ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 137/887 423/7206 2.04624787672e-29 ko04724 Glutamatergic synapse 69/887 152/7206 1.36314403854e-24 ko05033 Nicotine addiction 38/887 56/7206 3.09024271217e-22 ko04721 Synaptic vesicle cycle 44/887 80/7206 3.17581249514e-20 ko04728 Dopaminergic synapse 71/887 185/7206 4.19548770892e-20 ko05032 Morphine addiction 50/887 110/7206 3.89062137652e-18 ko04713 Circadian entrainment 56/887 136/7206 1.00815161293e-17 ko04727 GABAergic synapse 48/887 110/7206 1.42459912805e-16 ko04725 Cholinergic synapse 59/887 160/7206 6.23522340055e-16 ko04723 Retrograde endocannabinoid signaling 60/887 175/7206 1.68923001017e-14 ko04024 cAMP signaling pathway 79/887 279/7206 2.26972899283e-13 ko04911 Insulin secretion 44/887 117/7206 1.56550373018e-12 ko05031 Amphetamine addiction 35/887 91/7206 1.50216193909e-10 ko04921 Oxytocin signaling pathway 59/887 209/7206 2.97766524903e-10 ko04261 Adrenergic signaling in cardiomyocytes 58/887 205/7206 3.95217944422e-10 ko04726 Serotonergic synapse 44/887 137/7206 6.54847360948e-10 ko04020 Calcium signaling pathway 68/887 265/7206 1.40072247831e-09 ko04720 Long-term potentiation 34/887 99/7206 8.71229891283e-09 ko04970 Salivary secretion 33/887 95/7206 1.04380448874e-08 ko04360 Axon guidance 58/887 233/7206 7.48112063215e-08 ko03040 Spliceosome 1/887 145/7206 1.43558464334e-07 ko04744 Phototransduction 17/887 36/7206 2.57532702981e-07 ko05030 Cocaine addiction 25/887 73/7206 8.7219846502e-07 ko04966 Collecting duct acid secretion 13/887 26/7206 3.04014797802e-06 ko04514 Cell adhesion molecules (CAMs) 35/887 130/7206 4.76484644493e-06 ko04971 Gastric acid secretion 29/887 98/7206 5.97502242927e-06 ko04022 cGMP-PKG signaling pathway 50/887 216/7206 7.10068003246e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 23/887 74/7206 1.51117861966e-05 ko04925 Aldosterone synthesis and secretion 29/887 105/7206 1.70216914056e-05 ko04745 Phototransduction - fly 15/887 38/7206 1.98682379965e-05 ko05203 Viral carcinogenesis 13/887 277/7206 2.17993399579e-05 ko05168 Herpes simplex infection 6/887 182/7206 2.95937519522e-05 ko04120 Ubiquitin mediated proteolysis 3/887 138/7206 3.37106589287e-05 ko03013 RNA transport 5/887 166/7206 3.62600261492e-05 ko04010 MAPK signaling pathway 65/887 321/7206 3.74047159658e-05 ko04730 Long-term depression 23/887 78/7206 3.89046447674e-05 ko04060 Cytokine-cytokine receptor interaction 7/887 191/7206 4.64819319522e-05 ko04972 Pancreatic secretion 29/887 111/7206 5.70329296844e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/887 14/7206 7.74564316954e-05 ko04626 Plant-pathogen interaction 9/887 18/7206 0.000107409575495 ko05164 Influenza A 6/887 167/7206 0.000117409961276 ko05322 Systemic lupus erythematosus 5/887 151/7206 0.000148312543984 ko04742 Taste transduction 18/887 61/7206 0.000262756834635 ko04621 NOD-like receptor signaling pathway 6/887 157/7206 0.000323439218744 ko04141 Protein processing in endoplasmic reticulum 8/887 184/7206 0.000359705174534 ko04964 Proximal tubule bicarbonate reclamation 11/887 29/7206 0.000388805884845 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/887 79/7206 0.000442745691982 ko04915 Estrogen signaling pathway 30/887 131/7206 0.00064943792018 ko04924 Renin secretion 22/887 86/7206 0.000695969627099 ko04610 Complement and coagulation cascades 1/887 79/7206 0.000771901033941 ko03008 Ribosome biogenesis in eukaryotes 1/887 79/7206 0.000771901033941 ko04740 Olfactory transduction 21/887 80/7206 0.000814574724632 ko05110 Vibrio cholerae infection 17/887 63/7206 0.0014386333173 ko04260 Cardiac muscle contraction 23/887 98/7206 0.00173941971104 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/887 59/7206 0.0019735763542 ko04014 Ras signaling pathway 52/887 279/7206 0.00202484306267 ko04540 Gap junction 28/887 128/7206 0.00244136919566 ko04064 NF-kappa B signaling pathway 3/887 96/7206 0.00268315238773 ko04110 Cell cycle 7/887 145/7206 0.00314944463208 ko04640 Hematopoietic cell lineage 1/887 64/7206 0.00360621075477 ko04612 Antigen processing and presentation 2/887 77/7206 0.00471960794191 ko04146 Peroxisome 3/887 89/7206 0.00542643905213 ko04070 Phosphatidylinositol signaling system 24/887 112/7206 0.00548472544475 ko00561 Glycerolipid metabolism 1/887 63/7206 0.00567443041816 ko05169 Epstein-Barr virus infection 13/887 206/7206 0.00676004142973 ko05140 Leishmaniasis 2/887 75/7206 0.00697452643217 ko05120 Epithelial cell signaling in Helicobacter pylori infection 20/887 92/7206 0.00973351673464 ko05205 Proteoglycans in cancer 20/887 271/7206 0.0106271577136 ko05162 Measles 6/887 120/7206 0.0110202605889 ko04750 Inflammatory mediator regulation of TRP channels 25/887 122/7206 0.011409736093 ko00280 Valine, leucine and isoleucine degradation 1/887 54/7206 0.0116704617005 ko00480 Glutathione metabolism 1/887 55/7206 0.0118119927523 ko05321 Inflammatory bowel disease (IBD) 1/887 56/7206 0.0121714639752 ko05414 Dilated cardiomyopathy 23/887 112/7206 0.0127453596881 ko05161 Hepatitis B 11/887 173/7206 0.0134821999764 ko00590 Arachidonic acid metabolism 1/887 52/7206 0.0175455148809 ko05166 HTLV-I infection 23/887 292/7206 0.0177306359816 ko00512 Mucin type O-glycan biosynthesis 8/887 29/7206 0.0205271919908 ko04630 Jak-STAT signaling pathway 8/887 132/7206 0.0229923467501 ko05214 Glioma 17/887 79/7206 0.02300797929 ko04976 Bile secretion 17/887 80/7206 0.0240190910904 ko04114 Oocyte meiosis 26/887 139/7206 0.0260991127396 ko04371 Apelin signaling pathway 32/887 177/7206 0.0267883603702 ko04072 Phospholipase D signaling pathway 35/887 197/7206 0.0270189710528 ko00240 Pyrimidine metabolism 6/887 110/7206 0.0270210240147 ko04960 Aldosterone-regulated sodium reabsorption 10/887 41/7206 0.0284822897878 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/887 15/7206 0.0291222731531 ko00330 Arginine and proline metabolism 2/887 61/7206 0.0291912055282 ko04214 Apoptosis - fly 3/887 72/7206 0.0299061096798 ko00310 Lysine degradation 3/887 73/7206 0.0300976987969 ko04973 Carbohydrate digestion and absorption 10/887 42/7206 0.0320644898754 ko04270 Vascular smooth muscle contraction 28/887 154/7206 0.033939831287 ko04923 Regulation of lipolysis in adipocytes 16/887 77/7206 0.0340699528433 ko04391 Hippo signaling pathway - fly 18/887 90/7206 0.0343107843439 ko04930 Type II diabetes mellitus 12/887 54/7206 0.035563971991 ko03022 Basal transcription factors 1/887 44/7206 0.0371841140547 ko05144 Malaria 1/887 45/7206 0.0376158915551 ko00071 Fatty acid degradation 1/887 45/7206 0.0376158915551 ko05010 Alzheimer's disease 35/887 202/7206 0.0380819702899 ko03420 Nucleotide excision repair 1/887 46/7206 0.0386447667819 ko05410 Hypertrophic cardiomyopathy (HCM) 19/887 100/7206 0.0461299438257