ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 139/695 423/7206 4.57596598685e-43 ko04724 Glutamatergic synapse 68/695 152/7206 3.02322876707e-30 ko05033 Nicotine addiction 39/695 56/7206 1.82337630074e-27 ko04728 Dopaminergic synapse 61/695 185/7206 5.64484735001e-19 ko04727 GABAergic synapse 45/695 110/7206 1.97152408289e-18 ko04713 Circadian entrainment 50/695 136/7206 5.37084936588e-18 ko04723 Retrograde endocannabinoid signaling 56/695 175/7206 7.894554001e-17 ko05032 Morphine addiction 43/695 110/7206 8.75673472792e-17 ko04726 Serotonergic synapse 46/695 137/7206 6.6174836997e-15 ko04725 Cholinergic synapse 50/695 160/7206 1.12246682921e-14 ko04911 Insulin secretion 41/695 117/7206 3.91243087518e-14 ko04721 Synaptic vesicle cycle 32/695 80/7206 3.92833898412e-13 ko04024 cAMP signaling pathway 67/695 279/7206 8.36283891003e-13 ko04720 Long-term potentiation 34/695 99/7206 1.18916250072e-11 ko05031 Amphetamine addiction 31/695 91/7206 1.23724056181e-10 ko04020 Calcium signaling pathway 60/695 265/7206 1.69653150566e-10 ko04921 Oxytocin signaling pathway 50/695 209/7206 1.10549862466e-09 ko04742 Taste transduction 22/695 61/7206 1.90499261581e-08 ko04261 Adrenergic signaling in cardiomyocytes 46/695 205/7206 4.3960468572e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 24/695 74/7206 4.68617600928e-08 ko04970 Salivary secretion 27/695 95/7206 1.52267211197e-07 ko05030 Cocaine addiction 23/695 73/7206 1.63087810514e-07 ko04971 Gastric acid secretion 26/695 98/7206 1.12422538585e-06 ko04540 Gap junction 30/695 128/7206 2.93162112013e-06 ko04972 Pancreatic secretion 27/695 111/7206 4.33827472561e-06 ko04730 Long-term depression 21/695 78/7206 9.40406685763e-06 ko03040 Spliceosome 1/695 145/7206 1.13583911084e-05 ko04925 Aldosterone synthesis and secretion 25/695 105/7206 1.46164894925e-05 ko04010 MAPK signaling pathway 55/695 321/7206 1.71774993306e-05 ko04120 Ubiquitin mediated proteolysis 1/695 138/7206 2.62694675822e-05 ko04514 Cell adhesion molecules (CAMs) 28/695 130/7206 3.52921166371e-05 ko05164 Influenza A 3/695 167/7206 8.67677670558e-05 ko05162 Measles 1/695 120/7206 0.000122743154897 ko04022 cGMP-PKG signaling pathway 38/695 216/7206 0.00023416834647 ko04360 Axon guidance 40/695 233/7206 0.000261308992756 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/695 59/7206 0.000350207259384 ko04260 Cardiac muscle contraction 21/695 98/7206 0.000386066575055 ko05168 Herpes simplex infection 5/695 182/7206 0.000495697528021 ko04750 Inflammatory mediator regulation of TRP channels 24/695 122/7206 0.000564965562304 ko04745 Phototransduction - fly 11/695 38/7206 0.00065498034187 ko04014 Ras signaling pathway 44/695 279/7206 0.000874336826346 ko05322 Systemic lupus erythematosus 4/695 151/7206 0.00121842442158 ko04072 Phospholipase D signaling pathway 33/695 197/7206 0.00135925546389 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/695 79/7206 0.0014800737268 ko04744 Phototransduction 10/695 36/7206 0.00162407305031 ko05203 Viral carcinogenesis 13/695 277/7206 0.00340705198344 ko03013 RNA transport 6/695 166/7206 0.00485949327393 ko04964 Proximal tubule bicarbonate reclamation 8/695 29/7206 0.00492427942648 ko04626 Plant-pathogen interaction 6/695 18/7206 0.00530436797245 ko04612 Antigen processing and presentation 1/695 77/7206 0.00597927597323 ko03008 Ribosome biogenesis in eukaryotes 1/695 79/7206 0.00612041752468 ko04060 Cytokine-cytokine receptor interaction 8/695 191/7206 0.00614181062172 ko04912 GnRH signaling pathway 21/695 122/7206 0.00783087959252 ko05110 Vibrio cholerae infection 13/695 63/7206 0.00786221055629 ko04918 Thyroid hormone synthesis 16/695 86/7206 0.00895699861251 ko04966 Collecting duct acid secretion 7/695 26/7206 0.009673343449 ko04915 Estrogen signaling pathway 22/695 131/7206 0.010052828716 ko04146 Peroxisome 2/695 89/7206 0.010821538517 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/695 182/7206 0.01083988628 ko04141 Protein processing in endoplasmic reticulum 8/695 184/7206 0.0108735948993 ko04916 Melanogenesis 23/695 142/7206 0.0135245381392 ko04371 Apelin signaling pathway 27/695 177/7206 0.0141128820463 ko05414 Dilated cardiomyopathy 19/695 112/7206 0.0141891770185 ko04070 Phosphatidylinositol signaling system 19/695 112/7206 0.0141891770185 ko04217 Necroptosis 8/695 178/7206 0.0143114673851 ko04960 Aldosterone-regulated sodium reabsorption 9/695 41/7206 0.0143202841543 ko05169 Epstein-Barr virus infection 10/695 206/7206 0.0160218467772 ko04930 Type II diabetes mellitus 11/695 54/7206 0.0166751086959 ko04630 Jak-STAT signaling pathway 5/695 132/7206 0.0167437365377 ko05034 Alcoholism 34/695 238/7206 0.0184958244182 ko04640 Hematopoietic cell lineage 1/695 64/7206 0.0187780107605 ko04110 Cell cycle 6/695 145/7206 0.0218260539579 ko04621 NOD-like receptor signaling pathway 7/695 157/7206 0.0273700130699 ko04071 Sphingolipid signaling pathway 24/695 162/7206 0.0305346053824 ko01524 Platinum drug resistance 2/695 76/7206 0.0310652025582 ko04610 Complement and coagulation cascades 2/695 79/7206 0.0321235185401 ko00240 Pyrimidine metabolism 4/695 110/7206 0.032394691269 ko04740 Olfactory transduction 14/695 80/7206 0.0329454377279 ko04270 Vascular smooth muscle contraction 23/695 154/7206 0.0368007432432 ko04218 Cellular senescence 9/695 177/7206 0.0381489426536 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/695 14/7206 0.0391810497762 ko04114 Oocyte meiosis 21/695 139/7206 0.0403245114894 ko00680 Methane metabolism 7/695 34/7206 0.0403913124215 ko04924 Renin secretion 14/695 86/7206 0.0428757421329 ko04510 Focal adhesion 14/695 240/7206 0.0444702700589 ko05222 Small cell lung cancer 3/695 89/7206 0.0448096877931