ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 74/897 152/7206 1.93215208077e-28 ko04080 Neuroactive ligand-receptor interaction 136/897 423/7206 2.59892167596e-28 ko05033 Nicotine addiction 38/897 56/7206 4.64451038936e-22 ko04721 Synaptic vesicle cycle 45/897 80/7206 5.38469033247e-21 ko04728 Dopaminergic synapse 68/897 185/7206 7.54413945773e-18 ko04713 Circadian entrainment 56/897 136/7206 1.70184983327e-17 ko05032 Morphine addiction 49/897 110/7206 3.83884057863e-17 ko04727 GABAergic synapse 48/897 110/7206 2.24962502723e-16 ko04725 Cholinergic synapse 58/897 160/7206 4.55562253648e-15 ko04723 Retrograde endocannabinoid signaling 59/897 175/7206 1.09244419127e-13 ko04024 cAMP signaling pathway 77/897 279/7206 3.26968809138e-12 ko04911 Insulin secretion 42/897 117/7206 4.30289429756e-11 ko04742 Taste transduction 27/897 61/7206 6.0574797035e-10 ko05031 Amphetamine addiction 33/897 91/7206 3.98713408462e-09 ko04726 Serotonergic synapse 42/897 137/7206 1.08416469818e-08 ko04261 Adrenergic signaling in cardiomyocytes 54/897 205/7206 3.88626661101e-08 ko04720 Long-term potentiation 33/897 99/7206 4.39952381801e-08 ko04744 Phototransduction 18/897 36/7206 4.40547953659e-08 ko04921 Oxytocin signaling pathway 54/897 209/7206 9.20133410743e-08 ko03040 Spliceosome 1/897 145/7206 1.43356225322e-07 ko05030 Cocaine addiction 26/897 73/7206 2.71991005572e-07 ko04740 Olfactory transduction 27/897 80/7206 5.60837985168e-07 ko04360 Axon guidance 56/897 233/7206 8.01090431957e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 25/897 74/7206 1.43934787383e-06 ko04060 Cytokine-cytokine receptor interaction 5/897 191/7206 1.96828827418e-06 ko04970 Salivary secretion 29/897 95/7206 2.27683649518e-06 ko04514 Cell adhesion molecules (CAMs) 36/897 130/7206 2.43527591617e-06 ko04120 Ubiquitin mediated proteolysis 2/897 138/7206 3.1246233576e-06 ko05164 Influenza A 4/897 167/7206 4.58632588679e-06 ko05168 Herpes simplex infection 5/897 182/7206 6.05496310508e-06 ko05203 Viral carcinogenesis 13/897 277/7206 1.56633082465e-05 ko04966 Collecting duct acid secretion 12/897 26/7206 2.33632493789e-05 ko04020 Calcium signaling pathway 57/897 265/7206 2.46201853049e-05 ko03013 RNA transport 5/897 166/7206 3.76387681076e-05 ko04925 Aldosterone synthesis and secretion 28/897 105/7206 6.79361907907e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/897 14/7206 8.40582975551e-05 ko04010 MAPK signaling pathway 63/897 321/7206 0.000179917376699 ko05162 Measles 3/897 120/7206 0.000215773868334 ko04260 Cardiac muscle contraction 25/897 98/7206 0.000321516541859 ko04621 NOD-like receptor signaling pathway 6/897 157/7206 0.000325202074087 ko04730 Long-term depression 21/897 78/7206 0.000429000252521 ko04022 cGMP-PKG signaling pathway 45/897 216/7206 0.000482716296636 ko03008 Ribosome biogenesis in eukaryotes 1/897 79/7206 0.000492148595043 ko04540 Gap junction 30/897 128/7206 0.000582664171582 ko05322 Systemic lupus erythematosus 6/897 151/7206 0.000644716252345 ko04141 Protein processing in endoplasmic reticulum 9/897 184/7206 0.00091006566558 ko04971 Gastric acid secretion 24/897 98/7206 0.00095441604927 ko04745 Phototransduction - fly 12/897 38/7206 0.00157773751872 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/897 79/7206 0.00158618662639 ko04214 Apoptosis - fly 1/897 72/7206 0.00172312090737 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/897 59/7206 0.0021329060135 ko04924 Renin secretion 21/897 86/7206 0.00248597690648 ko04064 NF-kappa B signaling pathway 3/897 96/7206 0.00268931279374 ko04972 Pancreatic secretion 25/897 111/7206 0.00322963394147 ko04640 Hematopoietic cell lineage 1/897 64/7206 0.003610372581 ko04915 Estrogen signaling pathway 28/897 131/7206 0.00451250198948 ko05205 Proteoglycans in cancer 19/897 271/7206 0.00467920031508 ko05169 Epstein-Barr virus infection 13/897 206/7206 0.00511042905603 ko04371 Apelin signaling pathway 35/897 177/7206 0.0052633150024 ko00330 Arginine and proline metabolism 1/897 61/7206 0.00538083454721 ko04146 Peroxisome 3/897 89/7206 0.0054208096354 ko04014 Ras signaling pathway 50/897 279/7206 0.0070659791987 ko05140 Leishmaniasis 2/897 75/7206 0.00713027571527 ko04110 Cell cycle 8/897 145/7206 0.00739117329293 ko00240 Pyrimidine metabolism 5/897 110/7206 0.00820409931418 ko05146 Amoebiasis 4/897 99/7206 0.00826195166281 ko05110 Vibrio cholerae infection 15/897 63/7206 0.0112415670471 ko00280 Valine, leucine and isoleucine degradation 1/897 54/7206 0.0116686873602 ko00480 Glutathione metabolism 1/897 55/7206 0.0119444273617 ko05034 Alcoholism 43/897 238/7206 0.012080730578 ko00590 Arachidonic acid metabolism 1/897 52/7206 0.0177812756072 ko00561 Glycerolipid metabolism 2/897 63/7206 0.0201607657762 ko01524 Platinum drug resistance 3/897 76/7206 0.021578588598 ko04964 Proximal tubule bicarbonate reclamation 8/897 29/7206 0.0218422939741 ko04612 Antigen processing and presentation 3/897 77/7206 0.0220653158964 ko04140 Autophagy - animal 11/897 164/7206 0.0224667528211 ko04976 Bile secretion 17/897 80/7206 0.0250415290476 ko05204 Chemical carcinogenesis 1/897 48/7206 0.0256191740552 ko04962 Vasopressin-regulated water reabsorption 13/897 58/7206 0.0276702247822 ko04072 Phospholipase D signaling pathway 35/897 197/7206 0.0279985820615 ko05414 Dilated cardiomyopathy 22/897 112/7206 0.0290441710619 ko03018 RNA degradation 4/897 84/7206 0.0295305222865 ko01200 Carbon metabolism 8/897 128/7206 0.0300693417357 ko00310 Lysine degradation 3/897 73/7206 0.0303726998874 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/897 15/7206 0.0304242793544 ko04391 Hippo signaling pathway - fly 18/897 90/7206 0.0359699354939 ko03022 Basal transcription factors 1/897 44/7206 0.0371808141923 ko04930 Type II diabetes mellitus 12/897 54/7206 0.0373632548736 ko05166 HTLV-I infection 25/897 292/7206 0.0375602995526 ko05144 Malaria 1/897 45/7206 0.0379178706118 ko00071 Fatty acid degradation 1/897 45/7206 0.0379178706118 ko00620 Pyruvate metabolism 1/897 46/7206 0.0392647936449 ko03420 Nucleotide excision repair 1/897 46/7206 0.0392647936449 ko04916 Melanogenesis 26/897 142/7206 0.0392918107186 ko05145 Toxoplasmosis 8/897 126/7206 0.0397722657072 ko04138 Autophagy - yeast 4/897 81/7206 0.0405743352572 ko03320 PPAR signaling pathway 3/897 69/7206 0.0418383186787 ko05418 Fluid shear stress and atherosclerosis 13/897 173/7206 0.0470856624149 ko05161 Hepatitis B 13/897 173/7206 0.0470856624149