ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 150/984 423/7206 5.39262690716e-32 ko04724 Glutamatergic synapse 77/984 152/7206 2.74778073291e-28 ko05033 Nicotine addiction 42/984 56/7206 1.89164859484e-25 ko05032 Morphine addiction 59/984 110/7206 1.44942629173e-23 ko04727 GABAergic synapse 57/984 110/7206 8.07313899819e-22 ko04713 Circadian entrainment 63/984 136/7206 1.14175848493e-20 ko04728 Dopaminergic synapse 72/984 185/7206 3.65531825764e-18 ko04723 Retrograde endocannabinoid signaling 68/984 175/7206 3.60634587398e-17 ko04024 cAMP signaling pathway 89/984 279/7206 9.89557032533e-16 ko04020 Calcium signaling pathway 86/984 265/7206 1.21190521869e-15 ko04725 Cholinergic synapse 61/984 160/7206 4.61565744683e-15 ko04721 Synaptic vesicle cycle 38/984 80/7206 2.21770769938e-13 ko04911 Insulin secretion 47/984 117/7206 7.3859441584e-13 ko04921 Oxytocin signaling pathway 67/984 209/7206 4.2016018518e-12 ko04726 Serotonergic synapse 48/984 137/7206 1.35283196378e-10 ko05031 Amphetamine addiction 37/984 91/7206 1.40355365168e-10 ko04261 Adrenergic signaling in cardiomyocytes 61/984 205/7206 1.28120888766e-09 ko04925 Aldosterone synthesis and secretion 38/984 105/7206 4.12294579085e-09 ko04742 Taste transduction 27/984 61/7206 4.86907918057e-09 ko03040 Spliceosome 1/984 145/7206 2.3647983389e-08 ko05030 Cocaine addiction 29/984 73/7206 2.62274671935e-08 ko04010 MAPK signaling pathway 80/984 321/7206 2.77295331612e-08 ko04720 Long-term potentiation 35/984 99/7206 3.39035607648e-08 ko03010 Ribosome 1/984 129/7206 1.82343059772e-07 ko05322 Systemic lupus erythematosus 3/984 151/7206 9.04052844685e-07 ko04360 Axon guidance 59/984 233/7206 1.36897069735e-06 ko04072 Phospholipase D signaling pathway 52/984 197/7206 1.43506805685e-06 ko04022 cGMP-PKG signaling pathway 55/984 216/7206 2.56430421582e-06 ko04070 Phosphatidylinositol signaling system 34/984 112/7206 4.30448658786e-06 ko04970 Salivary secretion 29/984 95/7206 1.53230809295e-05 ko03013 RNA transport 6/984 166/7206 1.84873846471e-05 ko04710 Circadian rhythm 17/984 43/7206 2.21839163316e-05 ko04514 Cell adhesion molecules (CAMs) 36/984 130/7206 2.37059987159e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 23/984 74/7206 9.86859895344e-05 ko04014 Ras signaling pathway 61/984 279/7206 0.000120229646541 ko00240 Pyrimidine metabolism 3/984 110/7206 0.000201140129424 ko03008 Ribosome biogenesis in eukaryotes 1/984 79/7206 0.000202345220036 ko04972 Pancreatic secretion 30/984 111/7206 0.00021221037002 ko04612 Antigen processing and presentation 1/984 77/7206 0.000312194230319 ko04730 Long-term depression 23/984 78/7206 0.00033038645724 ko04141 Protein processing in endoplasmic reticulum 10/984 184/7206 0.000441196867511 ko04971 Gastric acid secretion 26/984 98/7206 0.000567403821511 ko04060 Cytokine-cytokine receptor interaction 11/984 191/7206 0.00057657830101 ko04711 Circadian rhythm - fly 7/984 13/7206 0.000701498968487 ko04915 Estrogen signaling pathway 32/984 131/7206 0.000744092393082 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/984 79/7206 0.000763486909517 ko04961 Endocrine and other factor-regulated calcium reabsorption 18/984 59/7206 0.000771609056201 ko05164 Influenza A 9/984 167/7206 0.00083581526467 ko04110 Cell cycle 7/984 145/7206 0.000842559137446 ko00562 Inositol phosphate metabolism 24/984 89/7206 0.000849842115838 ko05203 Viral carcinogenesis 20/984 277/7206 0.000899740669022 ko04930 Type II diabetes mellitus 17/984 54/7206 0.000918632605229 ko04922 Glucagon signaling pathway 31/984 128/7206 0.00104911674634 ko04350 TGF-beta signaling pathway 4/984 103/7206 0.00203744395631 ko04750 Inflammatory mediator regulation of TRP channels 29/984 122/7206 0.00206883936773 ko04924 Renin secretion 22/984 86/7206 0.00250878152471 ko05414 Dilated cardiomyopathy 27/984 112/7206 0.00312432423466 ko04745 Phototransduction - fly 12/984 38/7206 0.00349941650356 ko04371 Apelin signaling pathway 38/984 177/7206 0.00373385787871 ko04260 Cardiac muscle contraction 24/984 98/7206 0.00424367817574 ko05231 Choline metabolism in cancer 30/984 134/7206 0.00494030932093 ko04213 Longevity regulating pathway - multiple species 21/984 86/7206 0.00652570596991 ko04744 Phototransduction 11/984 36/7206 0.0067286355841 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/984 14/7206 0.00721090307303 ko05168 Herpes simplex infection 13/984 182/7206 0.00827677588529 ko04540 Gap junction 28/984 128/7206 0.00913297335294 ko05133 Pertussis 4/984 87/7206 0.0109196324673 ko04923 Regulation of lipolysis in adipocytes 19/984 77/7206 0.010931718064 ko04740 Olfactory transduction 19/984 80/7206 0.0130949506621 ko01212 Fatty acid metabolism 2/984 60/7206 0.0134196104748 ko05110 Vibrio cholerae infection 16/984 63/7206 0.0145589894969 ko04015 Rap1 signaling pathway 52/984 278/7206 0.0158888539753 ko03420 Nucleotide excision repair 1/984 46/7206 0.0164462584602 ko04610 Complement and coagulation cascades 4/984 79/7206 0.0206074913256 ko03320 PPAR signaling pathway 3/984 69/7206 0.0206462799817 ko05162 Measles 8/984 120/7206 0.0220871923369 ko03022 Basal transcription factors 1/984 44/7206 0.0248205371926 ko04621 NOD-like receptor signaling pathway 12/984 157/7206 0.0250702217636 ko00071 Fatty acid degradation 1/984 45/7206 0.0258460313393 ko04722 Neurotrophin signaling pathway 32/984 160/7206 0.0260404321521 ko04918 Thyroid hormone synthesis 19/984 86/7206 0.0269413358284 ko00280 Valine, leucine and isoleucine degradation 2/984 54/7206 0.0277047674087 ko05130 Pathogenic Escherichia coli infection 4/984 77/7206 0.0286351269898 ko05205 Proteoglycans in cancer 25/984 271/7206 0.0301408909236 ko00430 Taurine and hypotaurine metabolism 5/984 14/7206 0.0324831368975 ko04666 Fc gamma R-mediated phagocytosis 25/984 122/7206 0.0327544156928 ko04114 Oocyte meiosis 28/984 139/7206 0.032921322318 ko04211 Longevity regulating pathway 25/984 123/7206 0.034157972717 ko05016 Huntington's disease 19/984 215/7206 0.0342842878419 ko00980 Metabolism of xenobiotics by cytochrome P450 1/984 40/7206 0.0358927243059 ko04210 Apoptosis 15/984 180/7206 0.0361207618528 ko00140 Steroid hormone biosynthesis 1/984 41/7206 0.0366269593294 ko00983 Drug metabolism - other enzymes 1/984 42/7206 0.0380906064632 ko05410 Hypertrophic cardiomyopathy (HCM) 21/984 100/7206 0.0390659133998 ko00590 Arachidonic acid metabolism 2/984 52/7206 0.0401212756431 ko05140 Leishmaniasis 4/984 75/7206 0.040166023598 ko04622 RIG-I-like receptor signaling pathway 3/984 62/7206 0.0401739124797 ko00680 Methane metabolism 9/984 34/7206 0.0413570998975 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/984 15/7206 0.0433991817214 ko04071 Sphingolipid signaling pathway 31/984 162/7206 0.0483011815105