ko pathway ratio_in_study ratio_in_pop p_value ko04512 ECM-receptor interaction 22/410 79/7206 2.27048421536e-10 ko04621 NOD-like receptor signaling pathway 29/410 157/7206 1.19575113316e-08 ko04380 Osteoclast differentiation 26/410 134/7206 2.43017232115e-08 ko04060 Cytokine-cytokine receptor interaction 32/410 191/7206 2.43871966646e-08 ko04510 Focal adhesion 35/410 240/7206 1.94890096772e-07 ko05164 Influenza A 27/410 167/7206 6.55963844494e-07 ko04933 AGE-RAGE signaling pathway in diabetic complications 23/410 135/7206 1.77664929139e-06 ko04668 TNF signaling pathway 21/410 120/7206 3.22845668624e-06 ko04974 Protein digestion and absorption 18/410 96/7206 6.00556275511e-06 ko00643 Styrene degradation 4/410 4/7206 1.03358542178e-05 ko05131 Shigellosis 16/410 82/7206 1.16672628852e-05 ko05034 Alcoholism 1/410 238/7206 2.21290759665e-05 ko05133 Pertussis 16/410 87/7206 2.54574317384e-05 ko00281 Geraniol degradation 4/410 5/7206 4.9348609155e-05 ko04623 Cytosolic DNA-sensing pathway 10/410 41/7206 7.25915058804e-05 ko05145 Toxoplasmosis 19/410 126/7206 8.18737020854e-05 ko04622 RIG-I-like receptor signaling pathway 12/410 62/7206 0.000157535807862 ko04660 T cell receptor signaling pathway 18/410 124/7206 0.000205952389686 ko04658 Th1 and Th2 cell differentiation 15/410 96/7206 0.000306452105715 ko04810 Regulation of actin cytoskeleton 30/410 264/7206 0.000329632365805 ko04657 IL-17 signaling pathway 14/410 87/7206 0.000354289755949 ko05132 Salmonella infection 15/410 98/7206 0.000385584286102 ko05162 Measles 17/410 120/7206 0.000412562876233 ko04666 Fc gamma R-mediated phagocytosis 17/410 122/7206 0.000502188023075 ko05160 Hepatitis C 20/410 153/7206 0.000507368851547 ko00120 Primary bile acid biosynthesis 6/410 20/7206 0.000639912097707 ko04723 Retrograde endocannabinoid signaling 1/410 175/7206 0.000722233722558 ko05150 Staphylococcus aureus infection 8/410 36/7206 0.000757273739198 ko05144 Malaria 9/410 45/7206 0.000811750590302 ko04611 Platelet activation 20/410 163/7206 0.000954425135128 ko04080 Neuroactive ligand-receptor interaction 10/410 423/7206 0.00109350153778 ko04662 B cell receptor signaling pathway 13/410 88/7206 0.00130713761258 ko05146 Amoebiasis 14/410 99/7206 0.00133438958842 ko04620 Toll-like receptor signaling pathway 14/410 100/7206 0.0014732080589 ko00350 Tyrosine metabolism 7/410 33/7206 0.00215570978268 ko05161 Hepatitis B 20/410 173/7206 0.002272233043 ko04064 NF-kappa B signaling pathway 13/410 96/7206 0.00290834546092 ko04728 Dopaminergic synapse 2/410 185/7206 0.0031418266154 ko05140 Leishmaniasis 11/410 75/7206 0.00320049009892 ko03040 Spliceosome 1/410 145/7206 0.00325123262817 ko04110 Cell cycle 1/410 145/7206 0.00325123262817 ko00071 Fatty acid degradation 8/410 45/7206 0.0034436481982 ko04630 Jak-STAT signaling pathway 16/410 132/7206 0.00362261257508 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/410 191/7206 0.00367460445582 ko05410 Hypertrophic cardiomyopathy (HCM) 13/410 100/7206 0.00417007808136 ko04672 Intestinal immune network for IgA production 7/410 37/7206 0.004269092565 ko05323 Rheumatoid arthritis 12/410 89/7206 0.0043131377344 ko04114 Oocyte meiosis 1/410 139/7206 0.00476315606526 ko04610 Complement and coagulation cascades 11/410 79/7206 0.00481673642656 ko05168 Herpes simplex infection 20/410 182/7206 0.00492999408826 ko03013 RNA transport 2/410 166/7206 0.00607077172574 ko04670 Leukocyte transendothelial migration 17/410 151/7206 0.00657916332226 ko00380 Tryptophan metabolism 8/410 50/7206 0.00669363106869 ko04713 Circadian entrainment 1/410 136/7206 0.00734036702809 ko00140 Steroid hormone biosynthesis 7/410 41/7206 0.0076665078398 ko05134 Legionellosis 10/410 74/7206 0.00869653765519 ko03010 Ribosome 1/410 129/7206 0.010652859123 ko00627 Aminobenzoate degradation 3/410 9/7206 0.0118724169117 ko00930 Caprolactam degradation 3/410 9/7206 0.0118724169117 ko04724 Glutamatergic synapse 2/410 152/7206 0.0122372649943 ko05321 Inflammatory bowel disease (IBD) 8/410 56/7206 0.0131711515795 ko00360 Phenylalanine metabolism 4/410 17/7206 0.0135979005037 ko05205 Proteoglycans in cancer 25/410 271/7206 0.0154195729105 ko04920 Adipocytokine signaling pathway 11/410 89/7206 0.0169862458813 ko04659 Th17 cell differentiation 12/410 106/7206 0.0187306332141 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/410 92/7206 0.0192317251859 ko04727 GABAergic synapse 1/410 110/7206 0.0210150585909 ko05032 Morphine addiction 1/410 110/7206 0.0210150585909 ko04726 Serotonergic synapse 2/410 137/7206 0.0243109911706 ko04650 Natural killer cell mediated cytotoxicity 11/410 97/7206 0.0245967057032 ko05016 Huntington's disease 5/410 215/7206 0.0247296512528 ko05100 Bacterial invasion of epithelial cells 11/410 99/7206 0.0273421972251 ko04640 Hematopoietic cell lineage 8/410 64/7206 0.0277238130205 ko05418 Fluid shear stress and atherosclerosis 17/410 173/7206 0.0284349668771 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/410 5/7206 0.0287925166654 ko00565 Ether lipid metabolism 6/410 42/7206 0.0301503056406 ko04217 Necroptosis 17/410 178/7206 0.0319767506061 ko00280 Valine, leucine and isoleucine degradation 7/410 54/7206 0.0321733303321 ko04210 Apoptosis 17/410 180/7206 0.0337944170369 ko04540 Gap junction 2/410 128/7206 0.0341090251976 ko05222 Small cell lung cancer 10/410 89/7206 0.0343103523479 ko00760 Nicotinate and nicotinamide metabolism 5/410 34/7206 0.0414608612969 ko00362 Benzoate degradation 2/410 6/7206 0.0415817899513 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9/410 79/7206 0.0440570993466 ko00500 Starch and sucrose metabolism 5/410 35/7206 0.0462028607758