ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 47/512 191/7206 1.29523734489e-14 ko04380 Osteoclast differentiation 38/512 134/7206 3.86499503785e-14 ko04621 NOD-like receptor signaling pathway 40/512 157/7206 3.95106660308e-13 ko05164 Influenza A 36/512 167/7206 1.01854352657e-09 ko04064 NF-kappa B signaling pathway 25/512 96/7206 6.98917188085e-09 ko05140 Leishmaniasis 21/512 75/7206 2.86709998707e-08 ko05340 Primary immunodeficiency 13/512 30/7206 3.94602544257e-08 ko05168 Herpes simplex infection 35/512 182/7206 4.00944251338e-08 ko04659 Th17 cell differentiation 25/512 106/7206 6.03679842343e-08 ko05145 Toxoplasmosis 27/512 126/7206 1.50797669891e-07 ko05321 Inflammatory bowel disease (IBD) 17/512 56/7206 1.67124939244e-07 ko05162 Measles 26/512 120/7206 2.03839913657e-07 ko04217 Necroptosis 33/512 178/7206 2.44258422219e-07 ko04620 Toll-like receptor signaling pathway 23/512 100/7206 3.34099479117e-07 ko04658 Th1 and Th2 cell differentiation 22/512 96/7206 6.44714710173e-07 ko04672 Intestinal immune network for IgA production 13/512 37/7206 7.38313157379e-07 ko04650 Natural killer cell mediated cytotoxicity 22/512 97/7206 7.7956705406e-07 ko04660 T cell receptor signaling pathway 25/512 124/7206 1.46370531926e-06 ko00120 Primary bile acid biosynthesis 9/512 20/7206 3.55968211199e-06 ko05161 Hepatitis B 30/512 173/7206 3.69661538678e-06 ko05133 Pertussis 19/512 87/7206 7.99095567653e-06 ko04668 TNF signaling pathway 23/512 120/7206 9.40531460871e-06 ko05323 Rheumatoid arthritis 19/512 89/7206 1.13335944381e-05 ko04630 Jak-STAT signaling pathway 24/512 132/7206 1.53969934087e-05 ko05150 Staphylococcus aureus infection 11/512 36/7206 2.45310561047e-05 ko05152 Tuberculosis 29/512 187/7206 6.16898405368e-05 ko04723 Retrograde endocannabinoid signaling 1/512 175/7206 6.79151405382e-05 ko04612 Antigen processing and presentation 16/512 77/7206 7.85842740187e-05 ko04622 RIG-I-like receptor signaling pathway 14/512 62/7206 8.47295058426e-05 ko04623 Cytosolic DNA-sensing pathway 11/512 41/7206 9.31163675611e-05 ko00140 Steroid hormone biosynthesis 11/512 41/7206 9.31163675611e-05 ko05320 Autoimmune thyroid disease 9/512 29/7206 0.000118936034209 ko04662 B cell receptor signaling pathway 17/512 88/7206 0.000123602999873 ko05330 Allograft rejection 8/512 24/7206 0.000163326909608 ko05142 Chagas disease (American trypanosomiasis) 22/512 130/7206 0.000169991056561 ko05144 Malaria 11/512 45/7206 0.000230629888178 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/512 191/7206 0.00025759145207 ko04657 IL-17 signaling pathway 16/512 87/7206 0.000350865356831 ko00350 Tyrosine metabolism 9/512 33/7206 0.000354490390279 ko03040 Spliceosome 1/512 145/7206 0.000457385599579 ko04933 AGE-RAGE signaling pathway in diabetic complications 21/512 135/7206 0.000546919509239 ko05034 Alcoholism 5/512 238/7206 0.000763796574037 ko00360 Phenylalanine metabolism 6/512 17/7206 0.000785783973948 ko04210 Apoptosis 25/512 180/7206 0.00104643662372 ko05332 Graft-versus-host disease 6/512 18/7206 0.00110869047292 ko04062 Chemokine signaling pathway 27/512 201/7206 0.00116964130475 ko05160 Hepatitis C 22/512 153/7206 0.00125772235984 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/512 4/7206 0.00135135556196 ko00592 alpha-Linolenic acid metabolism 6/512 19/7206 0.00152431803668 ko04611 Platelet activation 23/512 163/7206 0.00162282234939 ko05131 Shigellosis 14/512 82/7206 0.00171994178915 ko04724 Glutamatergic synapse 2/512 152/7206 0.00201897025195 ko05132 Salmonella infection 16/512 98/7206 0.00205057094397 ko00590 Arachidonic acid metabolism 10/512 52/7206 0.00314327649735 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/512 5/7206 0.00319998703108 ko04610 Complement and coagulation cascades 13/512 79/7206 0.00347266562835 ko00950 Isoquinoline alkaloid biosynthesis 4/512 10/7206 0.00374432966059 ko04360 Axon guidance 6/512 233/7206 0.00394151955458 ko04080 Neuroactive ligand-receptor interaction 16/512 423/7206 0.00447959643166 ko04727 GABAergic synapse 1/512 110/7206 0.00450893746854 ko05032 Morphine addiction 1/512 110/7206 0.00450893746854 ko00254 Aflatoxin biosynthesis 2/512 2/7206 0.00503921186818 ko04728 Dopaminergic synapse 4/512 185/7206 0.00522820191696 ko05310 Asthma 5/512 17/7206 0.00536443253622 ko04666 Fc gamma R-mediated phagocytosis 17/512 122/7206 0.00666197844891 ko04512 ECM-receptor interaction 12/512 79/7206 0.0122216080506 ko04713 Circadian entrainment 3/512 136/7206 0.0179025097568 ko04120 Ubiquitin mediated proteolysis 3/512 138/7206 0.0179991257687 ko04310 Wnt signaling pathway 5/512 181/7206 0.0180369789268 ko04114 Oocyte meiosis 3/512 139/7206 0.0181440826179 ko05016 Huntington's disease 7/512 215/7206 0.0215081360997 ko04940 Type I diabetes mellitus 6/512 32/7206 0.0232023223961 ko04972 Pancreatic secretion 2/512 111/7206 0.0237076414787 ko04931 Insulin resistance 17/512 137/7206 0.0266643871809 ko00051 Fructose and mannose metabolism 7/512 42/7206 0.0269471639968 ko00643 Styrene degradation 2/512 4/7206 0.0274569317196 ko05146 Amoebiasis 13/512 99/7206 0.0279302522481 ko04145 Phagosome 19/512 162/7206 0.0288508290617 ko03320 PPAR signaling pathway 10/512 69/7206 0.0290008005292 ko00920 Sulfur metabolism 3/512 10/7206 0.0293685141071 ko04390 Hippo signaling pathway 6/512 188/7206 0.0304113958763 ko04110 Cell cycle 4/512 145/7206 0.0336829601606 ko01200 Carbon metabolism 3/512 128/7206 0.0348849247054 ko05215 Prostate cancer 14/512 111/7206 0.0371459052185 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/512 92/7206 0.0376693825676 ko05134 Legionellosis 10/512 74/7206 0.0396007693741 ko00281 Geraniol degradation 2/512 5/7206 0.043628228179 ko04550 Signaling pathways regulating pluripotency of stem cells 5/512 165/7206 0.044100680128 ko04740 Olfactory transduction 1/512 80/7206 0.0442496124143 ko04916 Melanogenesis 4/512 142/7206 0.0458748732268 ko04720 Long-term potentiation 2/512 99/7206 0.046700628977 ko05212 Pancreatic cancer 11/512 83/7206 0.0478033633617