Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG00113 | 252940 | Mucopolysaccharidosis type IIID |
| ZFLNCG11358 | 300068 | Androgen insensitivity |
| ZFLNCG08256 | 614053 | Mitochondrial complex V (ATP synthase) deficiency, nuclear type 3 |
| ZFLNCG05197 | 615160 | Mitochondrial complex III deficiency, nuclear type 5 |
| ZFLNCG05735 | 194200 | Wolff-Parkinson-White syndrome |
| ZFLNCG00153 | 207800 | Argininemia |
| ZFLNCG04920 | 170390 | Andersen syndrome |
| ZFLNCG03687 | 312863 | Combined immunodeficiency, X-linked, moderate |
| ZFLNCG04662 | 255125 | Myopathy with lactic acidosis, hereditary |
| ZFLNCG12313 | 612838 | Cardiac conduction defect, nonspecific |
| ZFLNCG05682 | 612370 | Hypogonadotropic hypogonadism 5 with or without anosmia |
| ZFLNCG08398 | 613837 | Leber congenital amaurosis 11 |
| ZFLNCG02385 | 607475 | Bothnia retinal dystrophy |
| ZFLNCG01064 | 613370 | Maturity-onset diabetes of the young, type 10 |
| ZFLNCG10158 | 610353 | Epilepsy, nocturnal frontal lobe, type 4 |
| ZFLNCG09823 | 603218 | Huntington disease-like 1 |
| ZFLNCG12302 | 610125 | Retinal dystrophy, early-onset, with or without pituitary dysfunction |
| ZFLNCG10301 | 614158 | Thromboxane synthase deficiency |
| ZFLNCG10694 | 613013 | Neuroblastoma with Hirschsprung disease |
| ZFLNCG08399 | 610427 | Cone-rod synaptic disorder, congenital nonprogressive |
| ZFLNCG13262 | 214500 | Chediak-Higashi syndrome |
| ZFLNCG10738 | 607475 | Bothnia retinal dystrophy |
| ZFLNCG03614 | 611638 | Microphthalmia with coloboma 5 |
| ZFLNCG01104 | 234200 | Neurodegeneration with brain iron accumulation 1 |
| ZFLNCG04372 | 165550 | Optic nerve hypoplasia |