ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 135/790 423/7206 1.01103158395e-33 ko05033 Nicotine addiction 39/790 56/7206 2.41604314079e-25 ko04724 Glutamatergic synapse 65/790 152/7206 2.64700705641e-24 ko04721 Synaptic vesicle cycle 44/790 80/7206 2.89825271688e-22 ko05032 Morphine addiction 46/790 110/7206 4.86642560893e-17 ko04727 GABAergic synapse 45/790 110/7206 2.95800115618e-16 ko04728 Dopaminergic synapse 60/790 185/7206 1.37241959622e-15 ko04723 Retrograde endocannabinoid signaling 56/790 175/7206 2.44109457388e-14 ko04713 Circadian entrainment 45/790 136/7206 2.51096524854e-12 ko04725 Cholinergic synapse 48/790 160/7206 2.53099132964e-11 ko04726 Serotonergic synapse 42/790 137/7206 2.15736922613e-10 ko04024 cAMP signaling pathway 64/790 279/7206 6.19970902737e-09 ko04742 Taste transduction 24/790 61/7206 7.28478587988e-09 ko05014 Amyotrophic lateral sclerosis (ALS) 25/790 74/7206 1.25427469986e-07 ko04514 Cell adhesion molecules (CAMs) 35/790 130/7206 2.64836444399e-07 ko04911 Insulin secretion 32/790 117/7206 5.87438278725e-07 ko03040 Spliceosome 1/790 145/7206 1.30825285671e-06 ko05030 Cocaine addiction 23/790 73/7206 1.62117844022e-06 ko05203 Viral carcinogenesis 9/790 277/7206 2.94724016059e-06 ko04360 Axon guidance 49/790 233/7206 5.31167210195e-06 ko04060 Cytokine-cytokine receptor interaction 4/790 191/7206 5.33576808312e-06 ko05031 Amphetamine addiction 25/790 91/7206 9.21122911585e-06 ko04261 Adrenergic signaling in cardiomyocytes 44/790 205/7206 1.10377548413e-05 ko04744 Phototransduction 14/790 36/7206 1.21374885323e-05 ko04010 MAPK signaling pathway 61/790 321/7206 1.38697857303e-05 ko04966 Collecting duct acid secretion 11/790 26/7206 4.19517496963e-05 ko05168 Herpes simplex infection 5/790 182/7206 5.71982100252e-05 ko04720 Long-term potentiation 24/790 99/7206 0.000135129669655 ko04120 Ubiquitin mediated proteolysis 3/790 138/7206 0.000161388430126 ko04921 Oxytocin signaling pathway 41/790 209/7206 0.000175648550327 ko03013 RNA transport 5/790 166/7206 0.000229135199019 ko05164 Influenza A 5/790 167/7206 0.000229902811386 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/790 14/7206 0.000317886229103 ko04730 Long-term depression 19/790 78/7206 0.000693640412772 ko04260 Cardiac muscle contraction 22/790 98/7206 0.000885469865387 ko05169 Epstein-Barr virus infection 9/790 206/7206 0.000957066776873 ko05205 Proteoglycans in cancer 14/790 271/7206 0.000998613092086 ko04020 Calcium signaling pathway 46/790 265/7206 0.001286725575 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/790 59/7206 0.00135291624921 ko04970 Salivary secretion 21/790 95/7206 0.00139714647182 ko05110 Vibrio cholerae infection 16/790 63/7206 0.00160117819768 ko03008 Ribosome biogenesis in eukaryotes 1/790 79/7206 0.00175793001413 ko05120 Epithelial cell signaling in Helicobacter pylori infection 20/790 92/7206 0.00219967559065 ko04014 Ras signaling pathway 47/790 279/7206 0.0023321687573 ko00240 Pyrimidine metabolism 3/790 110/7206 0.0029556916108 ko04214 Apoptosis - fly 1/790 72/7206 0.00384598663731 ko00310 Lysine degradation 1/790 73/7206 0.00390484284241 ko05162 Measles 4/790 120/7206 0.00452237987376 ko04972 Pancreatic secretion 22/790 111/7206 0.0052555539692 ko04146 Peroxisome 2/790 89/7206 0.00530299527778 ko04141 Protein processing in endoplasmic reticulum 9/790 184/7206 0.00559195668381 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/790 79/7206 0.00564402472007 ko04621 NOD-like receptor signaling pathway 7/790 157/7206 0.00618221436748 ko01200 Carbon metabolism 5/790 128/7206 0.00630412355928 ko03018 RNA degradation 2/790 84/7206 0.00734590471772 ko05322 Systemic lupus erythematosus 7/790 151/7206 0.00820808097521 ko00564 Glycerophospholipid metabolism 3/790 99/7206 0.00843777411465 ko04964 Proximal tubule bicarbonate reclamation 8/790 29/7206 0.0106057265834 ko00330 Arginine and proline metabolism 1/790 61/7206 0.0122940306616 ko04540 Gap junction 23/790 128/7206 0.0147938856384 ko04145 Phagosome 28/790 162/7206 0.0148063871854 ko04110 Cell cycle 7/790 145/7206 0.0148291018131 ko04612 Antigen processing and presentation 2/790 77/7206 0.0152661121253 ko04932 Non-alcoholic fatty liver disease (NAFLD) 10/790 182/7206 0.0155380068128 ko05146 Amoebiasis 4/790 99/7206 0.0224525596542 ko04915 Estrogen signaling pathway 23/790 131/7206 0.0226388963514 ko05161 Hepatitis B 10/790 173/7206 0.0259078139463 ko04022 cGMP-PKG signaling pathway 34/790 216/7206 0.0267906355657 ko00480 Glutathione metabolism 1/790 55/7206 0.027131528426 ko04064 NF-kappa B signaling pathway 4/790 96/7206 0.0309588876506 ko04138 Autophagy - yeast 3/790 81/7206 0.0310656127438 ko04971 Gastric acid secretion 18/790 98/7206 0.0321006849372 ko05166 HTLV-I infection 21/790 292/7206 0.035040534048 ko04072 Phospholipase D signaling pathway 31/790 197/7206 0.0366754039317 ko00380 Tryptophan metabolism 1/790 50/7206 0.0387214413879 ko05323 Rheumatoid arthritis 16/790 89/7206 0.0399450448101 ko00590 Arachidonic acid metabolism 1/790 52/7206 0.040518206868 ko04640 Hematopoietic cell lineage 2/790 64/7206 0.0426534757557 ko05034 Alcoholism 36/790 238/7206 0.0442796218044