ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 25/206 152/7206 7.07992874002e-13 ko04080 Neuroactive ligand-receptor interaction 39/206 423/7206 3.76087756196e-11 ko04020 Calcium signaling pathway 27/206 265/7206 6.51299639285e-09 ko04728 Dopaminergic synapse 21/206 185/7206 5.50687914939e-08 ko05031 Amphetamine addiction 14/206 91/7206 2.40105047149e-07 ko05033 Nicotine addiction 11/206 56/7206 3.84724457279e-07 ko04727 GABAergic synapse 15/206 110/7206 4.47854779504e-07 ko05030 Cocaine addiction 12/206 73/7206 8.58285736527e-07 ko04911 Insulin secretion 15/206 117/7206 1.00789869622e-06 ko04072 Phospholipase D signaling pathway 19/206 197/7206 3.02893745716e-06 ko04720 Long-term potentiation 13/206 99/7206 4.1378469591e-06 ko04723 Retrograde endocannabinoid signaling 17/206 175/7206 9.32559538903e-06 ko04022 cGMP-PKG signaling pathway 19/206 216/7206 1.16909801289e-05 ko04725 Cholinergic synapse 16/206 160/7206 1.19296633667e-05 ko05032 Morphine addiction 13/206 110/7206 1.34458843843e-05 ko04713 Circadian entrainment 14/206 136/7206 3.07126183926e-05 ko04726 Serotonergic synapse 14/206 137/7206 3.33571363584e-05 ko04024 cAMP signaling pathway 21/206 279/7206 4.31660530431e-05 ko04915 Estrogen signaling pathway 13/206 131/7206 8.68450297729e-05 ko04360 Axon guidance 18/206 233/7206 0.000111550690476 ko04261 Adrenergic signaling in cardiomyocytes 16/206 205/7206 0.000240541641556 ko04972 Pancreatic secretion 11/206 111/7206 0.000308941971785 ko05231 Choline metabolism in cancer 12/206 134/7206 0.000425839913707 ko04211 Longevity regulating pathway 11/206 123/7206 0.000746128095554 ko04925 Aldosterone synthesis and secretion 10/206 105/7206 0.000793190277335 ko04921 Oxytocin signaling pathway 15/206 209/7206 0.000909189542377 ko04070 Phosphatidylinositol signaling system 10/206 112/7206 0.00130861499418 ko04970 Salivary secretion 9/206 95/7206 0.00149870034043 ko04923 Regulation of lipolysis in adipocytes 8/206 77/7206 0.00150759210767 ko04371 Apelin signaling pathway 13/206 177/7206 0.0016141468142 ko04742 Taste transduction 7/206 61/7206 0.00165950964669 ko05213 Endometrial cancer 7/206 62/7206 0.00182626706003 ko04015 Rap1 signaling pathway 17/206 278/7206 0.00271647446761 ko04010 MAPK signaling pathway 19/206 321/7206 0.00279866136313 ko04213 Longevity regulating pathway - multiple species 8/206 86/7206 0.00305471734182 ko04540 Gap junction 10/206 128/7206 0.00353397216477 ko04012 ErbB signaling pathway 9/206 109/7206 0.00385874120112 ko05414 Dilated cardiomyopathy 9/206 112/7206 0.00462132926255 ko04062 Chemokine signaling pathway 13/206 201/7206 0.007592477637 ko04912 GnRH signaling pathway 9/206 122/7206 0.00803696137395 ko00512 Mucin type O-glycan biosynthesis 4/206 29/7206 0.00879541948211 ko05034 Alcoholism 14/206 238/7206 0.00900067611031 ko01521 EGFR tyrosine kinase inhibitor resistance 8/206 106/7206 0.0107039600256 ko05223 Non-small cell lung cancer 6/206 66/7206 0.011084973034 ko04924 Renin secretion 7/206 86/7206 0.0112371834258 ko00562 Inositol phosphate metabolism 7/206 89/7206 0.0134177282272 ko00510 N-Glycan biosynthesis 5/206 50/7206 0.0135725496554 ko04139 Mitophagy - yeast 4/206 37/7206 0.0204950380663 ko04971 Gastric acid secretion 7/206 98/7206 0.0217634658359 ko04666 Fc gamma R-mediated phagocytosis 8/206 122/7206 0.0232706096736 ko04730 Long-term depression 6/206 78/7206 0.0236841310574 ko05214 Glioma 6/206 79/7206 0.0250420336441 ko05203 Viral carcinogenesis 2/206 277/7206 0.025309390638 ko01522 Endocrine resistance 8/206 124/7206 0.0253624623367 ko04721 Synaptic vesicle cycle 6/206 80/7206 0.0264510058174 ko04914 Progesterone-mediated oocyte maturation 7/206 104/7206 0.0290027308289 ko00513 Various types of N-glycan biosynthesis 4/206 42/7206 0.0311246039837 ko04973 Carbohydrate digestion and absorption 4/206 42/7206 0.0311246039837 ko00515 Mannose type O-glycan biosynthesis 3/206 25/7206 0.0333386593917 ko04918 Thyroid hormone synthesis 6/206 86/7206 0.0360131793238 ko04917 Prolactin signaling pathway 6/206 87/7206 0.0377968860614 ko04662 B cell receptor signaling pathway 6/206 88/7206 0.0396361886862 ko04270 Vascular smooth muscle contraction 9/206 154/7206 0.0430349308088 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3/206 28/7206 0.044631773644 ko05166 HTLV-I infection 14/206 292/7206 0.0485797481685