ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 55/859 152/7206 3.96024740103e-15 ko04713 Circadian entrainment 48/859 136/7206 6.89787272604e-13 ko04744 Phototransduction 21/859 36/7206 3.05851925882e-11 ko04024 cAMP signaling pathway 71/859 279/7206 1.80516688272e-10 ko04080 Neuroactive ligand-receptor interaction 95/859 423/7206 3.12165550281e-10 ko04728 Dopaminergic synapse 51/859 185/7206 4.91267484099e-09 ko04727 GABAergic synapse 36/859 110/7206 5.79349047515e-09 ko05032 Morphine addiction 35/859 110/7206 2.14862131313e-08 ko05033 Nicotine addiction 23/859 56/7206 2.81875501883e-08 ko04911 Insulin secretion 35/859 117/7206 1.22281036828e-07 ko05322 Systemic lupus erythematosus 1/859 151/7206 1.52387356173e-07 ko04921 Oxytocin signaling pathway 52/859 209/7206 1.77141241073e-07 ko04721 Synaptic vesicle cycle 27/859 80/7206 2.31799934527e-07 ko04020 Calcium signaling pathway 60/859 265/7206 5.50334480562e-07 ko04070 Phosphatidylinositol signaling system 32/859 112/7206 1.91714214742e-06 ko03010 Ribosome 1/859 129/7206 2.86193718049e-06 ko04725 Cholinergic synapse 40/859 160/7206 3.19754561377e-06 ko03040 Spliceosome 2/859 145/7206 3.32535609962e-06 ko05031 Amphetamine addiction 27/859 91/7206 4.03122163676e-06 ko04925 Aldosterone synthesis and secretion 30/859 105/7206 4.29383778315e-06 ko04022 cGMP-PKG signaling pathway 49/859 216/7206 5.60196880547e-06 ko04723 Retrograde endocannabinoid signaling 42/859 175/7206 7.85558114448e-06 ko04720 Long-term potentiation 28/859 99/7206 1.06668632085e-05 ko04726 Serotonergic synapse 35/859 137/7206 1.17968181739e-05 ko03013 RNA transport 4/859 166/7206 1.4997611378e-05 ko05203 Viral carcinogenesis 12/859 277/7206 1.64766922e-05 ko04710 Circadian rhythm 16/859 43/7206 1.6830416754e-05 ko04730 Long-term depression 23/859 78/7206 2.3159098567e-05 ko04970 Salivary secretion 26/859 95/7206 3.50449733342e-05 ko04745 Phototransduction - fly 14/859 38/7206 6.44626620323e-05 ko04966 Collecting duct acid secretion 11/859 26/7206 9.16573465219e-05 ko04110 Cell cycle 4/859 145/7206 0.000132365828841 ko04261 Adrenergic signaling in cardiomyocytes 43/859 205/7206 0.0001701110095 ko04971 Gastric acid secretion 25/859 98/7206 0.000199135200075 ko04072 Phospholipase D signaling pathway 41/859 197/7206 0.000306100580634 ko04742 Taste transduction 17/859 61/7206 0.000553162812087 ko03008 Ribosome biogenesis in eukaryotes 1/859 79/7206 0.000758145158667 ko04750 Inflammatory mediator regulation of TRP channels 27/859 122/7206 0.00161695663377 ko05169 Epstein-Barr virus infection 11/859 206/7206 0.00206044640756 ko04960 Aldosterone-regulated sodium reabsorption 12/859 41/7206 0.00223808900099 ko04740 Olfactory transduction 19/859 80/7206 0.00265569166879 ko05030 Cocaine addiction 18/859 73/7206 0.00282310835187 ko04972 Pancreatic secretion 24/859 111/7206 0.00295805556247 ko04626 Plant-pathogen interaction 7/859 18/7206 0.00323788444659 ko04141 Protein processing in endoplasmic reticulum 10/859 184/7206 0.00378737649755 ko04371 Apelin signaling pathway 34/859 177/7206 0.00448450432745 ko00680 Methane metabolism 10/859 34/7206 0.00492725882277 ko04964 Proximal tubule bicarbonate reclamation 9/859 29/7206 0.00509435377949 ko04922 Glucagon signaling pathway 26/859 128/7206 0.00551327081489 ko00010 Glycolysis / Gluconeogenesis 17/859 74/7206 0.00620528615617 ko04136 Autophagy - other 9/859 31/7206 0.00824333300171 ko05110 Vibrio cholerae infection 15/859 63/7206 0.00918591850996 ko04930 Type II diabetes mellitus 13/859 54/7206 0.0103678028504 ko00562 Inositol phosphate metabolism 19/859 89/7206 0.0120751005105 ko04540 Gap junction 25/859 128/7206 0.0123411636599 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/859 59/7206 0.0130447936193 ko04711 Circadian rhythm - fly 5/859 13/7206 0.013467151508 ko01230 Biosynthesis of amino acids 18/859 85/7206 0.0166012644707 ko03050 Proteasome 1/859 54/7206 0.017934997023 ko00280 Valine, leucine and isoleucine degradation 1/859 54/7206 0.017934997023 ko00230 Purine metabolism 34/859 194/7206 0.0181714497161 ko00520 Amino sugar and nucleotide sugar metabolism 1/859 55/7206 0.0186229232657 ko04350 TGF-beta signaling pathway 5/859 103/7206 0.0211895118996 ko04010 MAPK signaling pathway 52/859 321/7206 0.0214876004224 ko05217 Basal cell carcinoma 2/859 68/7206 0.0215598188355 ko04978 Mineral absorption 10/859 40/7206 0.0226231351788 ko05230 Central carbon metabolism in cancer 17/859 81/7206 0.0228305197788 ko04014 Ras signaling pathway 46/859 279/7206 0.0231547297749 ko00120 Primary bile acid biosynthesis 6/859 20/7206 0.0250793982533 ko05168 Herpes simplex infection 12/859 182/7206 0.0267662203921 ko05166 HTLV-I infection 23/859 292/7206 0.0269196012674 ko04973 Carbohydrate digestion and absorption 10/859 42/7206 0.0277545586329 ko04514 Cell adhesion molecules (CAMs) 24/859 130/7206 0.0277568108829 ko04622 RIG-I-like receptor signaling pathway 2/859 62/7206 0.0291971458154 ko04924 Renin secretion 17/859 86/7206 0.0294580990229 ko04657 IL-17 signaling pathway 4/859 87/7206 0.0298794831818 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/859 92/7206 0.0333096148091 ko05200 Pathways in cancer 44/859 492/7206 0.0363122754481 ko04137 Mitophagy - animal 16/859 82/7206 0.0393673823336 ko04360 Axon guidance 38/859 233/7206 0.0397345169135 ko05219 Bladder cancer 1/859 48/7206 0.0397732744953 ko05231 Choline metabolism in cancer 24/859 134/7206 0.0420277951148 ko04214 Apoptosis - fly 3/859 72/7206 0.0423823748744 ko04270 Vascular smooth muscle contraction 27/859 154/7206 0.0429072347401 ko02010 ABC transporters 9/859 39/7206 0.043454946711 ko05323 Rheumatoid arthritis 17/859 89/7206 0.046325497423 ko04666 Fc gamma R-mediated phagocytosis 22/859 122/7206 0.0469090875029 ko04919 Thyroid hormone signaling pathway 25/859 143/7206 0.0491650022437