko03013 RNA transport 7/1026 166/7206 4.00218928454e-05 ko04730 Long-term depression 25/1026 78/7206 5.15811901588e-05 ko04514 Cell adhesion molecules (CAMs) 36/1026 130/7206 6.07469037084e-05 ko04141 Protein processing in endoplasmic reticulum 9/1026 184/7206 6.26160780064e-05 ko04915 Estrogen signaling pathway 36/1026 131/7206 6.63458298813e-05 ko04966 Collecting duct acid secretion 12/1026 26/7206 9.1135468072e-05 ko05414 Dilated cardiomyopathy 32/1026 112/7206 9.37429451804e-05 ko04621 NOD-like receptor signaling pathway 7/1026 157/7206 0.000111235018937 ko04745 Phototransduction - fly 15/1026 38/7206 0.000112258086666 ko04750 Inflammatory mediator regulation of TRP channels 33/1026 122/7206 0.000193203046858 ko04612 Antigen processing and presentation 1/1026 77/7206 0.000201455600272 ko04014 Ras signaling pathway 61/1026 279/7206 0.000437248903961 ko00240 Pyrimidine metabolism 4/1026 110/7206 0.000471833537321 ko04120 Ubiquitin mediated proteolysis 7/1026 138/7206 0.000803211267362 ko03008 Ribosome biogenesis in eukaryotes 2/1026 79/7206 0.00095523093497 ko04640 Hematopoietic cell lineage 1/1026 64/7206 0.000979822520854 ko04110 Cell cycle 8/1026 145/7206 0.00110810115617 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/1026 14/7206 0.00159575940457 ko04976 Bile secretion 22/1026 80/7206 0.00181476611026 ko04540 Gap junction 31/1026 128/7206 0.00208545092876 ko04371 Apelin signaling pathway 40/1026 177/7206 0.00219268648166 ko04918 Thyroid hormone synthesis 23/1026 86/7206 0.00264072356715 ko04062 Chemokine signaling pathway 44/1026 201/7206 0.00282745039642 ko00480 Glutathione metabolism 1/1026 55/7206 0.00328193557646 ko05164 Influenza A 11/1026 167/7206 0.00329318390917 ko04912 GnRH signaling pathway 29/1026 122/7206 0.00392392789818 ko04350 TGF-beta signaling pathway 5/1026 103/7206 0.00402218461219 ko04924 Renin secretion 22/1026 86/7206 0.00471775544713 ko00590 Arachidonic acid metabolism 1/1026 52/7206 0.00490113549261 ko04960 Aldosterone-regulated sodium reabsorption 13/1026 41/7206 0.00517515881168 ko04146 Peroxisome 4/1026 89/7206 0.00540161216438 ko04973 Carbohydrate digestion and absorption 13/1026 42/7206 0.00580412954724 ko05140 Leishmaniasis 3/1026 75/7206 0.00712856446788 ko04064 NF-kappa B signaling pathway 5/1026 96/7206 0.00761083195085 ko05205 Proteoglycans in cancer 24/1026 271/7206 0.00778420935543 ko05410 Hypertrophic cardiomyopathy (HCM) 24/1026 100/7206 0.00871550847462 ko00330 Arginine and proline metabolism 2/1026 61/7206 0.0091052450174 ko04930 Type II diabetes mellitus 15/1026 54/7206 0.00929310686745 ko03018 RNA degradation 4/1026 84/7206 0.0108361620795 ko00260 Glycine, serine and threonine metabolism 1/1026 48/7206 0.0110855786714 ko04217 Necroptosis 14/1026 178/7206 0.0120974952078 ko04270 Vascular smooth muscle contraction 33/1026 154/7206 0.0138800604198 ko04015 Rap1 signaling pathway 54/1026 278/7206 0.0141424299537 ko03320 PPAR signaling pathway 3/1026 69/7206 0.014321084942 ko04916 Melanogenesis 31/1026 142/7206 0.0145029982267 ko04964 Proximal tubule bicarbonate reclamation 9/1026 29/7206 0.0160651416045 ko03022 Basal transcription factors 1/1026 44/7206 0.0160878289746 ko00071 Fatty acid degradation 1/1026 45/7206 0.0163918088238 ko03420 Nucleotide excision repair 1/1026 46/7206 0.0170996508145 ko05231 Choline metabolism in cancer 29/1026 134/7206 0.0173908420519 ko04114 Oocyte meiosis 30/1026 139/7206 0.0189873698808 ko05321 Inflammatory bowel disease (IBD) 2/1026 56/7206 0.0192998916013 ko00140 Steroid hormone biosynthesis 1/1026 41/7206 0.0238235445063 ko04012 ErbB signaling pathway 24/1026 109/7206 0.0261273214164 ko04115 p53 signaling pathway 4/1026 74/7206 0.0281973687662 ko04622 RIG-I-like receptor signaling pathway 3/1026 62/7206 0.0282530474186 ko04722 Neurotrophin signaling pathway 33/1026 160/7206 0.0287930245195 ko04922 Glucagon signaling pathway 27/1026 128/7206 0.029840818103 ko04071 Sphingolipid signaling pathway 33/1026 162/7206 0.0300916796245 ko04923 Regulation of lipolysis in adipocytes 18/1026 77/7206 0.0311615397333 ko04932 Non-alcoholic fatty liver disease (NAFLD) 16/1026 182/7206 0.031461811422 ko04140 Autophagy - animal 14/1026 164/7206 0.0317601903054 ko04626 Plant-pathogen interaction 6/1026 18/7206 0.0332042808878 ko05169 Epstein-Barr virus infection 19/1026 206/7206 0.0338093417433 ko05162 Measles 9/1026 120/7206 0.0340832553875 ko05214 Glioma 18/1026 79/7206 0.0349709509539 ko05161 Hepatitis B 15/1026 173/7206 0.0356741058843 ko00980 Metabolism of xenobiotics by cytochrome P450 1/1026 40/7206 0.0369637673588 ko04137 Mitophagy - animal 5/1026 82/7206 0.0369980633385 ko05145 Toxoplasmosis 10/1026 126/7206 0.0394185569946 ko04210 Apoptosis 16/1026 180/7206 0.0394687439784 ko04214 Apoptosis - fly 4/1026 72/7206 0.0396093949647 ko04657 IL-17 signaling pathway 6/1026 87/7206 0.0452566933927 ko05133 Pertussis 6/1026 87/7206 0.0452566933927 ko05034 Alcoholism 45/1026 238/7206 0.0468838852992 ko05120 Epithelial cell signaling in Helicobacter pylori infection 20/1026 92/7206 0.0493186161149