ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	146/899	423/7206	3.18383098369e-34
ko04724	Glutamatergic synapse	80/899	152/7206	9.87197580154e-34
ko05033	Nicotine addiction	44/899	56/7206	8.30349869477e-30
ko04727	GABAergic synapse	62/899	110/7206	1.52753245976e-28
ko05032	Morphine addiction	59/899	110/7206	1.16694976984e-25
ko04713	Circadian entrainment	65/899	136/7206	1.88408331971e-24
ko04723	Retrograde endocannabinoid signaling	72/899	175/7206	4.04177404451e-22
ko04728	Dopaminergic synapse	71/899	185/7206	9.14555428646e-20
ko04725	Cholinergic synapse	61/899	160/7206	5.82353792382e-17
ko04744	Phototransduction	26/899	36/7206	1.67218829722e-16
ko04911	Insulin secretion	48/899	117/7206	4.73865201685e-15
ko04024	cAMP signaling pathway	79/899	279/7206	3.99742870377e-13
ko04020	Calcium signaling pathway	76/899	265/7206	7.06155528243e-13
ko04721	Synaptic vesicle cycle	35/899	80/7206	2.71448699879e-12
ko04726	Serotonergic synapse	48/899	137/7206	5.14079153036e-12
ko04740	Olfactory transduction	34/899	80/7206	1.51139291214e-11
ko04921	Oxytocin signaling pathway	61/899	209/7206	6.84455675828e-11
ko04742	Taste transduction	28/899	61/7206	1.06208845144e-10
ko05031	Amphetamine addiction	35/899	91/7206	2.18956076682e-10
ko04720	Long-term potentiation	35/899	99/7206	3.12480251466e-09
ko04261	Adrenergic signaling in cardiomyocytes	56/899	205/7206	5.38784077047e-09
ko04970	Salivary secretion	32/899	95/7206	5.61142645587e-08
ko05203	Viral carcinogenesis	9/899	277/7206	7.79438467926e-08
ko04925	Aldosterone synthesis and secretion	33/899	105/7206	2.2683879969e-07
ko05030	Cocaine addiction	26/899	73/7206	2.84388289037e-07
ko03040	Spliceosome	2/899	145/7206	1.41338737491e-06
ko05162	Measles	1/899	120/7206	4.01750384223e-06
ko05322	Systemic lupus erythematosus	3/899	151/7206	4.81910777378e-06
ko03013	RNA transport	4/899	166/7206	6.94830028433e-06
ko04010	MAPK signaling pathway	68/899	321/7206	8.36063881576e-06
ko04745	Phototransduction - fly	15/899	38/7206	2.33871482452e-05
ko05164	Influenza A	5/899	167/7206	2.49672285702e-05
ko04972	Pancreatic secretion	30/899	111/7206	2.96003747153e-05
ko04072	Phospholipase D signaling pathway	45/899	197/7206	4.08100984231e-05
ko04971	Gastric acid secretion	27/899	98/7206	4.3787854812e-05
ko04022	cGMP-PKG signaling pathway	48/899	216/7206	5.62175300668e-05
ko04110	Cell cycle	4/899	145/7206	6.12381228294e-05
ko05169	Epstein-Barr virus infection	9/899	206/7206	9.884155153e-05
ko04514	Cell adhesion molecules (CAMs)	32/899	130/7206	0.000128444677496
ko04260	Cardiac muscle contraction	26/899	98/7206	0.000144614427932
ko05205	Proteoglycans in cancer	15/899	271/7206	0.0001600573776
ko04730	Long-term depression	22/899	78/7206	0.00017407637789
ko05168	Herpes simplex infection	8/899	182/7206	0.00035994751717
ko03008	Ribosome biogenesis in eukaryotes	1/899	79/7206	0.000490649275085
ko04120	Ubiquitin mediated proteolysis	5/899	138/7206	0.000595431515067
ko04141	Protein processing in endoplasmic reticulum	9/899	184/7206	0.000652514954947
ko04070	Phosphatidylinositol signaling system	27/899	112/7206	0.000715848262169
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/899	182/7206	0.000886990582009
ko04621	NOD-like receptor signaling pathway	7/899	157/7206	0.000890571364246
ko04630	Jak-STAT signaling pathway	5/899	132/7206	0.00119633098921
ko05218	Melanoma	2/899	85/7206	0.00153381763669
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/899	79/7206	0.00161458809714
ko05224	Breast cancer	9/899	174/7206	0.00161816292094
ko04964	Proximal tubule bicarbonate reclamation	10/899	29/7206	0.00186214471311
ko05014	Amyotrophic lateral sclerosis (ALS)	19/899	74/7206	0.00200124063443
ko05166	HTLV-I infection	20/899	292/7206	0.00201622207947
ko05215	Prostate cancer	4/899	111/7206	0.00209759903989
ko05161	Hepatitis B	9/899	173/7206	0.0022260410757
ko04540	Gap junction	28/899	128/7206	0.00264175250344
ko04810	Regulation of actin cytoskeleton	18/899	264/7206	0.00315898414832
ko04610	Complement and coagulation cascades	2/899	79/7206	0.00323007351492
ko04510	Focal adhesion	16/899	240/7206	0.0038509418703
ko04150	mTOR signaling pathway	11/899	184/7206	0.00457210137111
ko04924	Renin secretion	20/899	86/7206	0.00472214134717
ko04612	Antigen processing and presentation	2/899	77/7206	0.004754968003
ko05200	Pathways in cancer	42/899	492/7206	0.00570784590237
ko04930	Type II diabetes mellitus	14/899	54/7206	0.00602071889691
ko04014	Ras signaling pathway	50/899	279/7206	0.00716148667866
ko05140	Leishmaniasis	2/899	75/7206	0.00717055819115
ko05220	Chronic myeloid leukemia	3/899	85/7206	0.0076416106036
ko04218	Cellular senescence	11/899	177/7206	0.00787891995964
ko05414	Dilated cardiomyopathy	24/899	112/7206	0.00858634862344
ko04976	Bile secretion	18/899	80/7206	0.010215454625
ko05131	Shigellosis	3/899	82/7206	0.0108270999205
ko04140	Autophagy - animal	10/899	164/7206	0.0114206990917
ko04064	NF-kappa B signaling pathway	4/899	96/7206	0.0116497440526
ko00280	Valine, leucine and isoleucine degradation	1/899	54/7206	0.0116776346079
ko05416	Viral myocarditis	1/899	55/7206	0.011980691715
ko04142	Lysosome	9/899	151/7206	0.0122279161992
ko04060	Cytokine-cytokine receptor interaction	13/899	191/7206	0.0142208600331
ko05217	Basal cell carcinoma	2/899	68/7206	0.0146251371612
ko00562	Inositol phosphate metabolism	19/899	89/7206	0.0151918830861
ko04210	Apoptosis	12/899	180/7206	0.015841519948
ko04710	Circadian rhythm	11/899	43/7206	0.0173311761596
ko00590	Arachidonic acid metabolism	1/899	52/7206	0.0178408376735
ko00240	Pyrimidine metabolism	6/899	110/7206	0.019864239844
ko05016	Huntington's disease	16/899	215/7206	0.0209388164226
ko04620	Toll-like receptor signaling pathway	5/899	100/7206	0.0210551660512
ko04657	IL-17 signaling pathway	4/899	87/7206	0.021436291682
ko05133	Pertussis	4/899	87/7206	0.021436291682
ko05130	Pathogenic Escherichia coli infection	3/899	77/7206	0.0221543038855
ko04550	Signaling pathways regulating pluripotency of stem cells	11/899	165/7206	0.0226937384878
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/899	14/7206	0.0227378988093
ko00910	Nitrogen metabolism	6/899	19/7206	0.0239493313277
ko00620	Pyruvate metabolism	1/899	46/7206	0.0252434908188
ko03420	Nucleotide excision repair	1/899	46/7206	0.0252434908188
ko04750	Inflammatory mediator regulation of TRP channels	24/899	122/7206	0.0256629541457
ko05219	Bladder cancer	1/899	48/7206	0.0256639027231
ko05418	Fluid shear stress and atherosclerosis	12/899	173/7206	0.0261054595337
ko04978	Mineral absorption	10/899	40/7206	0.0268818893049
ko05211	Renal cell carcinoma	5/899	96/7206	0.0283693103795
ko04145	Phagosome	11/899	162/7206	0.029374228535
ko05212	Pancreatic cancer	4/899	83/7206	0.0294091339511
ko04918	Thyroid hormone synthesis	18/899	86/7206	0.0306851569994
ko05202	Transcriptional misregulation in cancer	14/899	188/7206	0.0332327055113
ko04931	Insulin resistance	9/899	137/7206	0.0357303122725
ko04966	Collecting duct acid secretion	7/899	26/7206	0.0357504265775
ko03022	Basal transcription factors	1/899	44/7206	0.0371975194252
ko00071	Fatty acid degradation	1/899	45/7206	0.0379963367705
ko04062	Chemokine signaling pathway	35/899	201/7206	0.0389835061624
ko00480	Glutathione metabolism	2/899	55/7206	0.0408981069643
ko05321	Inflammatory bowel disease (IBD)	2/899	56/7206	0.0409337110772
ko04974	Protein digestion and absorption	19/899	96/7206	0.0412241905191
ko03320	PPAR signaling pathway	3/899	69/7206	0.0419011413763
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/899	59/7206	0.0441161829553
ko04915	Estrogen signaling pathway	24/899	131/7206	0.0454719841485
ko05034	Alcoholism	40/899	238/7206	0.04562363057