ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1247	423/7206	7.81808212989e-56
ko04724	Glutamatergic synapse	93/1247	152/7206	1.96615447444e-34
ko05033	Nicotine addiction	50/1247	56/7206	3.93424707232e-32
ko04713	Circadian entrainment	78/1247	136/7206	2.31714841886e-26
ko04727	GABAergic synapse	68/1247	110/7206	8.64213695579e-26
ko05032	Morphine addiction	68/1247	110/7206	8.64213695579e-26
ko04721	Synaptic vesicle cycle	55/1247	80/7206	1.91328489827e-24
ko04728	Dopaminergic synapse	89/1247	185/7206	1.2069579605e-22
ko04725	Cholinergic synapse	78/1247	160/7206	2.05959745518e-20
ko04020	Calcium signaling pathway	105/1247	265/7206	1.57624571695e-18
ko04723	Retrograde endocannabinoid signaling	79/1247	175/7206	4.06307645179e-18
ko04024	cAMP signaling pathway	107/1247	279/7206	1.34093564296e-17
ko04742	Taste transduction	39/1247	61/7206	5.04026069372e-16
ko04744	Phototransduction	28/1247	36/7206	2.61766743813e-15
ko04726	Serotonergic synapse	63/1247	137/7206	3.72368685831e-15
ko04921	Oxytocin signaling pathway	83/1247	209/7206	9.29883918954e-15
ko04911	Insulin secretion	56/1247	117/7206	1.52337755925e-14
ko04720	Long-term potentiation	49/1247	99/7206	1.36051992783e-13
ko05031	Amphetamine addiction	45/1247	91/7206	1.42931035075e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1247	205/7206	6.70320221162e-12
ko04970	Salivary secretion	45/1247	95/7206	9.63401200138e-12
ko03040	Spliceosome	1/1247	145/7206	4.29907578707e-11
ko04740	Olfactory transduction	37/1247	80/7206	1.59300577433e-09
ko04360	Axon guidance	76/1247	233/7206	9.22533533357e-09
ko05203	Viral carcinogenesis	16/1247	277/7206	9.25424377383e-09
ko04925	Aldosterone synthesis and secretion	42/1247	105/7206	2.87392703237e-08
ko04060	Cytokine-cytokine receptor interaction	8/1247	191/7206	5.12205844816e-08
ko05030	Cocaine addiction	32/1247	73/7206	9.86205207631e-08
ko04971	Gastric acid secretion	39/1247	98/7206	1.06559235604e-07
ko05168	Herpes simplex infection	8/1247	182/7206	1.47784495041e-07
ko04022	cGMP-PKG signaling pathway	68/1247	216/7206	2.13719642341e-07
ko04540	Gap junction	46/1247	128/7206	3.49319125422e-07
ko03013	RNA transport	7/1247	166/7206	3.78128518179e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1247	74/7206	2.59940178164e-06
ko04924	Renin secretion	33/1247	86/7206	3.89168135277e-06
ko04966	Collecting duct acid secretion	15/1247	26/7206	3.95171439206e-06
ko04621	NOD-like receptor signaling pathway	8/1247	157/7206	5.57903591603e-06
ko04120	Ubiquitin mediated proteolysis	6/1247	138/7206	6.24692505788e-06
ko04260	Cardiac muscle contraction	35/1247	98/7206	1.00813200195e-05
ko04514	Cell adhesion molecules (CAMs)	43/1247	130/7206	1.02680758995e-05
ko04010	MAPK signaling pathway	86/1247	321/7206	1.45850707506e-05
ko05322	Systemic lupus erythematosus	8/1247	151/7206	1.63803675657e-05
ko04745	Phototransduction - fly	18/1247	38/7206	1.74350933825e-05
ko05164	Influenza A	10/1247	167/7206	1.80158742772e-05
ko04070	Phosphatidylinositol signaling system	38/1247	112/7206	2.112676437e-05
ko04730	Long-term depression	29/1247	78/7206	2.64313434166e-05
ko05110	Vibrio cholerae infection	25/1247	63/7206	2.68381137197e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1247	59/7206	3.14892030346e-05
ko04141	Protein processing in endoplasmic reticulum	13/1247	184/7206	6.6407619253e-05
ko04610	Complement and coagulation cascades	2/1247	79/7206	7.03645479575e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1247	79/7206	7.03645479575e-05
ko05169	Epstein-Barr virus infection	16/1247	206/7206	0.000109361767317
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1247	79/7206	0.000120214256989
ko04110	Cell cycle	9/1247	145/7206	0.000132638153661
ko05140	Leishmaniasis	2/1247	75/7206	0.000159990041843
ko04915	Estrogen signaling pathway	40/1247	131/7206	0.000161918153229
ko04072	Phospholipase D signaling pathway	55/1247	197/7206	0.000172242687683
ko04064	NF-kappa B signaling pathway	4/1247	96/7206	0.000183197321185
ko04972	Pancreatic secretion	35/1247	111/7206	0.000203726566933
ko04014	Ras signaling pathway	72/1247	279/7206	0.000261898274958
ko04626	Plant-pathogen interaction	10/1247	18/7206	0.000264711025789
ko04976	Bile secretion	27/1247	80/7206	0.000298400634955
ko05414	Dilated cardiomyopathy	35/1247	112/7206	0.000339174723596
ko05162	Measles	7/1247	120/7206	0.000343789588916
ko04750	Inflammatory mediator regulation of TRP channels	37/1247	122/7206	0.000384695925534
ko00480	Glutathione metabolism	1/1247	55/7206	0.000530373741921
ko04371	Apelin signaling pathway	49/1247	177/7206	0.000555466762084
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1247	14/7206	0.00088053936179
ko00590	Arachidonic acid metabolism	1/1247	52/7206	0.00128203126411
ko00240	Pyrimidine metabolism	7/1247	110/7206	0.00130157437322
ko05205	Proteoglycans in cancer	28/1247	271/7206	0.00136035930666
ko04214	Apoptosis - fly	3/1247	72/7206	0.00143228384352
ko05161	Hepatitis B	15/1247	173/7206	0.00151062425593
ko04146	Peroxisome	5/1247	89/7206	0.00170992263016
ko04612	Antigen processing and presentation	4/1247	77/7206	0.002285468822
ko03420	Nucleotide excision repair	1/1247	46/7206	0.00278945312178
ko03018	RNA degradation	5/1247	84/7206	0.00339113339886
ko04923	Regulation of lipolysis in adipocytes	24/1247	77/7206	0.00343448853144
ko05321	Inflammatory bowel disease (IBD)	2/1247	56/7206	0.0037872511414
ko03022	Basal transcription factors	1/1247	44/7206	0.00424476716016
ko05166	HTLV-I infection	33/1247	292/7206	0.0044198155716
ko05144	Malaria	1/1247	45/7206	0.00446291680891
ko00071	Fatty acid degradation	1/1247	45/7206	0.00446291680891
ko04622	RIG-I-like receptor signaling pathway	3/1247	62/7206	0.00622252112495
ko04657	IL-17 signaling pathway	6/1247	87/7206	0.00654509038111
ko04912	GnRH signaling pathway	33/1247	122/7206	0.00739376763964
ko04350	TGF-beta signaling pathway	8/1247	103/7206	0.00817020260304
ko05145	Toxoplasmosis	11/1247	126/7206	0.00856017139593
ko01524	Platinum drug resistance	5/1247	76/7206	0.00923384694003
ko00630	Glyoxylate and dicarboxylate metabolism	1/1247	38/7206	0.00958443908451
ko03410	Base excision repair	1/1247	38/7206	0.00958443908451
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1247	40/7206	0.00996381198846
ko04964	Proximal tubule bicarbonate reclamation	11/1247	29/7206	0.0106131177258
ko05131	Shigellosis	6/1247	82/7206	0.0123372623173
ko04115	p53 signaling pathway	5/1247	74/7206	0.0128155642674
ko04922	Glucagon signaling pathway	33/1247	128/7206	0.0132491652993
ko04916	Melanogenesis	36/1247	142/7206	0.0134917051943
ko00982	Drug metabolism - cytochrome P450	1/1247	37/7206	0.0145457066734
ko04668	TNF signaling pathway	11/1247	120/7206	0.0147220810906
ko05231	Choline metabolism in cancer	34/1247	134/7206	0.0154914343328
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1247	100/7206	0.015659357288
ko04330	Notch signaling pathway	4/1247	62/7206	0.0181991421855
ko00310	Lysine degradation	5/1247	73/7206	0.0182749911645
ko05034	Alcoholism	55/1247	238/7206	0.0185994702492
ko04640	Hematopoietic cell lineage	4/1247	64/7206	0.0186246890687
ko04015	Rap1 signaling pathway	63/1247	278/7206	0.0189015566825
ko04658	Th1 and Th2 cell differentiation	8/1247	96/7206	0.0199149053766
ko04630	Jak-STAT signaling pathway	13/1247	132/7206	0.0199780108487
ko05133	Pertussis	7/1247	87/7206	0.0214796864692
ko04620	Toll-like receptor signaling pathway	9/1247	100/7206	0.0236134599132
ko03320	PPAR signaling pathway	5/1247	69/7206	0.0243357125322
ko05418	Fluid shear stress and atherosclerosis	19/1247	173/7206	0.0249525586005
ko00330	Arginine and proline metabolism	4/1247	61/7206	0.0256121341242
ko05132	Salmonella infection	9/1247	98/7206	0.0310129039917
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1247	15/7206	0.0323195891135
ko05206	MicroRNAs in cancer	20/1247	177/7206	0.0340989215166
ko05222	Small cell lung cancer	8/1247	89/7206	0.034386130034
ko05214	Glioma	21/1247	79/7206	0.0354906963656
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1247	92/7206	0.0360482398461
ko00140	Steroid hormone biosynthesis	2/1247	41/7206	0.036067309132
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1247	182/7206	0.0369455529138
ko04918	Thyroid hormone synthesis	22/1247	86/7206	0.0452125529792
ko00600	Sphingolipid metabolism	5/1247	63/7206	0.0453319414607
ko00562	Inositol phosphate metabolism	23/1247	89/7206	0.0467552584349
ko05010	Alzheimer's disease	46/1247	202/7206	0.0469140447943
ko04930	Type II diabetes mellitus	15/1247	54/7206	0.0472495842872
ko05320	Autoimmune thyroid disease	1/1247	29/7206	0.047921980121
ko04142	Lysosome	17/1247	151/7206	0.0498514579921