ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	42/848	56/7206	4.2539361832e-28
ko04724	Glutamatergic synapse	70/848	152/7206	1.30668125884e-26
ko04080	Neuroactive ligand-receptor interaction	122/848	423/7206	6.15679196908e-23
ko05032	Morphine addiction	53/848	110/7206	1.60277563597e-21
ko04727	GABAergic synapse	50/848	110/7206	5.51897843695e-19
ko04728	Dopaminergic synapse	67/848	185/7206	1.60698990342e-18
ko04723	Retrograde endocannabinoid signaling	61/848	175/7206	4.8956949227e-16
ko04713	Circadian entrainment	52/848	136/7206	9.25510437489e-16
ko04721	Synaptic vesicle cycle	38/848	80/7206	1.66817785983e-15
ko04744	Phototransduction	24/848	36/7206	1.14923940162e-14
ko04024	cAMP signaling pathway	79/848	279/7206	1.49691253564e-14
ko04725	Cholinergic synapse	55/848	160/7206	2.83032545245e-14
ko04726	Serotonergic synapse	44/848	137/7206	1.50233304878e-10
ko04911	Insulin secretion	38/848	117/7206	1.92175592369e-09
ko05203	Viral carcinogenesis	6/848	277/7206	3.31153929445e-09
ko05030	Cocaine addiction	28/848	73/7206	4.10085200268e-09
ko04742	Taste transduction	25/848	61/7206	5.6461906488e-09
ko04020	Calcium signaling pathway	63/848	265/7206	2.66906266961e-08
ko04261	Adrenergic signaling in cardiomyocytes	52/848	205/7206	5.59140357043e-08
ko05031	Amphetamine addiction	30/848	91/7206	6.74436492549e-08
ko04060	Cytokine-cytokine receptor interaction	4/848	191/7206	1.09210338722e-06
ko04921	Oxytocin signaling pathway	49/848	209/7206	1.7066829587e-06
ko04720	Long-term potentiation	29/848	99/7206	1.82295182621e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	24/848	74/7206	1.93736383692e-06
ko05164	Influenza A	3/848	167/7206	2.40327309166e-06
ko03040	Spliceosome	2/848	145/7206	5.2839570102e-06
ko04360	Axon guidance	51/848	233/7206	1.0297322705e-05
ko04514	Cell adhesion molecules (CAMs)	33/848	130/7206	1.28109203957e-05
ko03013	RNA transport	4/848	166/7206	1.48877117128e-05
ko04970	Salivary secretion	26/848	95/7206	2.99666664934e-05
ko04730	Long-term depression	22/848	78/7206	6.03207202433e-05
ko05322	Systemic lupus erythematosus	4/848	151/7206	9.50046253371e-05
ko05169	Epstein-Barr virus infection	8/848	206/7206	0.000101038575041
ko04010	MAPK signaling pathway	60/848	321/7206	0.000249813764473
ko05168	Herpes simplex infection	7/848	182/7206	0.000256406721213
ko04120	Ubiquitin mediated proteolysis	4/848	138/7206	0.00026864363258
ko05162	Measles	3/848	120/7206	0.000472323771919
ko04972	Pancreatic secretion	26/848	111/7206	0.000491055925066
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/848	14/7206	0.000495390309194
ko04110	Cell cycle	5/848	145/7206	0.000608985729644
ko04621	NOD-like receptor signaling pathway	6/848	157/7206	0.000649309035636
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/848	182/7206	0.000962409667266
ko04964	Proximal tubule bicarbonate reclamation	10/848	29/7206	0.00118407728543
ko04260	Cardiac muscle contraction	23/848	98/7206	0.00123261780205
ko05205	Proteoglycans in cancer	16/848	271/7206	0.00141759894287
ko04070	Phosphatidylinositol signaling system	25/848	112/7206	0.00155922572225
ko04141	Protein processing in endoplasmic reticulum	9/848	184/7206	0.00167793735024
ko04974	Protein digestion and absorption	22/848	96/7206	0.00197532562867
ko04971	Gastric acid secretion	22/848	98/7206	0.002339746498
ko04740	Olfactory transduction	19/848	80/7206	0.00240495485136
ko03018	RNA degradation	2/848	84/7206	0.0033454703714
ko04072	Phospholipase D signaling pathway	37/848	197/7206	0.00337696376035
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	18/848	79/7206	0.00457377292286
ko04924	Renin secretion	19/848	86/7206	0.00611066248622
ko04022	cGMP-PKG signaling pathway	39/848	216/7206	0.00694749325986
ko04612	Antigen processing and presentation	2/848	77/7206	0.00697239907709
ko04966	Collecting duct acid secretion	8/848	26/7206	0.007978512031
ko00330	Arginine and proline metabolism	1/848	61/7206	0.0081818058499
ko05140	Leishmaniasis	2/848	75/7206	0.0102797778967
ko05161	Hepatitis B	10/848	173/7206	0.0115792633138
ko04146	Peroxisome	3/848	89/7206	0.0116236813779
ko04976	Bile secretion	17/848	80/7206	0.0134382158778
ko04925	Aldosterone synthesis and secretion	21/848	105/7206	0.0136237155687
ko04214	Apoptosis - fly	2/848	72/7206	0.0149603219801
ko04064	NF-kappa B signaling pathway	4/848	96/7206	0.015926708689
ko00480	Glutathione metabolism	1/848	55/7206	0.0182031097305
ko05166	HTLV-I infection	22/848	292/7206	0.0202216710024
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/848	15/7206	0.0244004083767
ko05145	Toxoplasmosis	7/848	126/7206	0.0252887085571
ko05414	Dilated cardiomyopathy	21/848	112/7206	0.026247569441
ko00590	Arachidonic acid metabolism	1/848	52/7206	0.0271792434913
ko04014	Ras signaling pathway	45/848	279/7206	0.0286700328398
ko00561	Glycerolipid metabolism	2/848	63/7206	0.0293645018901
ko04350	TGF-beta signaling pathway	5/848	103/7206	0.0294000030431
ko04640	Hematopoietic cell lineage	2/848	64/7206	0.029762517359
ko05034	Alcoholism	39/848	238/7206	0.0310728935948
ko04217	Necroptosis	12/848	178/7206	0.0335959849869
ko00240	Pyrimidine metabolism	6/848	110/7206	0.0362194687616
ko05215	Prostate cancer	6/848	111/7206	0.0364287544236
ko00620	Pyruvate metabolism	1/848	46/7206	0.0377330525506
ko03420	Nucleotide excision repair	1/848	46/7206	0.0377330525506
ko00270	Cysteine and methionine metabolism	1/848	47/7206	0.0381290686942
ko04630	Jak-STAT signaling pathway	8/848	132/7206	0.0400227408233
ko04657	IL-17 signaling pathway	4/848	87/7206	0.0421600413845
ko05133	Pertussis	4/848	87/7206	0.0421600413845
ko04115	p53 signaling pathway	3/848	74/7206	0.0433264874737
ko00562	Inositol phosphate metabolism	17/848	89/7206	0.0445389817734
ko04978	Mineral absorption	9/848	40/7206	0.0459577069866
ko04144	Endocytosis	52/848	342/7206	0.0477895458795