ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 35/571 79/7206 1.27578438097e-18 ko04974 Protein digestion and absorption 34/571 96/7206 1.42350176976e-14 ko04260 Cardiac muscle contraction 27/571 98/7206 4.87382020029e-09 ko04976 Bile secretion 23/571 80/7206 2.83239845795e-08 ko04978 Mineral absorption 15/571 40/7206 1.5828397833e-07 ko04080 Neuroactive ligand-receptor interaction 60/571 423/7206 6.52036504728e-06 ko01200 Carbon metabolism 25/571 128/7206 1.84512906419e-05 ko04977 Vitamin digestion and absorption 9/571 22/7206 2.24986440066e-05 ko01230 Biosynthesis of amino acids 19/571 85/7206 2.65069855379e-05 ko05410 Hypertrophic cardiomyopathy (HCM) 21/571 100/7206 2.76954526626e-05 ko04964 Proximal tubule bicarbonate reclamation 10/571 29/7206 4.52843312831e-05 ko04975 Fat digestion and absorption 11/571 35/7206 5.04239454579e-05 ko04973 Carbohydrate digestion and absorption 12/571 42/7206 6.61042313784e-05 ko05150 Staphylococcus aureus infection 11/571 36/7206 6.7489912703e-05 ko05166 HTLV-I infection 7/571 292/7206 8.69724610094e-05 ko03040 Spliceosome 1/571 145/7206 0.000136081185446 ko04972 Pancreatic secretion 21/571 111/7206 0.000137646207563 ko00010 Glycolysis / Gluconeogenesis 16/571 74/7206 0.000172512789944 ko03013 RNA transport 2/571 166/7206 0.000211634990553 ko00260 Glycine, serine and threonine metabolism 12/571 48/7206 0.00026813489579 ko04950 Maturity onset diabetes of the young 9/571 29/7206 0.000273631635625 ko04614 Renin-angiotensin system 7/571 18/7206 0.000277492117969 ko04924 Renin secretion 17/571 86/7206 0.000342276348268 ko04911 Insulin secretion 21/571 117/7206 0.000354662444231 ko04512 ECM-receptor interaction 16/571 79/7206 0.000381378229006 ko00350 Tyrosine metabolism 9/571 33/7206 0.000791093088588 ko00680 Methane metabolism 9/571 34/7206 0.00100163922789 ko04140 Autophagy - animal 3/571 164/7206 0.00115115724478 ko04550 Signaling pathways regulating pluripotency of stem cells 3/571 165/7206 0.00115343685072 ko05414 Dilated cardiomyopathy 19/571 112/7206 0.00124697514014 ko00983 Drug metabolism - other enzymes 10/571 42/7206 0.00129870005288 ko00220 Arginine biosynthesis 7/571 24/7206 0.00198439764527 ko04120 Ubiquitin mediated proteolysis 2/571 138/7206 0.00201919409947 ko04621 NOD-like receptor signaling pathway 3/571 157/7206 0.00237899129913 ko05161 Hepatitis B 4/571 173/7206 0.00257092280314 ko04142 Lysosome 3/571 151/7206 0.00331454204467 ko04970 Salivary secretion 16/571 95/7206 0.00335534712903 ko00980 Metabolism of xenobiotics by cytochrome P450 9/571 40/7206 0.00340495357058 ko05204 Chemical carcinogenesis 10/571 48/7206 0.00375208867565 ko04060 Cytokine-cytokine receptor interaction 5/571 191/7206 0.00386654846238 ko05033 Nicotine addiction 11/571 56/7206 0.003913190616 ko04660 T cell receptor signaling pathway 2/571 124/7206 0.00394778477862 ko00710 Carbon fixation in photosynthetic organisms 7/571 27/7206 0.00413401750651 ko05203 Viral carcinogenesis 10/571 277/7206 0.00435778530222 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/571 5/7206 0.00438410396734 ko05168 Herpes simplex infection 5/571 182/7206 0.0051319286695 ko04310 Wnt signaling pathway 5/571 181/7206 0.00513690795506 ko04141 Protein processing in endoplasmic reticulum 5/571 184/7206 0.00518577290158 ko04144 Endocytosis 14/571 342/7206 0.00537322049358 ko05162 Measles 2/571 120/7206 0.00567985998959 ko04114 Oocyte meiosis 3/571 139/7206 0.00645841207742 ko04360 Axon guidance 8/571 233/7206 0.00646892506162 ko04658 Th1 and Th2 cell differentiation 1/571 96/7206 0.00653514311848 ko00190 Oxidative phosphorylation 19/571 127/7206 0.00691754077826 ko04510 Focal adhesion 31/571 240/7206 0.00694043930401 ko04217 Necroptosis 5/571 178/7206 0.00705075975406 ko00330 Arginine and proline metabolism 11/571 61/7206 0.00766710750718 ko04261 Adrenergic signaling in cardiomyocytes 27/571 205/7206 0.00815174854993 ko00250 Alanine, aspartate and glutamate metabolism 8/571 38/7206 0.00861803898409 ko00630 Glyoxylate and dicarboxylate metabolism 8/571 38/7206 0.00861803898409 ko04111 Cell cycle - yeast 1/571 90/7206 0.00940774045151 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 13/571 79/7206 0.0100546477178 ko00480 Glutathione metabolism 10/571 55/7206 0.0101793951967 ko04740 Olfactory transduction 13/571 80/7206 0.0108952144982 ko05010 Alzheimer's disease 26/571 202/7206 0.0118102346704 ko04971 Gastric acid secretion 15/571 98/7206 0.0125428893393 ko04390 Hippo signaling pathway 6/571 188/7206 0.012861009679 ko04657 IL-17 signaling pathway 1/571 87/7206 0.0142344171975 ko04713 Circadian entrainment 19/571 136/7206 0.0147868317228 ko04723 Retrograde endocannabinoid signaling 23/571 175/7206 0.0150944380041 ko00830 Retinol metabolism 8/571 42/7206 0.0157403436362 ko04062 Chemokine signaling pathway 7/571 201/7206 0.0162065039554 ko04914 Progesterone-mediated oocyte maturation 2/571 104/7206 0.0163098945945 ko04211 Longevity regulating pathway 3/571 123/7206 0.0175427086723 ko00500 Starch and sucrose metabolism 7/571 35/7206 0.0180429326762 ko04110 Cell cycle 4/571 145/7206 0.0183254900647 ko03008 Ribosome biogenesis in eukaryotes 1/571 79/7206 0.0198055050948 ko04022 cGMP-PKG signaling pathway 27/571 216/7206 0.0202273316722 ko04138 Autophagy - yeast 1/571 81/7206 0.020287717662 ko03320 PPAR signaling pathway 11/571 69/7206 0.0221312353397 ko05206 MicroRNAs in cancer 6/571 177/7206 0.0228984629879 ko00982 Drug metabolism - cytochrome P450 7/571 37/7206 0.0240959293098 ko04668 TNF signaling pathway 3/571 120/7206 0.0247940966703 ko05169 Epstein-Barr virus infection 8/571 206/7206 0.0256870167408 ko00053 Ascorbate and aldarate metabolism 5/571 22/7206 0.0260895663929 ko05034 Alcoholism 10/571 238/7206 0.0276506240896 ko05152 Tuberculosis 7/571 187/7206 0.0278368995696 ko05012 Parkinson's disease 20/571 155/7206 0.0333162193077 ko04070 Phosphatidylinositol signaling system 3/571 112/7206 0.0335580005824 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/571 4/7206 0.0337687272334 ko04650 Natural killer cell mediated cytotoxicity 2/571 97/7206 0.0341159635963 ko04933 AGE-RAGE signaling pathway in diabetic complications 4/571 135/7206 0.034262698244 ko04150 mTOR signaling pathway 7/571 184/7206 0.0368011923191 ko00030 Pentose phosphate pathway 6/571 32/7206 0.0371491317808 ko05200 Pathways in cancer 27/571 492/7206 0.0377468533073 ko00950 Isoquinoline alkaloid biosynthesis 3/571 10/7206 0.0389911307077 ko04960 Aldosterone-regulated sodium reabsorption 7/571 41/7206 0.0400906540845 ko00140 Steroid hormone biosynthesis 7/571 41/7206 0.0400906540845 ko00360 Phenylalanine metabolism 4/571 17/7206 0.040486898451 ko05164 Influenza A 6/571 167/7206 0.0405366881476 ko05217 Basal cell carcinoma 1/571 68/7206 0.0415595358954 ko00340 Histidine metabolism 5/571 25/7206 0.0433060354325 ko04670 Leukocyte transendothelial migration 19/571 151/7206 0.0455371186236 ko01521 EGFR tyrosine kinase inhibitor resistance 3/571 106/7206 0.0461455176381 ko04218 Cellular senescence 7/571 177/7206 0.0477100155209 ko04270 Vascular smooth muscle contraction 19/571 154/7206 0.0487371193931