ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 58/503 191/7206 4.03612043803e-23 ko04380 Osteoclast differentiation 35/503 134/7206 3.40078960195e-12 ko04650 Natural killer cell mediated cytotoxicity 29/503 97/7206 6.75998611237e-12 ko05321 Inflammatory bowel disease (IBD) 21/503 56/7206 4.71953859349e-11 ko05164 Influenza A 37/503 167/7206 1.55064283996e-10 ko05162 Measles 29/503 120/7206 1.88106526654e-09 ko05340 Primary immunodeficiency 14/503 30/7206 2.80638068028e-09 ko04621 NOD-like receptor signaling pathway 33/503 157/7206 6.50450708639e-09 ko05330 Allograft rejection 12/503 24/7206 1.46719389229e-08 ko05140 Leishmaniasis 21/503 75/7206 2.10005295725e-08 ko05150 Staphylococcus aureus infection 14/503 36/7206 4.95076832713e-08 ko04672 Intestinal immune network for IgA production 14/503 37/7206 7.46109513065e-08 ko04064 NF-kappa B signaling pathway 23/503 96/7206 1.09196608596e-07 ko04217 Necroptosis 33/503 178/7206 1.61088990056e-07 ko05152 Tuberculosis 34/503 187/7206 1.69905483726e-07 ko05320 Autoimmune thyroid disease 12/503 29/7206 2.03652378361e-07 ko05168 Herpes simplex infection 33/503 182/7206 2.77178199267e-07 ko04610 Complement and coagulation cascades 20/503 79/7206 2.84019184045e-07 ko04658 Th1 and Th2 cell differentiation 22/503 96/7206 4.75527796899e-07 ko05323 Rheumatoid arthritis 21/503 89/7206 5.16159744887e-07 ko04659 Th17 cell differentiation 23/503 106/7206 7.38417999168e-07 ko04620 Toll-like receptor signaling pathway 22/503 100/7206 1.00380040905e-06 ko05332 Graft-versus-host disease 9/503 18/7206 1.00907158715e-06 ko04630 Jak-STAT signaling pathway 26/503 132/7206 1.02715463634e-06 ko04640 Hematopoietic cell lineage 17/503 64/7206 1.07558279225e-06 ko05144 Malaria 14/503 45/7206 1.21018672814e-06 ko05145 Toxoplasmosis 25/503 126/7206 1.44113942354e-06 ko00120 Primary bile acid biosynthesis 9/503 20/7206 3.07068856268e-06 ko05310 Asthma 8/503 17/7206 7.38494182451e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 31/503 191/7206 8.1095234473e-06 ko04660 T cell receptor signaling pathway 23/503 124/7206 1.23728459691e-05 ko04612 Antigen processing and presentation 17/503 77/7206 1.63193230239e-05 ko04310 Wnt signaling pathway 1/503 181/7206 4.43787331025e-05 ko03013 RNA transport 1/503 166/7206 0.000146728953959 ko05418 Fluid shear stress and atherosclerosis 26/503 173/7206 0.000194533287113 ko04940 Type I diabetes mellitus 9/503 32/7206 0.000240444453413 ko05034 Alcoholism 4/503 238/7206 0.000247773749849 ko05133 Pertussis 16/503 87/7206 0.000287179683405 ko04723 Retrograde endocannabinoid signaling 2/503 175/7206 0.000463267313647 ko04137 Mitophagy - animal 15/503 82/7206 0.000468821883628 ko04916 Melanogenesis 1/503 142/7206 0.00067724761333 ko03040 Spliceosome 1/503 145/7206 0.000717851074397 ko04145 Phagosome 23/503 162/7206 0.000906209767084 ko04622 RIG-I-like receptor signaling pathway 12/503 62/7206 0.00101508503294 ko05160 Hepatitis C 22/503 153/7206 0.00105615851639 ko05161 Hepatitis B 24/503 173/7206 0.00120029634337 ko03010 Ribosome 1/503 129/7206 0.00144754303946 ko04611 Platelet activation 23/503 163/7206 0.00148443177205 ko04933 AGE-RAGE signaling pathway in diabetic complications 20/503 135/7206 0.00161289631228 ko04668 TNF signaling pathway 18/503 120/7206 0.00171433540024 ko04664 Fc epsilon RI signaling pathway 13/503 77/7206 0.00235585080365 ko05142 Chagas disease (American trypanosomiasis) 19/503 130/7206 0.00241972624168 ko00590 Arachidonic acid metabolism 10/503 52/7206 0.00276184962946 ko04911 Insulin secretion 1/503 117/7206 0.00310428852643 ko04662 B cell receptor signaling pathway 14/503 88/7206 0.00453980400841 ko04728 Dopaminergic synapse 4/503 185/7206 0.00511834105888 ko04390 Hippo signaling pathway 4/503 188/7206 0.00522736682472 ko04670 Leukocyte transendothelial migration 20/503 151/7206 0.00525135704589 ko04713 Circadian entrainment 2/503 136/7206 0.00586126652538 ko04072 Phospholipase D signaling pathway 24/503 197/7206 0.0065925400829 ko04972 Pancreatic secretion 1/503 111/7206 0.0070658222804 ko00051 Fructose and mannose metabolism 8/503 42/7206 0.00761332924884 ko05202 Transcriptional misregulation in cancer 23/503 188/7206 0.00818458203047 ko01200 Carbon metabolism 2/503 128/7206 0.00830873073739 ko05132 Salmonella infection 14/503 98/7206 0.00852603727693 ko05166 HTLV-I infection 32/503 292/7206 0.00957438341445 ko04062 Chemokine signaling pathway 24/503 201/7206 0.0104958698929 ko04210 Apoptosis 22/503 180/7206 0.0106518625505 ko04666 Fc gamma R-mediated phagocytosis 16/503 122/7206 0.011799319189 ko00982 Drug metabolism - cytochrome P450 7/503 37/7206 0.012734299461 ko05416 Viral myocarditis 9/503 55/7206 0.0130190753369 ko04530 Tight junction 7/503 228/7206 0.0165245422976 ko03015 mRNA surveillance pathway 1/503 93/7206 0.0212474821964 ko04623 Cytosolic DNA-sensing pathway 7/503 41/7206 0.0218772000503 ko00950 Isoquinoline alkaloid biosynthesis 3/503 10/7206 0.0280327529686 ko05016 Huntington's disease 7/503 215/7206 0.0285736004742 ko01230 Biosynthesis of amino acids 1/503 85/7206 0.029703048122 ko04910 Insulin signaling pathway 5/503 172/7206 0.0325958340812 ko05224 Breast cancer 5/503 174/7206 0.033131796282 ko05032 Morphine addiction 2/503 110/7206 0.0347930708921 ko00592 alpha-Linolenic acid metabolism 4/503 19/7206 0.039280101168 ko01524 Platinum drug resistance 10/503 76/7206 0.0414586290042 ko04740 Olfactory transduction 1/503 80/7206 0.0433288755735 ko05212 Pancreatic cancer 11/503 83/7206 0.0459696945007 ko04110 Cell cycle 4/503 145/7206 0.0461285834687 ko05204 Chemical carcinogenesis 7/503 48/7206 0.0472478291773 ko05010 Alzheimer's disease 7/503 202/7206 0.0486337840378