ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 45/830 56/7206 8.41974786136e-33 ko04724 Glutamatergic synapse 69/830 152/7206 2.40169416749e-26 ko04080 Neuroactive ligand-receptor interaction 126/830 423/7206 5.01903634784e-26 ko04727 GABAergic synapse 53/830 110/7206 5.80333556228e-22 ko05032 Morphine addiction 53/830 110/7206 5.80333556228e-22 ko04721 Synaptic vesicle cycle 41/830 80/7206 1.6676657086e-18 ko04723 Retrograde endocannabinoid signaling 62/830 175/7206 3.87668108218e-17 ko04728 Dopaminergic synapse 63/830 185/7206 2.00223803169e-16 ko04744 Phototransduction 25/830 36/7206 4.24789302284e-16 ko04713 Circadian entrainment 50/830 136/7206 8.87420231086e-15 ko04725 Cholinergic synapse 53/830 160/7206 1.94461606884e-13 ko04911 Insulin secretion 39/830 117/7206 2.6064287817e-10 ko04024 cAMP signaling pathway 69/830 279/7206 3.11172530733e-10 ko04742 Taste transduction 26/830 61/7206 6.26079643362e-10 ko04726 Serotonergic synapse 41/830 137/7206 3.59206214174e-09 ko05203 Viral carcinogenesis 8/830 277/7206 2.22338206186e-07 ko05030 Cocaine addiction 25/830 73/7206 2.4361478573e-07 ko03040 Spliceosome 1/830 145/7206 5.43222406193e-07 ko04514 Cell adhesion molecules (CAMs) 35/830 130/7206 9.79875439766e-07 ko04261 Adrenergic signaling in cardiomyocytes 48/830 205/7206 1.06954077497e-06 ko05031 Amphetamine addiction 27/830 91/7206 2.07388216225e-06 ko05164 Influenza A 3/830 167/7206 3.61579388903e-06 ko04740 Olfactory transduction 24/830 80/7206 6.16301081974e-06 ko04120 Ubiquitin mediated proteolysis 2/830 138/7206 1.11814557154e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 22/830 74/7206 1.75330781266e-05 ko04921 Oxytocin signaling pathway 45/830 209/7206 2.33600634308e-05 ko04970 Salivary secretion 25/830 95/7206 5.64727939789e-05 ko05205 Proteoglycans in cancer 12/830 271/7206 5.81105263187e-05 ko05168 Herpes simplex infection 6/830 182/7206 8.83463368945e-05 ko04260 Cardiac muscle contraction 25/830 98/7206 8.97149766057e-05 ko03013 RNA transport 5/830 166/7206 0.000110586773656 ko04060 Cytokine-cytokine receptor interaction 7/830 191/7206 0.000192680527324 ko04010 MAPK signaling pathway 59/830 321/7206 0.000220353387784 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/830 79/7206 0.000223564035774 ko04621 NOD-like receptor signaling pathway 5/830 157/7206 0.000322195563548 ko04720 Long-term potentiation 24/830 99/7206 0.000340134161881 ko04966 Collecting duct acid secretion 10/830 26/7206 0.000366226854008 ko05322 Systemic lupus erythematosus 5/830 151/7206 0.000438552914976 ko05162 Measles 3/830 120/7206 0.000466160594223 ko04140 Autophagy - animal 6/830 164/7206 0.000473834117904 ko04141 Protein processing in endoplasmic reticulum 8/830 184/7206 0.000946072371096 ko04964 Proximal tubule bicarbonate reclamation 10/830 29/7206 0.00100048487686 ko05166 HTLV-I infection 17/830 292/7206 0.00100641457272 ko04730 Long-term depression 19/830 78/7206 0.00113896803135 ko03008 Ribosome biogenesis in eukaryotes 1/830 79/7206 0.0011521035521 ko04974 Protein digestion and absorption 22/830 96/7206 0.001759365404 ko04976 Bile secretion 19/830 80/7206 0.00209130059833 ko04972 Pancreatic secretion 24/830 111/7206 0.00227268005718 ko05161 Hepatitis B 8/830 173/7206 0.00236707384082 ko05169 Epstein-Barr virus infection 11/830 206/7206 0.00369179468232 ko04022 cGMP-PKG signaling pathway 39/830 216/7206 0.00456652264172 ko04137 Mitophagy - animal 2/830 82/7206 0.00488390797733 ko03018 RNA degradation 2/830 84/7206 0.00504674580352 ko04064 NF-kappa B signaling pathway 3/830 96/7206 0.00563436078014 ko05215 Prostate cancer 4/830 111/7206 0.00621824574216 ko04932 Non-alcoholic fatty liver disease (NAFLD) 10/830 182/7206 0.00673285727615 ko00330 Arginine and proline metabolism 1/830 61/7206 0.0081573781445 ko00561 Glycerolipid metabolism 1/830 63/7206 0.00841425523959 ko04640 Hematopoietic cell lineage 1/830 64/7206 0.00874914148408 ko04745 Phototransduction - fly 10/830 38/7206 0.00904671058986 ko05140 Leishmaniasis 2/830 75/7206 0.0101205689707 ko04146 Peroxisome 3/830 89/7206 0.011245744935 ko04218 Cellular senescence 10/830 177/7206 0.0117042932723 ko04217 Necroptosis 10/830 178/7206 0.0118609846497 ko04810 Regulation of actin cytoskeleton 18/830 264/7206 0.013674892676 ko04214 Apoptosis - fly 2/830 72/7206 0.0145851348867 ko04211 Longevity regulating pathway 6/830 123/7206 0.015221885452 ko05418 Fluid shear stress and atherosclerosis 10/830 173/7206 0.0152451367981 ko00240 Pyrimidine metabolism 5/830 110/7206 0.0158007784689 ko04360 Axon guidance 39/830 233/7206 0.0158968516573 ko00564 Glycerophospholipid metabolism 4/830 99/7206 0.0162201045682 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/830 14/7206 0.0164652888978 ko05016 Huntington's disease 14/830 215/7206 0.016793245767 ko00480 Glutathione metabolism 1/830 55/7206 0.017821369719 ko01521 EGFR tyrosine kinase inhibitor resistance 5/830 106/7206 0.0214771655207 ko04971 Gastric acid secretion 19/830 98/7206 0.0238546662292 ko04924 Renin secretion 17/830 86/7206 0.0251793152498 ko04540 Gap junction 23/830 128/7206 0.0254526284891 ko00590 Arachidonic acid metabolism 1/830 52/7206 0.0264407311561 ko04020 Calcium signaling pathway 42/830 265/7206 0.0304747167756 ko04612 Antigen processing and presentation 3/830 77/7206 0.0305860705125 ko01200 Carbon metabolism 7/830 128/7206 0.0345451658535 ko00270 Cysteine and methionine metabolism 1/830 47/7206 0.0379877008811 ko00260 Glycine, serine and threonine metabolism 1/830 48/7206 0.0383746902563 ko05219 Bladder cancer 1/830 48/7206 0.0383746902563 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/830 59/7206 0.0403604381344 ko04657 IL-17 signaling pathway 4/830 87/7206 0.0413542321363 ko05133 Pertussis 4/830 87/7206 0.0413542321363 ko04978 Mineral absorption 9/830 40/7206 0.0422987312434 ko04115 p53 signaling pathway 3/830 74/7206 0.0425978510862 ko01524 Platinum drug resistance 3/830 76/7206 0.0439895051564 ko04110 Cell cycle 9/830 145/7206 0.0473907930091