ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 35/273 191/7206 2.70030743629e-15 ko04650 Natural killer cell mediated cytotoxicity 25/273 97/7206 8.59146582352e-15 ko05330 Allograft rejection 12/273 24/7206 1.24077041531e-11 ko05340 Primary immunodeficiency 13/273 30/7206 1.67930511385e-11 ko05140 Leishmaniasis 19/273 75/7206 2.23346689863e-11 ko04659 Th17 cell differentiation 22/273 106/7206 4.05131763211e-11 ko04380 Osteoclast differentiation 24/273 134/7206 1.34875027023e-10 ko05332 Graft-versus-host disease 10/273 18/7206 1.73257420437e-10 ko05152 Tuberculosis 28/273 187/7206 2.95039380033e-10 ko04612 Antigen processing and presentation 18/273 77/7206 3.23398313193e-10 ko05321 Inflammatory bowel disease (IBD) 15/273 56/7206 1.30366629708e-09 ko05145 Toxoplasmosis 22/273 126/7206 1.36202146953e-09 ko05320 Autoimmune thyroid disease 11/273 29/7206 3.56249593365e-09 ko05164 Influenza A 24/273 167/7206 1.35899257647e-08 ko05162 Measles 20/273 120/7206 1.80243401954e-08 ko05150 Staphylococcus aureus infection 11/273 36/7206 4.88108352754e-08 ko04640 Hematopoietic cell lineage 14/273 64/7206 7.85300647155e-08 ko04658 Th1 and Th2 cell differentiation 17/273 96/7206 8.72326677602e-08 ko04145 Phagosome 22/273 162/7206 1.57601907946e-07 ko04940 Type I diabetes mellitus 10/273 32/7206 1.59348120081e-07 ko04217 Necroptosis 23/273 178/7206 2.05697413677e-07 ko04621 NOD-like receptor signaling pathway 21/273 157/7206 3.9554571214e-07 ko05168 Herpes simplex infection 22/273 182/7206 1.22086872515e-06 ko05310 Asthma 7/273 17/7206 1.45641401942e-06 ko04660 T cell receptor signaling pathway 17/273 124/7206 3.70728990471e-06 ko04062 Chemokine signaling pathway 22/273 201/7206 6.44267741987e-06 ko04672 Intestinal immune network for IgA production 9/273 37/7206 6.89350181883e-06 ko04630 Jak-STAT signaling pathway 17/273 132/7206 8.77901199441e-06 ko04064 NF-kappa B signaling pathway 14/273 96/7206 1.31974112735e-05 ko04620 Toll-like receptor signaling pathway 14/273 100/7206 2.12689117812e-05 ko03050 Proteasome 10/273 54/7206 2.82359481171e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/273 191/7206 3.29143483554e-05 ko05144 Malaria 9/273 45/7206 3.76201235424e-05 ko04666 Fc gamma R-mediated phagocytosis 15/273 122/7206 5.19011806914e-05 ko04662 B cell receptor signaling pathway 12/273 88/7206 0.00010760654626 ko04611 Platelet activation 17/273 163/7206 0.000135825154747 ko05416 Viral myocarditis 9/273 55/7206 0.000193653417735 ko05323 Rheumatoid arthritis 11/273 89/7206 0.000497741041845 ko04664 Fc epsilon RI signaling pathway 10/273 77/7206 0.000600384863244 ko05142 Chagas disease (American trypanosomiasis) 13/273 130/7206 0.00123139780035 ko04514 Cell adhesion molecules (CAMs) 13/273 130/7206 0.00123139780035 ko04670 Leukocyte transendothelial migration 14/273 151/7206 0.00168556799318 ko00590 Arachidonic acid metabolism 7/273 52/7206 0.00321791683632 ko05133 Pertussis 9/273 87/7206 0.00543973733614 ko05161 Hepatitis B 14/273 173/7206 0.0069996231498 ko04622 RIG-I-like receptor signaling pathway 7/273 62/7206 0.00858612202242 ko05034 Alcoholism 2/273 238/7206 0.00890034611685 ko04610 Complement and coagulation cascades 8/273 79/7206 0.00973286890134 ko04728 Dopaminergic synapse 1/273 185/7206 0.0104039195845 ko05132 Salmonella infection 9/273 98/7206 0.0116499369805 ko05146 Amoebiasis 9/273 99/7206 0.0124040150645 ko04723 Retrograde endocannabinoid signaling 1/273 175/7206 0.0150650101023 ko04310 Wnt signaling pathway 1/273 181/7206 0.015613421405 ko04072 Phospholipase D signaling pathway 14/273 197/7206 0.0212271570794 ko04144 Endocytosis 21/273 342/7206 0.0280335197138 ko04142 Lysosome 11/273 151/7206 0.0306839885056 ko05143 African trypanosomiasis 4/273 32/7206 0.0314695597161 ko04152 AMPK signaling pathway 1/273 161/7206 0.0328224104707 ko04360 Axon guidance 3/273 233/7206 0.0359262291869 ko05010 Alzheimer's disease 2/273 202/7206 0.036454938966 ko03040 Spliceosome 1/273 145/7206 0.0452763908152 ko04390 Hippo signaling pathway 2/273 188/7206 0.0497380731329