ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	164/1002	423/7206	9.75256658999e-40
ko05033	Nicotine addiction	49/1002	56/7206	3.22504234877e-35
ko04724	Glutamatergic synapse	83/1002	152/7206	5.70756318083e-33
ko04727	GABAergic synapse	64/1002	110/7206	9.46145780688e-28
ko05032	Morphine addiction	63/1002	110/7206	8.48876627044e-27
ko04713	Circadian entrainment	66/1002	136/7206	1.43992528988e-22
ko04728	Dopaminergic synapse	79/1002	185/7206	2.4563242938e-22
ko04723	Retrograde endocannabinoid signaling	74/1002	175/7206	1.1289591639e-20
ko04744	Phototransduction	29/1002	36/7206	3.11484745182e-19
ko04725	Cholinergic synapse	68/1002	160/7206	3.18951075055e-19
ko04721	Synaptic vesicle cycle	42/1002	80/7206	2.28086462906e-16
ko04024	cAMP signaling pathway	88/1002	279/7206	1.47006092186e-14
ko04742	Taste transduction	34/1002	61/7206	1.60754740553e-14
ko04911	Insulin secretion	49/1002	117/7206	7.06608505357e-14
ko04726	Serotonergic synapse	54/1002	137/7206	7.65133274999e-14
ko04020	Calcium signaling pathway	80/1002	265/7206	2.68440829986e-12
ko05031	Amphetamine addiction	39/1002	91/7206	1.10744228964e-11
ko04740	Olfactory transduction	35/1002	80/7206	6.34097568071e-11
ko04921	Oxytocin signaling pathway	65/1002	209/7206	7.85781082733e-11
ko04720	Long-term potentiation	39/1002	99/7206	2.40679924769e-10
ko04261	Adrenergic signaling in cardiomyocytes	62/1002	205/7206	8.90308618197e-10
ko03040	Spliceosome	1/1002	145/7206	1.46387274243e-08
ko05030	Cocaine addiction	29/1002	73/7206	3.95794347124e-08
ko05203	Viral carcinogenesis	12/1002	277/7206	1.84736344352e-07
ko04970	Salivary secretion	33/1002	95/7206	2.09536733548e-07
ko04060	Cytokine-cytokine receptor interaction	6/1002	191/7206	6.91596502668e-07
ko04925	Aldosterone synthesis and secretion	34/1002	105/7206	1.04221963417e-06
ko04745	Phototransduction - fly	17/1002	38/7206	3.83038686728e-06
ko04010	MAPK signaling pathway	74/1002	321/7206	6.74398817451e-06
ko04621	NOD-like receptor signaling pathway	5/1002	157/7206	1.08174048511e-05
ko04971	Gastric acid secretion	30/1002	98/7206	2.05502857735e-05
ko05322	Systemic lupus erythematosus	5/1002	151/7206	2.2404179098e-05
ko04730	Long-term depression	25/1002	78/7206	3.84152056753e-05
ko05168	Herpes simplex infection	8/1002	182/7206	4.58054356677e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	24/1002	74/7206	4.97279336077e-05
ko03013	RNA transport	7/1002	166/7206	5.72901611088e-05
ko05164	Influenza A	7/1002	167/7206	5.81493075992e-05
ko04514	Cell adhesion molecules (CAMs)	35/1002	130/7206	8.9531032053e-05
ko04120	Ubiquitin mediated proteolysis	5/1002	138/7206	9.23997674467e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1002	79/7206	0.000120922480709
ko04110	Cell cycle	6/1002	145/7206	0.00014694001281
ko04260	Cardiac muscle contraction	28/1002	98/7206	0.000161031958001
ko05162	Measles	4/1002	120/7206	0.000161223905121
ko04612	Antigen processing and presentation	1/1002	77/7206	0.000197807955743
ko04972	Pancreatic secretion	30/1002	111/7206	0.000245037852291
ko04022	cGMP-PKG signaling pathway	49/1002	216/7206	0.00041917618687
ko04072	Phospholipase D signaling pathway	45/1002	197/7206	0.000527802379077
ko04141	Protein processing in endoplasmic reticulum	11/1002	184/7206	0.000765032845756
ko04070	Phosphatidylinositol signaling system	29/1002	112/7206	0.000770244816939
ko04064	NF-kappa B signaling pathway	3/1002	96/7206	0.000863264564013
ko04964	Proximal tubule bicarbonate reclamation	11/1002	29/7206	0.00111639271549
ko04610	Complement and coagulation cascades	2/1002	79/7206	0.00148503190919
ko03008	Ribosome biogenesis in eukaryotes	2/1002	79/7206	0.00148503190919
ko04640	Hematopoietic cell lineage	1/1002	64/7206	0.00154387358083
ko04966	Collecting duct acid secretion	10/1002	26/7206	0.00165411918924
ko05166	HTLV-I infection	23/1002	292/7206	0.00177798874246
ko05169	Epstein-Barr virus infection	14/1002	206/7206	0.00200861115265
ko05140	Leishmaniasis	2/1002	75/7206	0.00209005578524
ko05161	Hepatitis B	11/1002	173/7206	0.00246928159338
ko04976	Bile secretion	21/1002	80/7206	0.00299992718872
ko04750	Inflammatory mediator regulation of TRP channels	29/1002	122/7206	0.00329009527125
ko00480	Glutathione metabolism	1/1002	55/7206	0.00508189276556
ko00562	Inositol phosphate metabolism	22/1002	89/7206	0.00524558079785
ko04140	Autophagy - animal	11/1002	164/7206	0.00575989965528
ko04014	Ras signaling pathway	55/1002	279/7206	0.00605658657131
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1002	182/7206	0.00632024192444
ko04540	Gap junction	29/1002	128/7206	0.00640665017001
ko05205	Proteoglycans in cancer	23/1002	271/7206	0.00709626151416
ko04630	Jak-STAT signaling pathway	8/1002	132/7206	0.00711410855633
ko04924	Renin secretion	21/1002	86/7206	0.0074048369029
ko00590	Arachidonic acid metabolism	1/1002	52/7206	0.00754372738449
ko04657	IL-17 signaling pathway	4/1002	87/7206	0.00760030035263
ko05215	Prostate cancer	6/1002	111/7206	0.00786976205181
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1002	14/7206	0.00789048554787
ko05414	Dilated cardiomyopathy	26/1002	112/7206	0.00814566584645
ko04915	Estrogen signaling pathway	29/1002	131/7206	0.0101287002003
ko05219	Bladder cancer	1/1002	48/7206	0.0109810968203
ko04360	Axon guidance	46/1002	233/7206	0.0120281985075
ko04710	Circadian rhythm	12/1002	43/7206	0.0135094262458
ko05016	Huntington's disease	18/1002	215/7206	0.015963448172
ko00071	Fatty acid degradation	1/1002	45/7206	0.0162779060076
ko04930	Type II diabetes mellitus	14/1002	54/7206	0.0164931444898
ko03420	Nucleotide excision repair	1/1002	46/7206	0.0165564018146
ko05034	Alcoholism	46/1002	238/7206	0.0170674462254
ko00240	Pyrimidine metabolism	7/1002	110/7206	0.0178060592308
ko05321	Inflammatory bowel disease (IBD)	2/1002	56/7206	0.0191490637295
ko04146	Peroxisome	5/1002	89/7206	0.0199395464294
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1002	59/7206	0.0208617327007
ko03022	Basal transcription factors	1/1002	44/7206	0.0253973566874
ko04658	Th1 and Th2 cell differentiation	6/1002	96/7206	0.0255158340457
ko05145	Toxoplasmosis	9/1002	126/7206	0.026384166757
ko05410	Hypertrophic cardiomyopathy (HCM)	22/1002	100/7206	0.0275684041829
ko05110	Vibrio cholerae infection	15/1002	63/7206	0.0282373493746
ko04115	p53 signaling pathway	4/1002	74/7206	0.0282398772889
ko04210	Apoptosis	15/1002	180/7206	0.028557045902
ko00520	Amino sugar and nucleotide sugar metabolism	2/1002	55/7206	0.0286036407091
ko04510	Focal adhesion	22/1002	240/7206	0.029009475968
ko04626	Plant-pathogen interaction	6/1002	18/7206	0.029896389943
ko04350	TGF-beta signaling pathway	7/1002	103/7206	0.0315491569531
ko04142	Lysosome	12/1002	151/7206	0.0318384512344
ko04217	Necroptosis	15/1002	178/7206	0.0362613071408
ko05131	Shigellosis	5/1002	82/7206	0.0366842747409
ko03018	RNA degradation	5/1002	84/7206	0.0373654127916
ko04922	Glucagon signaling pathway	26/1002	128/7206	0.0391594415652
ko00310	Lysine degradation	4/1002	73/7206	0.0393302273991
ko00330	Arginine and proline metabolism	3/1002	61/7206	0.0399236966474
ko04622	RIG-I-like receptor signaling pathway	3/1002	62/7206	0.0404016956993
ko05418	Fluid shear stress and atherosclerosis	15/1002	173/7206	0.0448337267955
ko04371	Apelin signaling pathway	34/1002	177/7206	0.0469677730259