ko pathway ratio_in_study ratio_in_pop p_value ko04950 Maturity onset diabetes of the young 13/518 29/7206 2.74863529096e-08 ko04550 Signaling pathways regulating pluripotency of stem cells 32/518 165/7206 1.65875758969e-07 ko05217 Basal cell carcinoma 18/518 68/7206 8.45227848934e-07 ko04721 Synaptic vesicle cycle 19/518 80/7206 2.5219356277e-06 ko05224 Breast cancer 30/518 174/7206 7.24116023924e-06 ko05168 Herpes simplex infection 1/518 182/7206 2.97540994222e-05 ko05033 Nicotine addiction 13/518 56/7206 0.000125915334866 ko05202 Transcriptional misregulation in cancer 28/518 188/7206 0.000248480467077 ko04145 Phagosome 25/518 162/7206 0.000274529057009 ko04727 GABAergic synapse 19/518 110/7206 0.000275723508654 ko04360 Axon guidance 32/518 233/7206 0.000395429780432 ko03040 Spliceosome 1/518 145/7206 0.000467242415301 ko05014 Amyotrophic lateral sclerosis (ALS) 14/518 74/7206 0.000677211688631 ko04340 Hedgehog signaling pathway 12/518 58/7206 0.000704492105167 ko05200 Pathways in cancer 55/518 492/7206 0.000777375928799 ko04728 Dopaminergic synapse 26/518 185/7206 0.000797703559738 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/518 182/7206 0.00119064059618 ko04141 Protein processing in endoplasmic reticulum 3/518 184/7206 0.00121538369162 ko04080 Neuroactive ligand-receptor interaction 48/518 423/7206 0.00128428160048 ko01200 Carbon metabolism 1/518 128/7206 0.00146848892959 ko04390 Hippo signaling pathway 25/518 188/7206 0.00238985841423 ko04060 Cytokine-cytokine receptor interaction 4/518 191/7206 0.00263938887484 ko05203 Viral carcinogenesis 8/518 277/7206 0.00278402582148 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/518 59/7206 0.00281586870072 ko04310 Wnt signaling pathway 24/518 181/7206 0.00315408115716 ko04611 Platelet activation 3/518 163/7206 0.00335122756932 ko04512 ECM-receptor interaction 13/518 79/7206 0.00383847168104 ko04974 Protein digestion and absorption 15/518 96/7206 0.00404179431982 ko04330 Notch signaling pathway 11/518 62/7206 0.00420633834613 ko04151 PI3K-Akt signaling pathway 43/518 390/7206 0.00450999101533 ko04260 Cardiac muscle contraction 15/518 98/7206 0.00467535868215 ko05205 Proteoglycans in cancer 32/518 271/7206 0.00537130703569 ko04911 Insulin secretion 17/518 117/7206 0.00551678958075 ko04621 NOD-like receptor signaling pathway 3/518 157/7206 0.00693123506363 ko04010 MAPK signaling pathway 36/518 321/7206 0.00751652931606 ko05032 Morphine addiction 16/518 110/7206 0.00754846210655 ko04261 Adrenergic signaling in cardiomyocytes 25/518 205/7206 0.00850870129934 ko04514 Cell adhesion molecules (CAMs) 18/518 130/7206 0.00876457591842 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/518 26/7206 0.00893666670427 ko04910 Insulin signaling pathway 4/518 172/7206 0.0100250414767 ko05162 Measles 2/518 120/7206 0.0117351787866 ko04211 Longevity regulating pathway 2/518 123/7206 0.0121124256761 ko03013 RNA transport 4/518 166/7206 0.013717194324 ko04064 NF-kappa B signaling pathway 1/518 96/7206 0.0145973205376 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/518 14/7206 0.0147887210118 ko00430 Taurine and hypotaurine metabolism 4/518 14/7206 0.0147887210118 ko04964 Proximal tubule bicarbonate reclamation 6/518 29/7206 0.0153566710988 ko04723 Retrograde endocannabinoid signaling 21/518 175/7206 0.0173835766785 ko04062 Chemokine signaling pathway 6/518 201/7206 0.0174616520136 ko04120 Ubiquitin mediated proteolysis 3/518 138/7206 0.0182270123035 ko04213 Longevity regulating pathway - multiple species 1/518 86/7206 0.0201749439757 ko05130 Pathogenic Escherichia coli infection 11/518 77/7206 0.0240566704519 ko04612 Antigen processing and presentation 11/518 77/7206 0.0240566704519 ko04138 Autophagy - yeast 1/518 81/7206 0.0292491833488 ko01230 Biosynthesis of amino acids 1/518 85/7206 0.0307837260487 ko05164 Influenza A 5/518 167/7206 0.0324594916563 ko04914 Progesterone-mediated oocyte maturation 2/518 104/7206 0.0333201013483 ko04066 HIF-1 signaling pathway 3/518 123/7206 0.0341017942202 ko04391 Hippo signaling pathway - fly 12/518 90/7206 0.0361628674931 ko04724 Glutamatergic synapse 18/518 152/7206 0.0368145020246 ko05030 Cocaine addiction 10/518 73/7206 0.0391610970475 ko01524 Platinum drug resistance 1/518 76/7206 0.0424106558237 ko04713 Circadian entrainment 16/518 136/7206 0.0437329306798 ko04610 Complement and coagulation cascades 1/518 79/7206 0.0441043850358 ko03008 Ribosome biogenesis in eukaryotes 1/518 79/7206 0.0441043850358 ko00472 D-Arginine and D-ornithine metabolism 2/518 5/7206 0.0445807569267 ko00311 Penicillin and cephalosporin biosynthesis 2/518 5/7206 0.0445807569267