ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 142/926 423/7206 2.65377781201e-30 ko04724 Glutamatergic synapse 73/926 152/7206 1.07850524385e-26 ko05033 Nicotine addiction 42/926 56/7206 1.58160780561e-26 ko04721 Synaptic vesicle cycle 49/926 80/7206 1.89487860134e-24 ko04727 GABAergic synapse 51/926 110/7206 4.06349030231e-18 ko05032 Morphine addiction 51/926 110/7206 4.06349030231e-18 ko04728 Dopaminergic synapse 67/926 185/7206 1.74598619369e-16 ko04713 Circadian entrainment 54/926 136/7206 1.77514816527e-15 ko04725 Cholinergic synapse 59/926 160/7206 4.64731367674e-15 ko04723 Retrograde endocannabinoid signaling 60/926 175/7206 1.21006170285e-13 ko04024 cAMP signaling pathway 75/926 279/7206 1.1918892854e-10 ko04911 Insulin secretion 41/926 117/7206 4.73660512678e-10 ko04742 Taste transduction 27/926 61/7206 1.2470268686e-09 ko04726 Serotonergic synapse 44/926 137/7206 2.60222746319e-09 ko04744 Phototransduction 18/926 36/7206 7.26833961658e-08 ko03040 Spliceosome 1/926 145/7206 9.62339320974e-08 ko05031 Amphetamine addiction 31/926 91/7206 1.33824030199e-07 ko04261 Adrenergic signaling in cardiomyocytes 53/926 205/7206 3.58617205581e-07 ko05030 Cocaine addiction 26/926 73/7206 5.1233287258e-07 ko04720 Long-term potentiation 31/926 99/7206 1.10970026456e-06 ko04360 Axon guidance 57/926 233/7206 1.15966938357e-06 ko04120 Ubiquitin mediated proteolysis 2/926 138/7206 2.03021635153e-06 ko05203 Viral carcinogenesis 12/926 277/7206 2.19759708985e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 25/926 74/7206 2.60294674339e-06 ko05168 Herpes simplex infection 5/926 182/7206 2.73382977842e-06 ko05164 Influenza A 4/926 167/7206 3.08819314446e-06 ko04921 Oxytocin signaling pathway 51/926 209/7206 4.37495084637e-06 ko04966 Collecting duct acid secretion 13/926 26/7206 4.9614956377e-06 ko04970 Salivary secretion 28/926 95/7206 1.52582782118e-05 ko03013 RNA transport 5/926 166/7206 1.70017367251e-05 ko04060 Cytokine-cytokine receptor interaction 7/926 191/7206 2.31132047903e-05 ko04514 Cell adhesion molecules (CAMs) 34/926 130/7206 3.12209813847e-05 ko04621 NOD-like receptor signaling pathway 5/926 157/7206 5.07978765469e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/926 14/7206 0.000105960727154 ko05162 Measles 3/926 120/7206 0.000147235179503 ko05205 Proteoglycans in cancer 16/926 271/7206 0.000196368696927 ko04540 Gap junction 31/926 128/7206 0.000418148804156 ko04141 Protein processing in endoplasmic reticulum 9/926 184/7206 0.000471981895505 ko04020 Calcium signaling pathway 54/926 265/7206 0.000485958591985 ko03008 Ribosome biogenesis in eukaryotes 1/926 79/7206 0.000503154543707 ko04260 Cardiac muscle contraction 25/926 98/7206 0.000630583574827 ko04010 MAPK signaling pathway 62/926 321/7206 0.000817528912684 ko04730 Long-term depression 21/926 78/7206 0.000875504303092 ko04961 Endocrine and other factor-regulated calcium reabsorption 17/926 59/7206 0.00115641707414 ko05322 Systemic lupus erythematosus 7/926 151/7206 0.00122211232085 ko05169 Epstein-Barr virus infection 12/926 206/7206 0.00139330738547 ko04064 NF-kappa B signaling pathway 3/926 96/7206 0.00183580354447 ko04971 Gastric acid secretion 24/926 98/7206 0.00194538442965 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/926 79/7206 0.00210401426933 ko04972 Pancreatic secretion 26/926 111/7206 0.00227461731289 ko04964 Proximal tubule bicarbonate reclamation 10/926 29/7206 0.00233434745178 ko04640 Hematopoietic cell lineage 1/926 64/7206 0.00236590724602 ko04022 cGMP-PKG signaling pathway 43/926 216/7206 0.00267498367218 ko04740 Olfactory transduction 20/926 80/7206 0.00350454975392 ko00330 Arginine and proline metabolism 1/926 61/7206 0.0035129570663 ko04146 Peroxisome 3/926 89/7206 0.00372766178739 ko00310 Lysine degradation 2/926 73/7206 0.00460586453045 ko05140 Leishmaniasis 2/926 75/7206 0.00470114999131 ko04915 Estrogen signaling pathway 28/926 131/7206 0.00539476422423 ko04110 Cell cycle 8/926 145/7206 0.00545219580678 ko05146 Amoebiasis 4/926 99/7206 0.00579703741849 ko00240 Pyrimidine metabolism 5/926 110/7206 0.00586549146189 ko05110 Vibrio cholerae infection 16/926 63/7206 0.00670380128268 ko05034 Alcoholism 45/926 238/7206 0.00747830530892 ko05321 Inflammatory bowel disease (IBD) 1/926 56/7206 0.0078425103822 ko04014 Ras signaling pathway 51/926 279/7206 0.00794698349227 ko04925 Aldosterone synthesis and secretion 23/926 105/7206 0.00801022125641 ko04924 Renin secretion 20/926 86/7206 0.00833723567911 ko04371 Apelin signaling pathway 35/926 177/7206 0.00846716868489 ko05145 Toxoplasmosis 7/926 126/7206 0.0102964500261 ko01200 Carbon metabolism 7/926 128/7206 0.0105491432778 ko00280 Valine, leucine and isoleucine degradation 1/926 54/7206 0.0121038958546 ko04612 Antigen processing and presentation 3/926 77/7206 0.0151931260479 ko05161 Hepatitis B 12/926 173/7206 0.0155325552078 ko05166 HTLV-I infection 24/926 292/7206 0.0155625667163 ko04976 Bile secretion 18/926 80/7206 0.0169677252424 ko00561 Glycerolipid metabolism 2/926 63/7206 0.0208476103491 ko04214 Apoptosis - fly 3/926 72/7206 0.0210466772249 ko04217 Necroptosis 13/926 178/7206 0.0229676198261 ko04745 Phototransduction - fly 10/926 38/7206 0.0241236343342 ko05144 Malaria 1/926 45/7206 0.0248992144787 ko00071 Fatty acid degradation 1/926 45/7206 0.0248992144787 ko00620 Pyruvate metabolism 1/926 46/7206 0.0250486303401 ko03420 Nucleotide excision repair 1/926 46/7206 0.0250486303401 ko04391 Hippo signaling pathway - fly 19/926 90/7206 0.0253897181636 ko04138 Autophagy - yeast 4/926 81/7206 0.0291208583443 ko04140 Autophagy - animal 12/926 164/7206 0.0328434145701 ko04932 Non-alcoholic fatty liver disease (NAFLD) 14/926 182/7206 0.0329136169662 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/926 15/7206 0.0344168689867 ko00983 Drug metabolism - other enzymes 1/926 42/7206 0.0366195424365 ko05418 Fluid shear stress and atherosclerosis 13/926 173/7206 0.0374628699356 ko03022 Basal transcription factors 1/926 44/7206 0.0379867679328 ko04668 TNF signaling pathway 8/926 120/7206 0.0388724023399 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/926 92/7206 0.0393772372416 ko04072 Phospholipase D signaling pathway 35/926 197/7206 0.0403181730132 ko00480 Glutathione metabolism 2/926 55/7206 0.0408239802545 ko04962 Vasopressin-regulated water reabsorption 13/926 58/7206 0.0451834286268