ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	159/1007	423/7206	3.01156949233e-36
ko05032	Morphine addiction	65/1007	110/7206	1.36842816732e-28
ko04724	Glutamatergic synapse	77/1007	152/7206	1.32879196739e-27
ko05033	Nicotine addiction	42/1007	56/7206	4.84509973999e-25
ko04727	GABAergic synapse	60/1007	110/7206	6.3924201203e-24
ko04728	Dopaminergic synapse	79/1007	185/7206	3.39858824665e-22
ko04713	Circadian entrainment	63/1007	136/7206	3.93317860605e-20
ko04723	Retrograde endocannabinoid signaling	72/1007	175/7206	3.38584905103e-19
ko04725	Cholinergic synapse	67/1007	160/7206	2.01273217131e-18
ko04024	cAMP signaling pathway	92/1007	279/7206	1.38451676868e-16
ko04721	Synaptic vesicle cycle	40/1007	80/7206	1.25015321506e-14
ko04726	Serotonergic synapse	53/1007	137/7206	3.93024118333e-13
ko04911	Insulin secretion	47/1007	117/7206	1.74381540006e-12
ko04261	Adrenergic signaling in cardiomyocytes	66/1007	205/7206	1.17572720031e-11
ko04020	Calcium signaling pathway	77/1007	265/7206	8.70670288919e-11
ko04742	Taste transduction	29/1007	61/7206	2.75410868424e-10
ko04360	Axon guidance	67/1007	233/7206	2.10039535881e-09
ko04921	Oxytocin signaling pathway	61/1007	209/7206	6.25445929527e-09
ko03040	Spliceosome	1/1007	145/7206	1.51426772635e-08
ko04744	Phototransduction	19/1007	36/7206	3.99049083799e-08
ko05031	Amphetamine addiction	33/1007	91/7206	7.26815427351e-08
ko05030	Cocaine addiction	28/1007	73/7206	1.82602970352e-07
ko04720	Long-term potentiation	33/1007	99/7206	1.00371300091e-06
ko04970	Salivary secretion	32/1007	95/7206	1.3493999732e-06
ko04010	MAPK signaling pathway	75/1007	321/7206	3.33150702152e-06
ko03013	RNA transport	5/1007	166/7206	3.68564303254e-06
ko05322	Systemic lupus erythematosus	4/1007	151/7206	4.01789795341e-06
ko05203	Viral carcinogenesis	15/1007	277/7206	5.22214529922e-06
ko04022	cGMP-PKG signaling pathway	55/1007	216/7206	5.37010429776e-06
ko04971	Gastric acid secretion	30/1007	98/7206	2.15519133647e-05
ko04925	Aldosterone synthesis and secretion	31/1007	105/7206	2.72754907632e-05
ko04060	Cytokine-cytokine receptor interaction	9/1007	191/7206	4.64580984963e-05
ko04514	Cell adhesion molecules (CAMs)	35/1007	130/7206	9.36983056326e-05
ko04730	Long-term depression	24/1007	78/7206	0.000106277821558
ko05014	Amyotrophic lateral sclerosis (ALS)	23/1007	74/7206	0.000129366228118
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1007	79/7206	0.000129912726473
ko04972	Pancreatic secretion	31/1007	111/7206	0.000138564497781
ko04072	Phospholipase D signaling pathway	47/1007	197/7206	0.000152708184386
ko05164	Influenza A	8/1007	167/7206	0.000164625500883
ko04610	Complement and coagulation cascades	1/1007	79/7206	0.000212896669906
ko03008	Ribosome biogenesis in eukaryotes	1/1007	79/7206	0.000212896669906
ko04141	Protein processing in endoplasmic reticulum	10/1007	184/7206	0.000324046092571
ko04371	Apelin signaling pathway	42/1007	177/7206	0.000393935581304
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1007	59/7206	0.000401618126442
ko04120	Ubiquitin mediated proteolysis	6/1007	138/7206	0.000424108696236
ko04540	Gap junction	32/1007	128/7206	0.000727372536833
ko04924	Renin secretion	24/1007	86/7206	0.000761145268393
ko05414	Dilated cardiomyopathy	29/1007	112/7206	0.000797333544379
ko04070	Phosphatidylinositol signaling system	29/1007	112/7206	0.000797333544379
ko04260	Cardiac muscle contraction	26/1007	98/7206	0.00100204597516
ko05168	Herpes simplex infection	11/1007	182/7206	0.00104062652763
ko04915	Estrogen signaling pathway	32/1007	131/7206	0.00127859490606
ko04612	Antigen processing and presentation	2/1007	77/7206	0.00140931458589
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1007	14/7206	0.00142511763191
ko04014	Ras signaling pathway	58/1007	279/7206	0.00144467090671
ko04621	NOD-like receptor signaling pathway	9/1007	157/7206	0.00151089094398
ko04640	Hematopoietic cell lineage	1/1007	64/7206	0.00156010019452
ko04740	Olfactory transduction	22/1007	80/7206	0.0016132072195
ko05205	Proteoglycans in cancer	21/1007	271/7206	0.00169992392055
ko00330	Arginine and proline metabolism	1/1007	61/7206	0.00231987857781
ko04930	Type II diabetes mellitus	16/1007	54/7206	0.00244606393616
ko04976	Bile secretion	21/1007	80/7206	0.00312373721704
ko04964	Proximal tubule bicarbonate reclamation	10/1007	29/7206	0.00437072291589
ko04923	Regulation of lipolysis in adipocytes	20/1007	77/7206	0.00448569837218
ko00280	Valine, leucine and isoleucine degradation	1/1007	54/7206	0.00497317137331
ko04711	Circadian rhythm - fly	6/1007	13/7206	0.00523219817816
ko04146	Peroxisome	4/1007	89/7206	0.00541946988775
ko04710	Circadian rhythm	13/1007	43/7206	0.00603876870028
ko04966	Collecting duct acid secretion	9/1007	26/7206	0.00657198780916
ko05162	Measles	7/1007	120/7206	0.00737615242082
ko00240	Pyrimidine metabolism	6/1007	110/7206	0.00775343684182
ko04750	Inflammatory mediator regulation of TRP channels	28/1007	122/7206	0.00775671469193
ko01200	Carbon metabolism	8/1007	128/7206	0.00945529385981
ko03018	RNA degradation	4/1007	84/7206	0.0106082501239
ko04110	Cell cycle	10/1007	145/7206	0.0106491888411
ko05140	Leishmaniasis	3/1007	75/7206	0.0106849918315
ko04064	NF-kappa B signaling pathway	5/1007	96/7206	0.0108125558604
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1007	100/7206	0.0129560395872
ko04745	Phototransduction - fly	11/1007	38/7206	0.0155660184888
ko05110	Vibrio cholerae infection	16/1007	63/7206	0.0157673742523
ko00620	Pyruvate metabolism	1/1007	46/7206	0.0166321147519
ko03420	Nucleotide excision repair	1/1007	46/7206	0.0166321147519
ko00515	Mannose type O-glycan biosynthesis	8/1007	25/7206	0.0169665606346
ko04918	Thyroid hormone synthesis	20/1007	86/7206	0.0180601097667
ko04071	Sphingolipid signaling pathway	33/1007	162/7206	0.0216442840525
ko05231	Choline metabolism in cancer	28/1007	134/7206	0.0235668033376
ko00983	Drug metabolism - other enzymes	1/1007	42/7206	0.0240663708375
ko03022	Basal transcription factors	1/1007	44/7206	0.0256164037886
ko04217	Necroptosis	15/1007	178/7206	0.0284217977022
ko00480	Glutathione metabolism	2/1007	55/7206	0.0288421521628
ko04391	Hippo signaling pathway - fly	20/1007	90/7206	0.0310081911331
ko04270	Vascular smooth muscle contraction	31/1007	154/7206	0.0336014653462
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1007	40/7206	0.0362223757174
ko00140	Steroid hormone biosynthesis	1/1007	41/7206	0.0376717638948
ko00380	Tryptophan metabolism	2/1007	50/7206	0.039307332714
ko00310	Lysine degradation	4/1007	73/7206	0.0395483111638
ko05210	Colorectal cancer	19/1007	86/7206	0.0401149836831
ko00590	Arachidonic acid metabolism	2/1007	52/7206	0.0412027526078
ko05016	Huntington's disease	20/1007	215/7206	0.0455044446118
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1007	15/7206	0.0473403408538
ko04062	Chemokine signaling pathway	38/1007	201/7206	0.0492311095633
ko04210	Apoptosis	16/1007	180/7206	0.0493743670311