ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 42/941 56/7206 3.05269157225e-26 ko04080 Neuroactive ligand-receptor interaction 136/941 423/7206 4.1854137543e-26 ko04724 Glutamatergic synapse 71/941 152/7206 1.25749005833e-24 ko05032 Morphine addiction 54/941 110/7206 3.09984973738e-20 ko04727 GABAergic synapse 53/941 110/7206 2.06656029414e-19 ko04721 Synaptic vesicle cycle 43/941 80/7206 2.80012077098e-18 ko04728 Dopaminergic synapse 69/941 185/7206 2.36105945676e-17 ko04713 Circadian entrainment 55/941 136/7206 7.5900176949e-16 ko04725 Cholinergic synapse 58/941 160/7206 3.97322426481e-14 ko04723 Retrograde endocannabinoid signaling 61/941 175/7206 6.68663003484e-14 ko04744 Phototransduction 24/941 36/7206 1.21928763448e-13 ko04024 cAMP signaling pathway 79/941 279/7206 5.0458992664e-12 ko04742 Taste transduction 29/941 61/7206 5.18382497722e-11 ko04911 Insulin secretion 42/941 117/7206 2.02261139463e-10 ko05203 Viral carcinogenesis 8/941 277/7206 4.89873852111e-09 ko04726 Serotonergic synapse 43/941 137/7206 1.79899394677e-08 ko04360 Axon guidance 60/941 233/7206 9.96825943522e-08 ko04261 Adrenergic signaling in cardiomyocytes 54/941 205/7206 2.41474954432e-07 ko03040 Spliceosome 2/941 145/7206 5.94573091491e-07 ko05030 Cocaine addiction 26/941 73/7206 7.03307271253e-07 ko04020 Calcium signaling pathway 63/941 265/7206 1.5154577388e-06 ko04970 Salivary secretion 30/941 95/7206 1.90363430813e-06 ko05164 Influenza A 4/941 167/7206 2.04207682136e-06 ko04921 Oxytocin signaling pathway 52/941 209/7206 3.02725572246e-06 ko04514 Cell adhesion molecules (CAMs) 36/941 130/7206 8.18189643077e-06 ko04120 Ubiquitin mediated proteolysis 3/941 138/7206 9.79584433595e-06 ko05031 Amphetamine addiction 28/941 91/7206 1.00294298777e-05 ko03013 RNA transport 5/941 166/7206 1.15060356483e-05 ko05322 Systemic lupus erythematosus 4/941 151/7206 1.32874693676e-05 ko04621 NOD-like receptor signaling pathway 5/941 157/7206 3.42688525015e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 23/941 74/7206 3.96526134129e-05 ko04010 MAPK signaling pathway 68/941 321/7206 4.05343946483e-05 ko05168 Herpes simplex infection 7/941 182/7206 4.57634883522e-05 ko04060 Cytokine-cytokine receptor interaction 8/941 191/7206 4.69859733641e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/941 14/7206 0.000119065131824 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/941 182/7206 0.000126984245304 ko05169 Epstein-Barr virus infection 10/941 206/7206 0.000133401822089 ko05205 Proteoglycans in cancer 16/941 271/7206 0.000146342261883 ko04740 Olfactory transduction 23/941 80/7206 0.000164155133411 ko04730 Long-term depression 22/941 78/7206 0.000300026584933 ko03008 Ribosome biogenesis in eukaryotes 1/941 79/7206 0.000315513085701 ko04141 Protein processing in endoplasmic reticulum 9/941 184/7206 0.000339329649715 ko04720 Long-term potentiation 26/941 99/7206 0.000402744003678 ko04972 Pancreatic secretion 28/941 111/7206 0.000507163680811 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/941 79/7206 0.000537698612328 ko04966 Collecting duct acid secretion 10/941 26/7206 0.00100961445664 ko04976 Bile secretion 21/941 80/7206 0.00125918877231 ko04217 Necroptosis 10/941 178/7206 0.00151073918677 ko05162 Measles 5/941 120/7206 0.00155095981082 ko03018 RNA degradation 2/941 84/7206 0.00155483522858 ko04064 NF-kappa B signaling pathway 3/941 96/7206 0.00188776949243 ko04022 cGMP-PKG signaling pathway 44/941 216/7206 0.00202997224079 ko04260 Cardiac muscle contraction 24/941 98/7206 0.00209978569885 ko04971 Gastric acid secretion 24/941 98/7206 0.00209978569885 ko04964 Proximal tubule bicarbonate reclamation 10/941 29/7206 0.00263652659409 ko05140 Leishmaniasis 2/941 75/7206 0.00314446665567 ko04612 Antigen processing and presentation 2/941 77/7206 0.00321104804843 ko00330 Arginine and proline metabolism 1/941 61/7206 0.0035014774215 ko04146 Peroxisome 3/941 89/7206 0.0037752688916 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 9/941 26/7206 0.00415889260135 ko00240 Pyrimidine metabolism 5/941 110/7206 0.00418689737798 ko04214 Apoptosis - fly 2/941 72/7206 0.00455771038294 ko04014 Ras signaling pathway 53/941 279/7206 0.00474048754214 ko05161 Hepatitis B 11/941 173/7206 0.00587856247084 ko04070 Phosphatidylinositol signaling system 25/941 112/7206 0.00656222001326 ko01200 Carbon metabolism 7/941 128/7206 0.00762150746984 ko00480 Glutathione metabolism 1/941 55/7206 0.00775235057835 ko04974 Protein digestion and absorption 22/941 96/7206 0.00851510618761 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/941 59/7206 0.00989133646682 ko05145 Toxoplasmosis 7/941 126/7206 0.0104758591437 ko00590 Arachidonic acid metabolism 1/941 52/7206 0.0115147448378 ko04110 Cell cycle 9/941 145/7206 0.0120866341049 ko04630 Jak-STAT signaling pathway 8/941 132/7206 0.0128385330335 ko04072 Phospholipase D signaling pathway 38/941 197/7206 0.0131133467585 ko05016 Huntington's disease 16/941 215/7206 0.0131401939554 ko04140 Autophagy - animal 11/941 164/7206 0.0132421874566 ko04640 Hematopoietic cell lineage 2/941 64/7206 0.0139173062113 ko05414 Dilated cardiomyopathy 24/941 112/7206 0.0151339442091 ko01524 Platinum drug resistance 3/941 76/7206 0.0151516515441 ko05133 Pertussis 4/941 87/7206 0.0153113847259 ko04391 Hippo signaling pathway - fly 20/941 90/7206 0.0167211305393 ko00260 Glycine, serine and threonine metabolism 1/941 48/7206 0.0167850869983 ko00380 Tryptophan metabolism 1/941 50/7206 0.0177189280086 ko05166 HTLV-I infection 25/941 292/7206 0.0207097401478 ko04924 Renin secretion 19/941 86/7206 0.0223704617211 ko04218 Cellular senescence 13/941 177/7206 0.0231130400714 ko04540 Gap junction 26/941 128/7206 0.0232500898173 ko03022 Basal transcription factors 1/941 44/7206 0.0247817642384 ko05144 Malaria 1/941 45/7206 0.0247982979028 ko00071 Fatty acid degradation 1/941 45/7206 0.0247982979028 ko00620 Pyruvate metabolism 1/941 46/7206 0.0252947421827 ko03420 Nucleotide excision repair 1/941 46/7206 0.0252947421827 ko00270 Cysteine and methionine metabolism 1/941 47/7206 0.0262745156036 ko04925 Aldosterone synthesis and secretion 22/941 105/7206 0.0270763253358 ko05321 Inflammatory bowel disease (IBD) 2/941 56/7206 0.0282081776416 ko05418 Fluid shear stress and atherosclerosis 13/941 173/7206 0.0292364977735 ko05131 Shigellosis 4/941 82/7206 0.0300362641558 ko04137 Mitophagy - animal 4/941 82/7206 0.0300362641558 ko04210 Apoptosis 14/941 180/7206 0.032787949585 ko00140 Steroid hormone biosynthesis 1/941 41/7206 0.0364338222495 ko00051 Fructose and mannose metabolism 1/941 42/7206 0.0365786817249 ko00983 Drug metabolism - other enzymes 1/941 42/7206 0.0365786817249 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/941 15/7206 0.0366107755239 ko04657 IL-17 signaling pathway 5/941 87/7206 0.0375573444267 ko05110 Vibrio cholerae infection 14/941 63/7206 0.0379303238112 ko04668 TNF signaling pathway 8/941 120/7206 0.0391114265907