ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1373	423/7206	1.1821300484e-47
ko04724	Glutamatergic synapse	92/1373	152/7206	4.25598648282e-30
ko05032	Morphine addiction	72/1373	110/7206	8.06613439199e-27
ko05033	Nicotine addiction	47/1373	56/7206	9.45035855863e-26
ko04727	GABAergic synapse	69/1373	110/7206	4.03557698521e-24
ko04713	Circadian entrainment	78/1373	136/7206	1.56465090112e-23
ko04725	Cholinergic synapse	81/1373	160/7206	9.67707333951e-20
ko04728	Dopaminergic synapse	89/1373	185/7206	1.12346154112e-19
ko04020	Calcium signaling pathway	110/1373	265/7206	8.08125412841e-18
ko04721	Synaptic vesicle cycle	50/1373	80/7206	1.05006010701e-17
ko04024	cAMP signaling pathway	113/1373	279/7206	3.07999522133e-17
ko04723	Retrograde endocannabinoid signaling	81/1373	175/7206	1.47520073424e-16
ko04742	Taste transduction	38/1373	61/7206	1.07641418292e-13
ko04911	Insulin secretion	57/1373	117/7206	2.53430755962e-13
ko04726	Serotonergic synapse	63/1373	137/7206	5.88206725661e-13
ko04921	Oxytocin signaling pathway	83/1373	209/7206	2.43610763087e-12
ko04744	Phototransduction	26/1373	36/7206	5.4469274087e-12
ko05031	Amphetamine addiction	45/1373	91/7206	4.51033231686e-11
ko03010	Ribosome	1/1373	129/7206	7.40547050717e-11
ko03040	Spliceosome	3/1373	145/7206	5.74443472991e-10
ko04970	Salivary secretion	44/1373	95/7206	1.09001106228e-09
ko04261	Adrenergic signaling in cardiomyocytes	76/1373	205/7206	1.09061193906e-09
ko04022	cGMP-PKG signaling pathway	77/1373	216/7206	5.64587884641e-09
ko04720	Long-term potentiation	44/1373	99/7206	6.09881489922e-09
ko05322	Systemic lupus erythematosus	5/1373	151/7206	1.14965134968e-08
ko03013	RNA transport	8/1373	166/7206	1.13790163334e-07
ko04971	Gastric acid secretion	41/1373	98/7206	1.63829300098e-07
ko04925	Aldosterone synthesis and secretion	43/1373	105/7206	2.12896904596e-07
ko04966	Collecting duct acid secretion	17/1373	26/7206	2.8478166921e-07
ko05030	Cocaine addiction	33/1373	73/7206	4.54209318122e-07
ko04070	Phosphatidylinositol signaling system	44/1373	112/7206	5.84923528723e-07
ko05203	Viral carcinogenesis	25/1373	277/7206	3.54520943826e-06
ko04014	Ras signaling pathway	83/1373	279/7206	1.1425898235e-05
ko04072	Phospholipase D signaling pathway	63/1373	197/7206	1.21352043419e-05
ko04110	Cell cycle	9/1373	145/7206	1.44006824556e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1373	79/7206	1.744130698e-05
ko04360	Axon guidance	71/1373	233/7206	1.93952704297e-05
ko05168	Herpes simplex infection	14/1373	182/7206	2.12400458881e-05
ko04010	MAPK signaling pathway	91/1373	321/7206	4.17574397118e-05
ko04371	Apelin signaling pathway	56/1373	177/7206	5.8340783887e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1373	74/7206	6.73345774202e-05
ko04141	Protein processing in endoplasmic reticulum	16/1373	184/7206	0.000124581838911
ko04972	Pancreatic secretion	38/1373	111/7206	0.000129501896007
ko04740	Olfactory transduction	30/1373	80/7206	0.000135782036331
ko04710	Circadian rhythm	19/1373	43/7206	0.000136956767887
ko04621	NOD-like receptor signaling pathway	13/1373	157/7206	0.000198329698358
ko00520	Amino sugar and nucleotide sugar metabolism	1/1373	55/7206	0.00019922543795
ko04540	Gap junction	42/1373	128/7206	0.00022919870439
ko04924	Renin secretion	31/1373	86/7206	0.000244118957927
ko04745	Phototransduction - fly	17/1373	38/7206	0.000255337967076
ko04750	Inflammatory mediator regulation of TRP channels	40/1373	122/7206	0.000265255089821
ko04514	Cell adhesion molecules (CAMs)	42/1373	130/7206	0.000267364182083
ko04915	Estrogen signaling pathway	42/1373	131/7206	0.000297842490438
ko04922	Glucagon signaling pathway	41/1373	128/7206	0.000380914539677
ko04730	Long-term depression	28/1373	78/7206	0.000406973576008
ko05164	Influenza A	15/1373	167/7206	0.000434477920064
ko04976	Bile secretion	28/1373	80/7206	0.000793318551589
ko05110	Vibrio cholerae infection	23/1373	63/7206	0.00103393409591
ko04923	Regulation of lipolysis in adipocytes	27/1373	77/7206	0.00107112810584
ko03420	Nucleotide excision repair	1/1373	46/7206	0.00108621597176
ko04270	Vascular smooth muscle contraction	46/1373	154/7206	0.00118149252076
ko03022	Basal transcription factors	1/1373	44/7206	0.00165734373214
ko05144	Malaria	1/1373	45/7206	0.00172159268886
ko04622	RIG-I-like receptor signaling pathway	3/1373	62/7206	0.0018517678552
ko05133	Pertussis	6/1373	87/7206	0.00223637175748
ko05205	Proteoglycans in cancer	33/1373	271/7206	0.00265119892496
ko04120	Ubiquitin mediated proteolysis	13/1373	138/7206	0.00289082790281
ko00562	Inositol phosphate metabolism	28/1373	89/7206	0.00422052400586
ko05131	Shigellosis	6/1373	82/7206	0.00433577831755
ko04930	Type II diabetes mellitus	19/1373	54/7206	0.00473976025379
ko05169	Epstein-Barr virus infection	24/1373	206/7206	0.00510107992915
ko05231	Choline metabolism in cancer	39/1373	134/7206	0.00515000673574
ko04711	Circadian rhythm - fly	7/1373	13/7206	0.005247986101
ko03410	Base excision repair	1/1373	38/7206	0.00590513884368
ko04214	Apoptosis - fly	5/1373	72/7206	0.00612094383122
ko04217	Necroptosis	20/1373	178/7206	0.00653846938308
ko04964	Proximal tubule bicarbonate reclamation	12/1373	29/7206	0.00669040960757
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1373	59/7206	0.00683194713707
ko05414	Dilated cardiomyopathy	33/1373	112/7206	0.00724548690712
ko05016	Huntington's disease	26/1373	215/7206	0.00792248629355
ko00280	Valine, leucine and isoleucine degradation	3/1373	54/7206	0.00822986254474
ko04612	Antigen processing and presentation	6/1373	77/7206	0.00832649538625
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1373	79/7206	0.00868303282752
ko05162	Measles	12/1373	120/7206	0.00950255211083
ko05161	Hepatitis B	20/1373	173/7206	0.0105028725421
ko04060	Cytokine-cytokine receptor interaction	23/1373	191/7206	0.0114384924804
ko05140	Leishmaniasis	6/1373	75/7206	0.0114796024872
ko05217	Basal cell carcinoma	5/1373	68/7206	0.012083082807
ko04626	Plant-pathogen interaction	8/1373	18/7206	0.0120895797513
ko04064	NF-kappa B signaling pathway	9/1373	96/7206	0.012579248287
ko00860	Porphyrin and chlorophyll metabolism	1/1373	34/7206	0.0137822001106
ko04015	Rap1 signaling pathway	69/1373	278/7206	0.0155528847595
ko04657	IL-17 signaling pathway	8/1373	87/7206	0.0186046312726
ko04113	Meiosis - yeast	6/1373	70/7206	0.0215214189197
ko05145	Toxoplasmosis	14/1373	126/7206	0.0215726858838
ko04640	Hematopoietic cell lineage	5/1373	64/7206	0.0236078832375
ko00965	Betalain biosynthesis	3/1373	4/7206	0.023679845196
ko00480	Glutathione metabolism	4/1373	55/7206	0.0239375289956
ko05416	Viral myocarditis	4/1373	55/7206	0.0239375289956
ko03018	RNA degradation	8/1373	84/7206	0.0245914146997
ko05219	Bladder cancer	3/1373	48/7206	0.0248267022826
ko04960	Aldosterone-regulated sodium reabsorption	14/1373	41/7206	0.0254555958309
ko05130	Pathogenic Escherichia coli infection	7/1373	77/7206	0.0273506955902
ko04932	Non-alcoholic fatty liver disease (NAFLD)	23/1373	182/7206	0.0273850871721
ko04146	Peroxisome	9/1373	89/7206	0.0293560464281
ko05214	Glioma	23/1373	79/7206	0.0296494286233
ko04672	Intestinal immune network for IgA production	2/1373	37/7206	0.0339592139822
ko00071	Fatty acid degradation	3/1373	45/7206	0.0345313514255
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1373	14/7206	0.0351905646977
ko04115	p53 signaling pathway	7/1373	74/7206	0.0361983352954
ko04260	Cardiac muscle contraction	27/1373	98/7206	0.0376449432857
ko04610	Complement and coagulation cascades	8/1373	79/7206	0.0431398131394
ko05230	Central carbon metabolism in cancer	23/1373	81/7206	0.0447999543534
ko03015	mRNA surveillance pathway	10/1373	93/7206	0.0450948940401
ko00040	Pentose and glucuronate interconversions	1/1373	26/7206	0.0456300126502
ko04142	Lysosome	19/1373	151/7206	0.045887323808
ko05202	Transcriptional misregulation in cancer	25/1373	188/7206	0.04752325565
ko05012	Parkinson's disease	20/1373	155/7206	0.0493862223144