ko pathway ratio_in_study ratio_in_pop p_value ko04720 Long-term potentiation 22/411 99/7206 2.39021840282e-08 ko04724 Glutamatergic synapse 28/411 152/7206 2.41637899305e-08 ko05031 Amphetamine addiction 21/411 91/7206 2.46929539406e-08 ko04713 Circadian entrainment 26/411 136/7206 3.51729321436e-08 ko04725 Cholinergic synapse 27/411 160/7206 2.83640116066e-07 ko04911 Insulin secretion 22/411 117/7206 5.48406054205e-07 ko04971 Gastric acid secretion 19/411 98/7206 2.03101590868e-06 ko04921 Oxytocin signaling pathway 30/411 209/7206 2.21926943292e-06 ko04745 Phototransduction - fly 11/411 38/7206 5.39016740857e-06 ko04925 Aldosterone synthesis and secretion 19/411 105/7206 5.93559313803e-06 ko04020 Calcium signaling pathway 34/411 265/7206 8.39016690557e-06 ko04728 Dopaminergic synapse 26/411 185/7206 1.57156531985e-05 ko04024 cAMP signaling pathway 34/411 279/7206 2.81896557578e-05 ko04726 Serotonergic synapse 20/411 137/7206 8.81447858356e-05 ko04922 Glucagon signaling pathway 19/411 128/7206 0.000105084025818 ko04912 GnRH signaling pathway 18/411 122/7206 0.000172149522234 ko04750 Inflammatory mediator regulation of TRP channels 18/411 122/7206 0.000172149522234 ko04022 cGMP-PKG signaling pathway 26/411 216/7206 0.000260153092725 ko04080 Neuroactive ligand-receptor interaction 42/411 423/7206 0.000328187122387 ko04626 Plant-pathogen interaction 6/411 18/7206 0.000342309423873 ko04360 Axon guidance 27/411 233/7206 0.000427168834656 ko04916 Melanogenesis 19/411 142/7206 0.000636189857553 ko04261 Adrenergic signaling in cardiomyocytes 24/411 205/7206 0.00065218150067 ko04970 Salivary secretion 14/411 95/7206 0.000904608476403 ko04114 Oocyte meiosis 18/411 139/7206 0.00113358025545 ko05214 Glioma 12/411 79/7206 0.00158671369317 ko04070 Phosphatidylinositol signaling system 15/411 112/7206 0.00163631423056 ko04721 Synaptic vesicle cycle 12/411 80/7206 0.00177298271851 ko04740 Olfactory transduction 12/411 80/7206 0.00177298271851 ko04371 Apelin signaling pathway 20/411 177/7206 0.0028411918875 ko00010 Glycolysis / Gluconeogenesis 11/411 74/7206 0.00292876084952 ko03040 Spliceosome 1/411 145/7206 0.00325450636525 ko04514 Cell adhesion molecules (CAMs) 16/411 130/7206 0.00327065573447 ko04924 Renin secretion 12/411 86/7206 0.00330472970499 ko04120 Ubiquitin mediated proteolysis 1/411 138/7206 0.00474216361861 ko04540 Gap junction 15/411 128/7206 0.00650243537823 ko04742 Taste transduction 9/411 61/7206 0.00721968169298 ko04014 Ras signaling pathway 27/411 279/7206 0.00771824380189 ko04960 Aldosterone-regulated sodium reabsorption 7/411 41/7206 0.00776656541544 ko05014 Amyotrophic lateral sclerosis (ALS) 10/411 74/7206 0.00884037248822 ko00051 Fructose and mannose metabolism 7/411 42/7206 0.0088752767679 ko04919 Thyroid hormone signaling pathway 16/411 143/7206 0.00924269449369 ko04710 Circadian rhythm 7/411 43/7206 0.0100958290943 ko04727 GABAergic synapse 13/411 110/7206 0.010976977646 ko00680 Methane metabolism 6/411 34/7206 0.0114347103847 ko05168 Herpes simplex infection 3/411 182/7206 0.0137296529688 ko04966 Collecting duct acid secretion 5/411 26/7206 0.01432721717 ko03320 PPAR signaling pathway 9/411 69/7206 0.0158218991926 ko04066 HIF-1 signaling pathway 14/411 123/7206 0.0158784932154 ko04662 B cell receptor signaling pathway 11/411 88/7206 0.016507105413 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/411 59/7206 0.0179794842061 ko00643 Styrene degradation 2/411 4/7206 0.0180308875421 ko04310 Wnt signaling pathway 18/411 181/7206 0.0211918932772 ko04964 Proximal tubule bicarbonate reclamation 5/411 29/7206 0.0224942181635 ko05230 Central carbon metabolism in cancer 10/411 81/7206 0.0246104997054 ko04650 Natural killer cell mediated cytotoxicity 11/411 97/7206 0.0248951979028 ko04072 Phospholipase D signaling pathway 19/411 197/7206 0.0271315841147 ko00140 Steroid hormone biosynthesis 6/411 41/7206 0.0273811748988 ko04213 Longevity regulating pathway - multiple species 10/411 86/7206 0.0300532202996 ko04918 Thyroid hormone synthesis 10/411 86/7206 0.0300532202996 ko04012 ErbB signaling pathway 12/411 109/7206 0.0330696111243 ko00030 Pentose phosphate pathway 5/411 32/7206 0.0331967999348 ko05032 Morphine addiction 12/411 110/7206 0.0338575808322 ko04972 Pancreatic secretion 12/411 111/7206 0.0347435234488 ko04141 Protein processing in endoplasmic reticulum 4/411 184/7206 0.0347740987726 ko04270 Vascular smooth muscle contraction 15/411 154/7206 0.0350512958705 ko05030 Cocaine addiction 9/411 73/7206 0.0356596299472 ko04370 VEGF signaling pathway 9/411 77/7206 0.0408826941359 ko04730 Long-term depression 9/411 78/7206 0.0425701096373 ko04015 Rap1 signaling pathway 24/411 278/7206 0.0461408522834 ko04976 Bile secretion 9/411 80/7206 0.0464055321846