ko pathway ratio_in_study ratio_in_pop p_value ko00190 Oxidative phosphorylation 79/392 127/7206 1.37114289558e-69 ko03010 Ribosome 79/392 129/7206 8.45188318905e-69 ko05012 Parkinson's disease 78/392 155/7206 9.04832706875e-59 ko05010 Alzheimer's disease 80/392 202/7206 3.70047696507e-50 ko05016 Huntington's disease 80/392 215/7206 1.09656470077e-47 ko04932 Non-alcoholic fatty liver disease (NAFLD) 65/392 182/7206 2.75341465292e-37 ko01200 Carbon metabolism 43/392 128/7206 1.55629084711e-23 ko04260 Cardiac muscle contraction 38/392 98/7206 1.72450570615e-23 ko00020 Citrate cycle (TCA cycle) 19/392 35/7206 1.12523159445e-15 ko04723 Retrograde endocannabinoid signaling 37/392 175/7206 3.85250990211e-13 ko00010 Glycolysis / Gluconeogenesis 21/392 74/7206 1.73634067494e-10 ko00280 Valine, leucine and isoleucine degradation 17/392 54/7206 1.6700879742e-09 ko00620 Pyruvate metabolism 15/392 46/7206 8.99130447901e-09 ko00640 Propanoate metabolism 12/392 34/7206 1.04634554598e-07 ko00630 Glyoxylate and dicarboxylate metabolism 12/392 38/7206 4.23412408023e-07 ko00710 Carbon fixation in photosynthetic organisms 10/392 27/7206 7.41777236561e-07 ko05200 Pathways in cancer 6/392 492/7206 8.8763289381e-07 ko00071 Fatty acid degradation 12/392 45/7206 3.17662081312e-06 ko01230 Biosynthesis of amino acids 16/392 85/7206 1.06991441409e-05 ko05410 Hypertrophic cardiomyopathy (HCM) 17/392 100/7206 2.32546855266e-05 ko04360 Axon guidance 1/392 233/7206 4.81647889571e-05 ko00930 Caprolactam degradation 5/392 9/7206 4.87938253493e-05 ko01212 Fatty acid metabolism 12/392 60/7206 7.35262013155e-05 ko04080 Neuroactive ligand-receptor interaction 7/392 423/7206 9.08778423551e-05 ko00720 Carbon fixation pathways in prokaryotes 6/392 17/7206 0.000184781399445 ko05203 Viral carcinogenesis 3/392 277/7206 0.000215232153829 ko04015 Rap1 signaling pathway 3/392 278/7206 0.000215920612223 ko04014 Ras signaling pathway 3/392 279/7206 0.000217273400995 ko04062 Chemokine signaling pathway 1/392 201/7206 0.000226406660837 ko00380 Tryptophan metabolism 10/392 50/7206 0.000292837115362 ko04610 Complement and coagulation cascades 13/392 79/7206 0.000296565056698 ko05414 Dilated cardiomyopathy 16/392 112/7206 0.000335054117335 ko00650 Butanoate metabolism 7/392 26/7206 0.000356609683665 ko05152 Tuberculosis 1/392 187/7206 0.000488348546067 ko04390 Hippo signaling pathway 1/392 188/7206 0.000488696342998 ko04060 Cytokine-cytokine receptor interaction 1/392 191/7206 0.000501387957746 ko04310 Wnt signaling pathway 1/392 181/7206 0.000717567653342 ko04728 Dopaminergic synapse 1/392 185/7206 0.000751204340867 ko04144 Endocytosis 6/392 342/7206 0.000847830254971 ko05206 MicroRNAs in cancer 1/392 177/7206 0.00108644813781 ko04550 Signaling pathways regulating pluripotency of stem cells 1/392 165/7206 0.00153553233322 ko00680 Methane metabolism 7/392 34/7206 0.00200065549644 ko04072 Phospholipase D signaling pathway 2/392 197/7206 0.00211162808731 ko04722 Neurotrophin signaling pathway 1/392 160/7206 0.00225815929418 ko04071 Sphingolipid signaling pathway 1/392 162/7206 0.00230680356932 ko04024 cAMP signaling pathway 5/392 279/7206 0.00291311651576 ko05167 Kaposi's sarcoma-associated herpesvirus infection 2/392 191/7206 0.00305660458974 ko04142 Lysosome 1/392 151/7206 0.00327213386908 ko04724 Glutamatergic synapse 1/392 152/7206 0.00328127106349 ko00270 Cysteine and methionine metabolism 8/392 47/7206 0.00345957529953 ko01210 2-Oxocarboxylic acid metabolism 5/392 20/7206 0.00364866979955 ko03040 Spliceosome 1/392 145/7206 0.00478758945877 ko04110 Cell cycle 1/392 145/7206 0.00478758945877 ko00980 Metabolism of xenobiotics by cytochrome P450 7/392 40/7206 0.00523547601378 ko05161 Hepatitis B 2/392 173/7206 0.00610094256297 ko05224 Breast cancer 2/392 174/7206 0.00611829722883 ko00030 Pentose phosphate pathway 6/392 32/7206 0.00676616733157 ko04114 Oocyte meiosis 1/392 139/7206 0.00703608106986 ko04916 Melanogenesis 1/392 142/7206 0.00735731626436 ko04151 PI3K-Akt signaling pathway 10/392 390/7206 0.00784675488559 ko00062 Fatty acid elongation 6/392 33/7206 0.00789972560106 ko05142 Chagas disease (American trypanosomiasis) 1/392 130/7206 0.0100921911516 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 10/392 79/7206 0.010100149085 ko04630 Jak-STAT signaling pathway 1/392 132/7206 0.010250768358 ko00627 Aminobenzoate degradation 3/392 9/7206 0.0104934319659 ko00410 beta-Alanine metabolism 6/392 35/7206 0.0105660808477 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/392 135/7206 0.0107409042258 ko04140 Autophagy - animal 2/392 164/7206 0.0129622341361 ko00260 Glycine, serine and threonine metabolism 7/392 48/7206 0.0142533317105 ko01522 Endocrine resistance 1/392 124/7206 0.0147596831493 ko00250 Alanine, aspartate and glutamate metabolism 6/392 38/7206 0.015675484822 ko01220 Degradation of aromatic compounds 2/392 4/7206 0.0164600930717 ko00310 Lysine degradation 9/392 73/7206 0.016843012773 ko05166 HTLV-I infection 7/392 292/7206 0.0168637577286 ko04964 Proximal tubule bicarbonate reclamation 5/392 29/7206 0.0187044155217 ko05168 Herpes simplex infection 3/392 182/7206 0.018896703631 ko04919 Thyroid hormone signaling pathway 2/392 143/7206 0.0244188653332 ko00281 Geraniol degradation 2/392 5/7206 0.0264524857923 ko04977 Vitamin digestion and absorption 4/392 22/7206 0.0289374699387 ko04659 Th17 cell differentiation 1/392 106/7206 0.0304342289281 ko04012 ErbB signaling pathway 1/392 109/7206 0.0307525423447 ko00240 Pyrimidine metabolism 1/392 110/7206 0.0310354532188 ko04380 Osteoclast differentiation 2/392 134/7206 0.0342622755382 ko04713 Circadian entrainment 2/392 136/7206 0.0343242056497 ko04726 Serotonergic synapse 2/392 137/7206 0.0344699143399 ko04145 Phagosome 3/392 162/7206 0.0352757194612 ko04810 Regulation of actin cytoskeleton 7/392 264/7206 0.0378897481712 ko00362 Benzoate degradation 2/392 6/7206 0.0382665023903 ko00220 Arginine biosynthesis 4/392 24/7206 0.0386142571538 ko00500 Starch and sucrose metabolism 5/392 35/7206 0.0392485771699 ko04620 Toll-like receptor signaling pathway 1/392 100/7206 0.0439076093013 ko01040 Biosynthesis of unsaturated fatty acids 4/392 25/7206 0.0440652919009 ko05204 Chemical carcinogenesis 6/392 48/7206 0.0443575550806 ko04350 TGF-beta signaling pathway 1/392 103/7206 0.0448820920863 ko00330 Arginine and proline metabolism 7/392 61/7206 0.0464529683838 ko04150 mTOR signaling pathway 4/392 184/7206 0.046875107159 ko05202 Transcriptional misregulation in cancer 4/392 188/7206 0.0479421329144 ko04514 Cell adhesion molecules (CAMs) 2/392 130/7206 0.0483735031181 ko04725 Cholinergic synapse 3/392 160/7206 0.0494979637469 ko00040 Pentose and glucuronate interconversions 4/392 26/7206 0.0499249593055