ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 79/777 152/7206 1.83994673702e-37 ko04080 Neuroactive ligand-receptor interaction 137/777 423/7206 7.51219167622e-36 ko05033 Nicotine addiction 46/777 56/7206 1.1801950161e-35 ko04727 GABAergic synapse 59/777 110/7206 4.08356950475e-29 ko05032 Morphine addiction 57/777 110/7206 4.01666363737e-27 ko04723 Retrograde endocannabinoid signaling 69/777 175/7206 1.09602733598e-23 ko04713 Circadian entrainment 57/777 136/7206 2.88785155814e-21 ko04728 Dopaminergic synapse 67/777 185/7206 1.30238562622e-20 ko04721 Synaptic vesicle cycle 42/777 80/7206 1.51324249557e-20 ko04744 Phototransduction 27/777 36/7206 1.84129248676e-19 ko04725 Cholinergic synapse 54/777 160/7206 2.80743866722e-15 ko04024 cAMP signaling pathway 73/777 279/7206 1.43295850513e-13 ko04742 Taste transduction 28/777 61/7206 3.0645723882e-12 ko04726 Serotonergic synapse 44/777 137/7206 7.8884874821e-12 ko04911 Insulin secretion 39/777 117/7206 3.49224348432e-11 ko04921 Oxytocin signaling pathway 55/777 209/7206 1.59553458558e-10 ko05031 Amphetamine addiction 32/777 91/7206 4.40428621666e-10 ko04720 Long-term potentiation 33/777 99/7206 1.15944558638e-09 ko04740 Olfactory transduction 29/777 80/7206 1.28756417614e-09 ko05030 Cocaine addiction 27/777 73/7206 2.87881119199e-09 ko04261 Adrenergic signaling in cardiomyocytes 51/777 205/7206 6.45195844266e-09 ko04020 Calcium signaling pathway 60/777 265/7206 1.3126843579e-08 ko05203 Viral carcinogenesis 7/777 277/7206 2.85710041939e-07 ko04970 Salivary secretion 28/777 95/7206 4.03745791828e-07 ko05164 Influenza A 2/777 167/7206 1.68861106635e-06 ko03040 Spliceosome 1/777 145/7206 2.05528207503e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 22/777 74/7206 6.03499318292e-06 ko04060 Cytokine-cytokine receptor interaction 4/777 191/7206 7.95676619735e-06 ko05169 Epstein-Barr virus infection 6/777 206/7206 3.32697562783e-05 ko04925 Aldosterone synthesis and secretion 26/777 105/7206 3.96101016831e-05 ko04260 Cardiac muscle contraction 25/777 98/7206 4.07003010525e-05 ko04010 MAPK signaling pathway 58/777 321/7206 6.40870699533e-05 ko04745 Phototransduction - fly 13/777 38/7206 9.99010202466e-05 ko04972 Pancreatic secretion 26/777 111/7206 0.000135017413109 ko04730 Long-term depression 20/777 78/7206 0.000160966774565 ko05205 Proteoglycans in cancer 12/777 271/7206 0.000200509893613 ko04971 Gastric acid secretion 23/777 98/7206 0.000239037652217 ko05162 Measles 2/777 120/7206 0.000266773089601 ko04022 cGMP-PKG signaling pathway 41/777 216/7206 0.000305180668 ko05168 Herpes simplex infection 6/777 182/7206 0.000367910634682 ko04621 NOD-like receptor signaling pathway 5/777 157/7206 0.000642369937192 ko04932 Non-alcoholic fatty liver disease (NAFLD) 7/777 182/7206 0.000976044377976 ko04966 Collecting duct acid secretion 9/777 26/7206 0.001077380282 ko04120 Ubiquitin mediated proteolysis 4/777 138/7206 0.00119456708186 ko05322 Systemic lupus erythematosus 5/777 151/7206 0.00126606985815 ko04140 Autophagy - animal 6/777 164/7206 0.0013126178567 ko04072 Phospholipase D signaling pathway 36/777 197/7206 0.00147579828507 ko04514 Cell adhesion molecules (CAMs) 26/777 130/7206 0.00152624977115 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/777 79/7206 0.00163762908627 ko04110 Cell cycle 5/777 145/7206 0.00174444076356 ko05161 Hepatitis B 7/777 173/7206 0.00182485092589 ko05414 Dilated cardiomyopathy 23/777 112/7206 0.00192291638961 ko04141 Protein processing in endoplasmic reticulum 8/777 184/7206 0.00243582101482 ko04964 Proximal tubule bicarbonate reclamation 9/777 29/7206 0.00256712967764 ko04612 Antigen processing and presentation 1/777 77/7206 0.0026282989198 ko04610 Complement and coagulation cascades 1/777 79/7206 0.00275468274746 ko05215 Prostate cancer 3/777 111/7206 0.0029276801386 ko03013 RNA transport 7/777 166/7206 0.00336900149362 ko05166 HTLV-I infection 17/777 292/7206 0.00371731590016 ko04924 Renin secretion 18/777 86/7206 0.00469228590123 ko04070 Phosphatidylinositol signaling system 22/777 112/7206 0.00502485581833 ko04350 TGF-beta signaling pathway 3/777 103/7206 0.0058415123983 ko04540 Gap junction 24/777 128/7206 0.00591297067381 ko04214 Apoptosis - fly 1/777 72/7206 0.00610294766606 ko04630 Jak-STAT signaling pathway 5/777 132/7206 0.00646790960878 ko03018 RNA degradation 2/777 84/7206 0.00725663684061 ko05034 Alcoholism 39/777 238/7206 0.00750179564703 ko04915 Estrogen signaling pathway 24/777 131/7206 0.00958378903398 ko04510 Focal adhesion 14/777 240/7206 0.0106282459101 ko04064 NF-kappa B signaling pathway 3/777 96/7206 0.0117191797678 ko00910 Nitrogen metabolism 6/777 19/7206 0.0121928723476 ko04014 Ras signaling pathway 43/777 279/7206 0.0137498745411 ko01524 Platinum drug resistance 2/777 76/7206 0.0148631015626 ko03008 Ribosome biogenesis in eukaryotes 2/777 79/7206 0.0156877800078 ko00562 Inositol phosphate metabolism 17/777 89/7206 0.0157213590217 ko04668 TNF signaling pathway 5/777 120/7206 0.016426490811 ko04210 Apoptosis 10/777 180/7206 0.020130076808 ko00310 Lysine degradation 2/777 73/7206 0.0213193694408 ko04550 Signaling pathways regulating pluripotency of stem cells 9/777 165/7206 0.02198824903 ko04068 FoxO signaling pathway 9/777 167/7206 0.0221915154635 ko05140 Leishmaniasis 2/777 75/7206 0.0222280233134 ko05222 Small cell lung cancer 3/777 89/7206 0.0232957596774 ko04670 Leukocyte transendothelial migration 8/777 151/7206 0.0239832058837 ko04218 Cellular senescence 10/777 177/7206 0.0262415813724 ko00280 Valine, leucine and isoleucine degradation 1/777 54/7206 0.0265101129693 ko04750 Inflammatory mediator regulation of TRP channels 21/777 122/7206 0.026686400586 ko00480 Glutathione metabolism 1/777 55/7206 0.0267557723834 ko05145 Toxoplasmosis 6/777 126/7206 0.0283334747051 ko04976 Bile secretion 15/777 80/7206 0.0283959214548 ko00240 Pyrimidine metabolism 5/777 110/7206 0.0295973356927 ko04150 mTOR signaling pathway 11/777 184/7206 0.0300776669889 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/777 59/7206 0.0311061279572 ko04137 Mitophagy - animal 3/777 82/7206 0.0312060570632 ko05410 Hypertrophic cardiomyopathy (HCM) 18/777 100/7206 0.0325496025787 ko05418 Fluid shear stress and atherosclerosis 10/777 173/7206 0.0338110360129 ko04978 Mineral absorption 9/777 40/7206 0.0341877878455 ko04371 Apelin signaling pathway 28/777 177/7206 0.036122751195 ko04062 Chemokine signaling pathway 31/777 201/7206 0.037378438024 ko05110 Vibrio cholerae infection 12/777 63/7206 0.0410051571636 ko04640 Hematopoietic cell lineage 2/777 64/7206 0.0426648030349 ko05206 MicroRNAs in cancer 11/777 177/7206 0.0488828284241