ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1285	423/7206	3.33484339199e-45
ko04724	Glutamatergic synapse	94/1285	152/7206	3.11980929454e-34
ko05033	Nicotine addiction	49/1285	56/7206	6.01540465014e-30
ko05032	Morphine addiction	72/1285	110/7206	1.05017198463e-28
ko04713	Circadian entrainment	79/1285	136/7206	2.70399692067e-26
ko04727	GABAergic synapse	68/1285	110/7206	5.40331887275e-25
ko04728	Dopaminergic synapse	88/1285	185/7206	4.70432419673e-21
ko04725	Cholinergic synapse	80/1285	160/7206	6.07832167511e-21
ko04723	Retrograde endocannabinoid signaling	82/1285	175/7206	3.57286966876e-19
ko04020	Calcium signaling pathway	103/1285	265/7206	2.03481187429e-16
ko04024	cAMP signaling pathway	104/1285	279/7206	3.36712833727e-15
ko04726	Serotonergic synapse	64/1285	137/7206	3.89371654159e-15
ko04911	Insulin secretion	56/1285	117/7206	5.79959714661e-14
ko04721	Synaptic vesicle cycle	43/1285	80/7206	3.1493932522e-13
ko04742	Taste transduction	35/1285	61/7206	4.1236065286e-12
ko04744	Phototransduction	25/1285	36/7206	1.23921208261e-11
ko04921	Oxytocin signaling pathway	77/1285	209/7206	3.93526469703e-11
ko05031	Amphetamine addiction	43/1285	91/7206	8.55206937244e-11
ko04720	Long-term potentiation	45/1285	99/7206	1.58132379959e-10
ko03010	Ribosome	1/1285	129/7206	3.42352175664e-10
ko03040	Spliceosome	2/1285	145/7206	3.74671948917e-10
ko05322	Systemic lupus erythematosus	4/1285	151/7206	9.24888731355e-09
ko04261	Adrenergic signaling in cardiomyocytes	70/1285	205/7206	1.41297228891e-08
ko04360	Axon guidance	75/1285	233/7206	7.01542123655e-08
ko04072	Phospholipase D signaling pathway	66/1285	197/7206	7.52548598451e-08
ko05030	Cocaine addiction	32/1285	73/7206	2.02981375465e-07
ko04970	Salivary secretion	38/1285	95/7206	4.2817306094e-07
ko04971	Gastric acid secretion	38/1285	98/7206	7.92511112797e-07
ko03013	RNA transport	8/1285	166/7206	8.89656281463e-07
ko04925	Aldosterone synthesis and secretion	40/1285	105/7206	8.96280290902e-07
ko04010	MAPK signaling pathway	91/1285	321/7206	2.13348251137e-06
ko05203	Viral carcinogenesis	22/1285	277/7206	2.75373671955e-06
ko04972	Pancreatic secretion	40/1285	111/7206	4.01757801781e-06
ko04070	Phosphatidylinositol signaling system	40/1285	112/7206	4.84708093084e-06
ko04022	cGMP-PKG signaling pathway	65/1285	216/7206	7.77006516978e-06
ko04014	Ras signaling pathway	79/1285	279/7206	9.98621617982e-06
ko04710	Circadian rhythm	20/1285	43/7206	1.34649410041e-05
ko04110	Cell cycle	8/1285	145/7206	1.52433141725e-05
ko04730	Long-term depression	30/1285	78/7206	1.622092835e-05
ko04745	Phototransduction - fly	18/1285	38/7206	2.66869610084e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1285	74/7206	4.22497831174e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1285	79/7206	4.46254166011e-05
ko05231	Choline metabolism in cancer	43/1285	134/7206	5.25958865546e-05
ko04711	Circadian rhythm - fly	9/1285	13/7206	6.36914466035e-05
ko04514	Cell adhesion molecules (CAMs)	42/1285	130/7206	6.37880544947e-05
ko04612	Antigen processing and presentation	2/1285	77/7206	6.719586769e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1285	122/7206	0.000171648511654
ko04740	Olfactory transduction	28/1285	80/7206	0.000193075075642
ko04930	Type II diabetes mellitus	21/1285	54/7206	0.000230499893062
ko04540	Gap junction	40/1285	128/7206	0.000248242933683
ko05168	Herpes simplex infection	15/1285	182/7206	0.000263811142042
ko04621	NOD-like receptor signaling pathway	12/1285	157/7206	0.000309183440278
ko00520	Amino sugar and nucleotide sugar metabolism	1/1285	55/7206	0.000532928409179
ko04141	Protein processing in endoplasmic reticulum	16/1285	184/7206	0.000583479507992
ko05016	Huntington's disease	21/1285	215/7206	0.0010738969096
ko04060	Cytokine-cytokine receptor interaction	18/1285	191/7206	0.00146385520822
ko05164	Influenza A	15/1285	167/7206	0.00146541009293
ko04915	Estrogen signaling pathway	38/1285	131/7206	0.00167469609235
ko03022	Basal transcription factors	1/1285	44/7206	0.00271476636757
ko03420	Nucleotide excision repair	1/1285	46/7206	0.00287076917673
ko05169	Epstein-Barr virus infection	21/1285	206/7206	0.00296873334514
ko04960	Aldosterone-regulated sodium reabsorption	15/1285	41/7206	0.00361960446722
ko04064	NF-kappa B signaling pathway	7/1285	96/7206	0.00450088298407
ko04610	Complement and coagulation cascades	5/1285	79/7206	0.00462628224788
ko05162	Measles	10/1285	120/7206	0.00525488855181
ko04912	GnRH signaling pathway	34/1285	122/7206	0.005717648247
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1285	79/7206	0.00700345895615
ko04015	Rap1 signaling pathway	67/1285	278/7206	0.00814637364749
ko05230	Central carbon metabolism in cancer	24/1285	81/7206	0.0081676249454
ko04115	p53 signaling pathway	5/1285	74/7206	0.00902291783342
ko04672	Intestinal immune network for IgA production	1/1285	37/7206	0.00934935899625
ko00630	Glyoxylate and dicarboxylate metabolism	1/1285	38/7206	0.00938924023622
ko03410	Base excision repair	1/1285	38/7206	0.00938924023622
ko04924	Renin secretion	25/1285	86/7206	0.0100218517396
ko04964	Proximal tubule bicarbonate reclamation	11/1285	29/7206	0.0116545926598
ko05416	Viral myocarditis	3/1285	55/7206	0.0124193105499
ko04922	Glucagon signaling pathway	34/1285	128/7206	0.0138074205114
ko04973	Carbohydrate digestion and absorption	14/1285	42/7206	0.0139073847738
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1285	59/7206	0.0158643240862
ko04260	Cardiac muscle contraction	27/1285	98/7206	0.0161061993279
ko04371	Apelin signaling pathway	44/1285	177/7206	0.0167760050877
ko05144	Malaria	2/1285	45/7206	0.0170818768663
ko00071	Fatty acid degradation	2/1285	45/7206	0.0170818768663
ko05414	Dilated cardiomyopathy	30/1285	112/7206	0.0174590141881
ko04113	Meiosis - yeast	5/1285	70/7206	0.0175004942646
ko04976	Bile secretion	23/1285	80/7206	0.0175404328111
ko04142	Lysosome	16/1285	151/7206	0.0177155913583
ko04622	RIG-I-like receptor signaling pathway	4/1285	62/7206	0.0181980304552
ko00280	Valine, leucine and isoleucine degradation	3/1285	54/7206	0.0184731657758
ko04270	Vascular smooth muscle contraction	39/1285	154/7206	0.0187377203643
ko03018	RNA degradation	7/1285	84/7206	0.0209494820737
ko00860	Porphyrin and chlorophyll metabolism	1/1285	34/7206	0.0217863350279
ko05140	Leishmaniasis	6/1285	75/7206	0.0224602087119
ko04923	Regulation of lipolysis in adipocytes	22/1285	77/7206	0.023313216257
ko04146	Peroxisome	8/1285	89/7206	0.0255459337257
ko05214	Glioma	22/1285	79/7206	0.025766173489
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1285	14/7206	0.0260124567583
ko04916	Melanogenesis	36/1285	142/7206	0.0260131342676
ko05202	Transcriptional misregulation in cancer	22/1285	188/7206	0.0260229723313
ko05161	Hepatitis B	20/1285	173/7206	0.0269931421782
ko05131	Shigellosis	7/1285	82/7206	0.0283130914412
ko05166	HTLV-I infection	38/1285	292/7206	0.0286233970949
ko04626	Plant-pathogen interaction	7/1285	18/7206	0.0290032899465
ko05205	Proteoglycans in cancer	35/1285	271/7206	0.0290810934013
ko00310	Lysine degradation	6/1285	73/7206	0.0305080192728
ko05110	Vibrio cholerae infection	18/1285	63/7206	0.0312673860819
ko04666	Fc gamma R-mediated phagocytosis	31/1285	122/7206	0.0316888038324
ko04120	Ubiquitin mediated proteolysis	15/1285	138/7206	0.0322486941181
ko05133	Pertussis	8/1285	87/7206	0.0338808617907
ko05321	Inflammatory bowel disease (IBD)	4/1285	56/7206	0.0346143501939
ko00562	Inositol phosphate metabolism	24/1285	89/7206	0.0351671596848
ko04966	Collecting duct acid secretion	9/1285	26/7206	0.0365916698339
ko04217	Necroptosis	21/1285	178/7206	0.0366925927456
ko04012	ErbB signaling pathway	28/1285	109/7206	0.0424433898085
ko05012	Parkinson's disease	18/1285	155/7206	0.0433075521338
ko04114	Oocyte meiosis	34/1285	139/7206	0.0439027980231