ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 64/547 145/7206 2.49522404773e-34 ko04110 Cell cycle 51/547 145/7206 5.20344036943e-22 ko04111 Cell cycle - yeast 34/547 90/7206 4.0179092202e-16 ko03410 Base excision repair 20/547 38/7206 2.66024085166e-13 ko03030 DNA replication 20/547 38/7206 2.66024085166e-13 ko04080 Neuroactive ligand-receptor interaction 3/547 423/7206 1.791637008e-11 ko04113 Meiosis - yeast 24/547 70/7206 1.04377514343e-10 ko03013 RNA transport 37/547 166/7206 1.40518255016e-09 ko03008 Ribosome biogenesis in eukaryotes 24/547 79/7206 1.76019606206e-09 ko03460 Fanconi anemia pathway 17/547 51/7206 9.33355410066e-08 ko03440 Homologous recombination 15/547 41/7206 1.31584183556e-07 ko03430 Mismatch repair 11/547 22/7206 1.42509986769e-07 ko03015 mRNA surveillance pathway 22/547 93/7206 1.11071021499e-06 ko04330 Notch signaling pathway 17/547 62/7206 2.1223285197e-06 ko04020 Calcium signaling pathway 3/547 265/7206 2.4152737241e-06 ko05322 Systemic lupus erythematosus 28/547 151/7206 7.27800390297e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/547 182/7206 1.30815579484e-05 ko05202 Transcriptional misregulation in cancer 32/547 188/7206 1.56203229379e-05 ko00240 Pyrimidine metabolism 22/547 110/7206 2.0510796539e-05 ko04550 Signaling pathways regulating pluripotency of stem cells 28/547 165/7206 4.2119416852e-05 ko05166 HTLV-I infection 42/547 292/7206 6.01060723915e-05 ko04145 Phagosome 1/547 162/7206 6.36383345916e-05 ko04144 Endocytosis 9/547 342/7206 9.45445021287e-05 ko04921 Oxytocin signaling pathway 3/547 209/7206 9.61104116247e-05 ko04141 Protein processing in endoplasmic reticulum 2/547 184/7206 0.000102155258122 ko03420 Nucleotide excision repair 12/547 46/7206 0.000115117256792 ko04724 Glutamatergic synapse 1/547 152/7206 0.000139930886793 ko04062 Chemokine signaling pathway 3/547 201/7206 0.000202314035488 ko04310 Wnt signaling pathway 28/547 181/7206 0.000280015437174 ko04060 Cytokine-cytokine receptor interaction 3/547 191/7206 0.000419232879898 ko04071 Sphingolipid signaling pathway 2/547 162/7206 0.000450715800815 ko05217 Basal cell carcinoma 14/547 68/7206 0.00047697667088 ko04621 NOD-like receptor signaling pathway 2/547 157/7206 0.000652827639422 ko04514 Cell adhesion molecules (CAMs) 1/547 130/7206 0.000653999207337 ko05034 Alcoholism 33/547 238/7206 0.00065924626908 ko04725 Cholinergic synapse 2/547 160/7206 0.000685946674194 ko04670 Leukocyte transendothelial migration 2/547 151/7206 0.000939266743184 ko05160 Hepatitis C 2/547 153/7206 0.000956088547926 ko04270 Vascular smooth muscle contraction 2/547 154/7206 0.000973772872382 ko05145 Toxoplasmosis 1/547 126/7206 0.000974004783364 ko00310 Lysine degradation 14/547 73/7206 0.00100627675417 ko03018 RNA degradation 15/547 84/7206 0.00144706330084 ko05168 Herpes simplex infection 26/547 182/7206 0.00155556684155 ko05203 Viral carcinogenesis 36/547 277/7206 0.00158313699008 ko04114 Oocyte meiosis 21/547 139/7206 0.00192569954192 ko04611 Platelet activation 3/547 163/7206 0.00237880364756 ko04380 Osteoclast differentiation 2/547 134/7206 0.00279310434263 ko04713 Circadian entrainment 2/547 136/7206 0.00280917067703 ko04727 GABAergic synapse 1/547 110/7206 0.00306218166473 ko05032 Morphine addiction 1/547 110/7206 0.00306218166473 ko05414 Dilated cardiomyopathy 1/547 112/7206 0.00318595635127 ko05224 Breast cancer 24/547 174/7206 0.00354117285197 ko04014 Ras signaling pathway 9/547 279/7206 0.00361574515383 ko04371 Apelin signaling pathway 4/547 177/7206 0.0036444141825 ko04072 Phospholipase D signaling pathway 5/547 197/7206 0.00380597904433 ko04022 cGMP-PKG signaling pathway 6/547 216/7206 0.00383187690629 ko05142 Chagas disease (American trypanosomiasis) 2/547 130/7206 0.00400556688367 ko04915 Estrogen signaling pathway 2/547 131/7206 0.00403716316511 ko04151 PI3K-Akt signaling pathway 16/547 390/7206 0.0056957266157 ko04540 Gap junction 2/547 128/7206 0.00600433022258 ko05132 Salmonella infection 1/547 98/7206 0.00646984187704 ko04650 Natural killer cell mediated cytotoxicity 1/547 97/7206 0.00647435212675 ko05100 Bacterial invasion of epithelial cells 1/547 99/7206 0.00650930957507 ko00564 Glycerophospholipid metabolism 1/547 99/7206 0.00650930957507 ko05146 Amoebiasis 1/547 99/7206 0.00650930957507 ko05410 Hypertrophic cardiomyopathy (HCM) 1/547 100/7206 0.00659327198958 ko04140 Autophagy - animal 4/547 164/7206 0.00694132035956 ko04530 Tight junction 7/547 228/7206 0.00701578937157 ko04261 Adrenergic signaling in cardiomyocytes 6/547 205/7206 0.00703742648133 ko04728 Dopaminergic synapse 5/547 185/7206 0.00709477566801 ko04015 Rap1 signaling pathway 10/547 278/7206 0.00758531067982 ko04024 cAMP signaling pathway 10/547 279/7206 0.00761356041549 ko04668 TNF signaling pathway 2/547 120/7206 0.00820344706746 ko05206 MicroRNAs in cancer 23/547 177/7206 0.00937562050345 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/547 92/7206 0.00943223156424 ko04722 Neurotrophin signaling pathway 4/547 160/7206 0.0096032498469 ko04970 Salivary secretion 1/547 95/7206 0.00965980815735 ko04210 Apoptosis 5/547 180/7206 0.00968474253869 ko04712 Circadian rhythm - plant 3/547 7/7206 0.0120798477974 ko04010 MAPK signaling pathway 13/547 321/7206 0.0126537182288 ko04933 AGE-RAGE signaling pathway in diabetic complications 3/547 135/7206 0.012815843507 ko04972 Pancreatic secretion 2/547 111/7206 0.01693365584 ko04510 Focal adhesion 9/547 240/7206 0.018241507067 ko04139 Mitophagy - yeast 7/547 37/7206 0.019488748433 ko04950 Maturity onset diabetes of the young 6/547 29/7206 0.0196536910197 ko04120 Ubiquitin mediated proteolysis 18/547 138/7206 0.0217291770997 ko04390 Hippo signaling pathway 23/547 188/7206 0.0241063115112 ko04750 Inflammatory mediator regulation of TRP channels 3/547 122/7206 0.0244886839338 ko04660 T cell receptor signaling pathway 3/547 124/7206 0.0246808871445 ko04370 VEGF signaling pathway 1/547 77/7206 0.0289844822659 ko04664 Fc epsilon RI signaling pathway 1/547 77/7206 0.0289844822659 ko04923 Regulation of lipolysis in adipocytes 1/547 77/7206 0.0289844822659 ko04740 Olfactory transduction 1/547 80/7206 0.0301387863477 ko04810 Regulation of actin cytoskeleton 11/547 264/7206 0.0322487980296 ko04911 Insulin secretion 3/547 117/7206 0.0338201061541 ko04340 Hedgehog signaling pathway 9/547 58/7206 0.0395141089954 ko05418 Fluid shear stress and atherosclerosis 6/547 173/7206 0.0402969764697 ko05231 Choline metabolism in cancer 4/547 134/7206 0.0458748301892 ko03022 Basal transcription factors 7/547 44/7206 0.0460231194796 ko04070 Phosphatidylinositol signaling system 3/547 112/7206 0.0465719150939 ko05152 Tuberculosis 7/547 187/7206 0.0485099703161