ko pathway ratio_in_study ratio_in_pop p_value ko03010 Ribosome 79/592 129/7206 5.375109135e-54 ko04610 Complement and coagulation cascades 36/592 79/7206 4.22268035491e-19 ko00190 Oxidative phosphorylation 43/592 127/7206 1.07344599668e-16 ko05012 Parkinson's disease 46/592 155/7206 2.783107737e-15 ko01200 Carbon metabolism 37/592 128/7206 3.90230602939e-12 ko05010 Alzheimer's disease 48/592 202/7206 6.71621001259e-12 ko05016 Huntington's disease 49/592 215/7206 2.04847480429e-11 ko00260 Glycine, serine and threonine metabolism 21/592 48/7206 3.07677149355e-11 ko04260 Cardiac muscle contraction 28/592 98/7206 2.30190312007e-09 ko00010 Glycolysis / Gluconeogenesis 22/592 74/7206 5.57039784066e-08 ko04950 Maturity onset diabetes of the young 13/592 29/7206 1.35001082952e-07 ko05034 Alcoholism 2/592 238/7206 4.48347534124e-07 ko04360 Axon guidance 2/592 233/7206 6.62689161866e-07 ko01230 Biosynthesis of amino acids 22/592 85/7206 8.12455681604e-07 ko04932 Non-alcoholic fatty liver disease (NAFLD) 35/592 182/7206 1.51099381516e-06 ko04975 Fat digestion and absorption 13/592 35/7206 1.84805345696e-06 ko00680 Methane metabolism 12/592 34/7206 8.5910019194e-06 ko04062 Chemokine signaling pathway 2/592 201/7206 1.03424212062e-05 ko00020 Citrate cycle (TCA cycle) 12/592 35/7206 1.21090619867e-05 ko05410 Hypertrophic cardiomyopathy (HCM) 22/592 100/7206 1.45090060069e-05 ko04144 Endocytosis 9/592 342/7206 1.85004974706e-05 ko05150 Staphylococcus aureus infection 11/592 36/7206 9.38445868976e-05 ko04072 Phospholipase D signaling pathway 3/592 197/7206 9.76605470094e-05 ko04080 Neuroactive ligand-receptor interaction 15/592 423/7206 0.000111100724506 ko04060 Cytokine-cytokine receptor interaction 3/592 191/7206 0.000136987185275 ko00030 Pentose phosphate pathway 10/592 32/7206 0.000158659052973 ko00630 Glyoxylate and dicarboxylate metabolism 11/592 38/7206 0.000161499463657 ko00710 Carbon fixation in photosynthetic organisms 9/592 27/7206 0.000195061725766 ko04977 Vitamin digestion and absorption 8/592 22/7206 0.000224167921766 ko00980 Metabolism of xenobiotics by cytochrome P450 11/592 40/7206 0.000266648615509 ko04630 Jak-STAT signaling pathway 1/592 132/7206 0.000301170809452 ko00250 Alanine, aspartate and glutamate metabolism 10/592 38/7206 0.000740723158388 ko05414 Dilated cardiomyopathy 20/592 112/7206 0.000760139960828 ko04114 Oocyte meiosis 2/592 139/7206 0.000911823819578 ko04728 Dopaminergic synapse 4/592 185/7206 0.000947409991653 ko00620 Pyruvate metabolism 11/592 46/7206 0.000977933946157 ko05203 Viral carcinogenesis 9/592 277/7206 0.001087918745 ko00330 Arginine and proline metabolism 13/592 61/7206 0.00112010940971 ko04978 Mineral absorption 10/592 40/7206 0.00114343494501 ko00270 Cysteine and methionine metabolism 11/592 47/7206 0.00118406859197 ko03320 PPAR signaling pathway 14/592 69/7206 0.00121801156659 ko05161 Hepatitis B 4/592 173/7206 0.00182467089423 ko05200 Pathways in cancer 23/592 492/7206 0.0021087251995 ko04974 Protein digestion and absorption 17/592 96/7206 0.00213831251595 ko04024 cAMP signaling pathway 10/592 279/7206 0.00248407154599 ko04014 Ras signaling pathway 10/592 279/7206 0.00248407154599 ko04390 Hippo signaling pathway 5/592 188/7206 0.00272926089131 ko00071 Fatty acid degradation 10/592 45/7206 0.0029625920332 ko04723 Retrograde endocannabinoid signaling 26/592 175/7206 0.00298761152574 ko04071 Sphingolipid signaling pathway 4/592 162/7206 0.00353975506715 ko04140 Autophagy - animal 4/592 164/7206 0.0035781759689 ko04141 Protein processing in endoplasmic reticulum 5/592 184/7206 0.00381263135148 ko04666 Fc gamma R-mediated phagocytosis 2/592 122/7206 0.00399505470694 ko04720 Long-term potentiation 1/592 99/7206 0.00459085279254 ko04722 Neurotrophin signaling pathway 4/592 160/7206 0.00503783985308 ko04725 Cholinergic synapse 4/592 160/7206 0.00503783985308 ko05166 HTLV-I infection 12/592 292/7206 0.00636302771085 ko04933 AGE-RAGE signaling pathway in diabetic complications 3/592 135/7206 0.00643877204844 ko03015 mRNA surveillance pathway 1/592 93/7206 0.00651650962572 ko04015 Rap1 signaling pathway 11/592 278/7206 0.00705932464665 ko04727 GABAergic synapse 2/592 110/7206 0.00798223239953 ko05220 Chronic myeloid leukemia 1/592 85/7206 0.009235387094 ko05210 Colorectal cancer 1/592 86/7206 0.00924874991341 ko04662 B cell receptor signaling pathway 1/592 88/7206 0.00949340876619 ko05323 Rheumatoid arthritis 1/592 89/7206 0.0097266107924 ko00280 Valine, leucine and isoleucine degradation 10/592 54/7206 0.0113991245159 ko04660 T cell receptor signaling pathway 3/592 124/7206 0.0125141929845 ko04512 ECM-receptor interaction 13/592 79/7206 0.0126236382512 ko04310 Wnt signaling pathway 6/592 181/7206 0.0127138181479 ko00480 Glutathione metabolism 10/592 55/7206 0.0129409915018 ko05204 Chemical carcinogenesis 9/592 48/7206 0.0147920515731 ko05167 Kaposi's sarcoma-associated herpesvirus infection 7/592 191/7206 0.0158744201648 ko00040 Pentose and glucuronate interconversions 6/592 26/7206 0.0166521420151 ko04520 Adherens junction 2/592 103/7206 0.0167720528795 ko05206 MicroRNAs in cancer 6/592 177/7206 0.0172778242509 ko04713 Circadian entrainment 4/592 136/7206 0.0177020691449 ko00640 Propanoate metabolism 7/592 34/7206 0.0185587505766 ko04976 Bile secretion 13/592 80/7206 0.0210919709263 ko00500 Starch and sucrose metabolism 7/592 35/7206 0.021608338652 ko05164 Influenza A 6/592 167/7206 0.0223730340817 ko00770 Pantothenate and CoA biosynthesis 4/592 14/7206 0.0232021728399 ko04142 Lysosome 5/592 151/7206 0.0236048024864 ko05132 Salmonella infection 2/592 98/7206 0.0237330084084 ko04380 Osteoclast differentiation 4/592 134/7206 0.0245815443997 ko05231 Choline metabolism in cancer 4/592 134/7206 0.0245815443997 ko04216 Ferroptosis 8/592 44/7206 0.0249886932262 ko04210 Apoptosis 7/592 180/7206 0.0276685107845 ko04964 Proximal tubule bicarbonate reclamation 6/592 29/7206 0.0278776326387 ko00982 Drug metabolism - cytochrome P450 7/592 37/7206 0.0287140074532 ko05030 Cocaine addiction 1/592 73/7206 0.0291081575267 ko05014 Amyotrophic lateral sclerosis (ALS) 1/592 74/7206 0.0297103603408 ko04391 Hippo signaling pathway - fly 2/592 90/7206 0.0322840710674 ko04540 Gap junction 4/592 128/7206 0.0331482357585 ko04070 Phosphatidylinositol signaling system 3/592 112/7206 0.0347369478175 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/592 79/7206 0.0357274938695 ko01220 Degradation of aromatic compounds 2/592 4/7206 0.0361528492426 ko04217 Necroptosis 7/592 178/7206 0.0367316647476 ko04621 NOD-like receptor signaling pathway 6/592 157/7206 0.0393160179171 ko00220 Arginine biosynthesis 5/592 24/7206 0.0422623676265 ko05162 Measles 4/592 120/7206 0.0445345473297 ko00720 Carbon fixation pathways in prokaryotes 4/592 17/7206 0.0453621262552 ko00360 Phenylalanine metabolism 4/592 17/7206 0.0453621262552 ko01522 Endocrine resistance 4/592 124/7206 0.0453959770337 ko04657 IL-17 signaling pathway 2/592 87/7206 0.0463048225823 ko04922 Glucagon signaling pathway 17/592 128/7206 0.0487769533373 ko00350 Tyrosine metabolism 6/592 33/7206 0.0492958555258 ko00340 Histidine metabolism 5/592 25/7206 0.0493935875306